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Coronary Artery/Heart Disease (see also cardiovascular disease) |
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Abdominal Pain - lactobacillus reuteri - 48095 Lactobacillus Reuteri (LRD) at a dose of 2 x 108 live bacteria taken daily away from meals in a single dose significantly lowered pain intensity. [J Paediatr Child Health, 2010 Jul 8; [Epub ahead of print]. 48095 (8/2010)] Summary Interview PubMed |
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Abruptio Placenta - hyperhomocysteinemia - 32996 Hyperhomocysteinemia has been associated with placental abruption and infarction. 32996 [Placenta, 1999;20:519-529] 1999 Summary Interview PubMed |
| Diet - Low glycemic index and load: natural diet of unprocessed foods; e.g. lean meat and fish (to raise protein and lower carbohydrate intake); whole grain type cereals and some pasta and basmati rice (as little as possible); lots of nonstarchy vegetables and fruit, and low-fat dairy foods; eliminate sweetened drinks, potatoes, white bread, baked goods and snack foods. 45462/45987 [Am J Clin Nutr, Jul 2007;86:1:107-15] 10/2007 Summary Interview PubMed |
| DHEA 25-50 mg/d in chronic opioid users may be beneficial. J Pain. Dec 2006 7 12 901-7 45738 5/2007 Interview PubMed |
| DHEAS levels in opioid users were low and frequently undetectable. 45738 [J Pain, Dec 2006;7(12):901-7] 5/2007 Interview PubMed |
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Addiction - n-acetylcysteine - 45645 N-acetylcysteine 600 mg b.i.d. - 1200 mg t.i.d. has reduced cocaine and heroin craving. Am J Psychiatry 2007 164 7 1115-7 45645 [Am j Psychiatry, 2007;164(7):1115-7] 11/2007 Summary Interview PubMed |
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Adenomatous Polyps - eicosapentaenoic acid - 47914 Eicosapentaenoic acid - one gram twice daily with meals of a 99% eicosapentaenoic acid (EPA) supplement.[Gut, 2010 March 26; [Epub ahead of print]. 47914 (6/2010)] Summary Interview PubMed |
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Adrenoleukodystrophy (ALD) - methyl vitamin B12 - 24043 Methyl vitamin B12 1500 mcg/d normalized circadian rhythms. Brain and Development 1995 17 428-431 24043 1995 Summary Interview PubMed |
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Adult Respiratory Distress Syndrome (ARDS) - ginger - 47775 Ginger extract - 120 mg in divided doses with three meals during tube feeding. [J Crit Care, 2010 Feb 9; [Epub ahead of print]. 47775 (4/2010)] Summary Interview PubMed |
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Age Related Macular Degeneration - acetyl-carnitine - 43591/43893 Acetyl-carnitine 100 mg/d. Ophthalmologica May-June 2005 219 3 154-66 43591/43893 11/2005 Summary Interview PubMed |
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Age Related Macular Degeneration - carotenoid - 45466 Carotenoid 21.8 mg/d (14.9 mg of meso-zeaxanthin, 5.5 mg of lutein and 1.4 mg of zeaxanthin) increased macular pigment optical density. Nutr Metab (Lond), 2007 4 12 45466 9/2007 Summary Interview PubMed |
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Age Related Macular Degeneration - coenzyme Q10 - 43591/43893 Coenzyme Q10 10 mg/d (along with acetyl-l-carnitine 100 mg and omega-3 fatty acid 500 mg from fish oil). Ophthalmologica May-Jun 2005 219 3 154-66 43591/43893 11/2005 Summary Interview PubMed |
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Age Related Macular Degeneration - diet - 44227/45481/45762/44790 Diet - Low glycemic index (low in refined carbohydrates), high in fruit and vegetables reduces risk; high glycemic index diet increases risk. Am J Clin Nutr, Apr 2006 83 4 880-886 44227;45481;45762/44790 7/2006 Summary Interview PubMed |
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Age Related Macular Degeneration - egg yolk - 47554 Egg yolks 2-4/d increased macular pigment optical density (MPOD). [Am J Clin Nutr, 2009; 90(5): 1272-9. 47554 (12/2009)] Summary Interview PubMed |
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Age Related Macular Degeneration - eggs - 44828 Eggs - 6 per week for 12 weeks increased zeaxanthin and macular pigment optical density (MPOD). J Nutr, 2006 136 10 2568-73 44828 5/2007 Summary Interview PubMed |
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Age Related Macular Degeneration - lutein - 26771 Lutein supplementation can increase serum levels by 15 times and in macular pigment by 40%. Lutein converts to zeaxanthin in the retina. Advances in Pharmacology 1997 38 38 537-553 26771 1997 Summary Interview PubMed |
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Age Related Macular Degeneration - omega-3 fatty acids - 43591/43893 Omega-3 fatty acids 500mg/d. (750 mg fish oil with n-3 concentration of 60%). Ophthalmologica May-Jun 2005 219 3 154-66 43591/43893 11/2005 Summary Interview PubMed |
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Aggression - tryptophan - 21426 Amino acid mixtures given to aggressive healthy subjects in the ratio of human breast milk, with or without 10.6 g of tryptophan, showed with tryptophan reduced aggressiveness; without tryptophan increased aggressiveness. Arch Gen Psych December 1994 51 1004-1005 21426 1995 Summary Interview PubMed |
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Aging - (male) propionyl-L-carnitine - 42609 Carnitine - propionyl-L-carnitine 2 g/day + acetyl-L-carnitine 2 g/day produced a significant increase in nocturnal penile tumescence (NPT), sexual function, level of the mood and resistance to muscular exercise greater than testosterone replacement. Urology 2004 63 4 641-646 42609 02/2005 Summary Interview PubMed |
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Aging - (skin) niacinamide - 43579/43537 Niacinamide 5% topical (glycerol, panthenol, vitamin E, vehicle pH 6). Dermatol Surg Jul 2005 31 7 Pt 2 860-5; discussion 865 43579 / 43537 9/2005 Summary Interview PubMed |
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Aging - amino acids - 42895/43681 Amino acids mixture 12 gm/d. (L-leucine 3.8, L-lysine 2, L-isoleucine 1.9, L-valine 1.9, L-threonine 1.1, L-cystine 0.4, L-histidine 0.4, L-phenylalanine 0.3, L-methionine 0.2, L-tyrosine 0.1, and L-tryptophan 0.1.) Gerontology Sep-Oct 2005 51 5 302-8 42895/43681 11/2005 Summary Interview PubMed |
| B vitamins - 30% of 168 women 60-70 years of age did not reach the RDA for thiamine and more than 80% failed to meet the RDA for folate equivalents. Am J Clin Nutr 2003 78 765-772 40953 2003 Summary Interview PubMed |
| B vitamins - 1/3 of 168 women 60-70 years of age had indexes of thiamine and pyridoxine, and serum cobalamin indicating insufficient status; tHcy was elevated in 17.4 % (suggesting insufficient folate, vitamin B12 and/or vitamin B6); MMA was elevated in 9.6 % of the women (inadequate vitamin B12); subjects in the lowest quartile of serum folate had a 23 % higher tHcy concentration than subjects in the highest quartile. Am J Clin Nutr 2003 78 765-772 40953 2003 Summary Interview PubMed |
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Aging - cardiovascular fitness - 33860 Cardiovascular fitness maintenance (aging male) minimum 4 x per week for 1 hour: aerobic exercise - maintain a respiratory rate of 25-30 per minute or be able to carry on a conversation. Heat rate monitoring Karvonen formulae: Age 70 = 20-21 HR per 10 seconds; age 60 = 21-22 HR per 10 seconds, age 50 = 22-24 HR per 10 seconds, age 40 = 23-25 HR per 10 seconds and age 30 = 24-26 HR per 10 seconds. Age and Ageing 1999 28 531-536 33860 2000 Summary Interview PubMed |
| Creatine 3 to 25gms/d with water or juice 1 hour before and immediately after working out (training days only). Cycle creatine supplementing 4-6 weeks on and then 4-6 weeks off. J Nutr Health Aging Mar-Apr 2007 11 2 185-8 45920 10/2007 Summary Interview PubMed |
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Aging - creatine monohydrate - 45660 Creatine monohydrate 5 gm q.i.d. in elderly benefitted verbal and visual short term memory and long term memory (with or away from meals). Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 2007 14 5 517-28 45660 1/2008 Summary Interview PubMed |
| Glutathione - higher levels are associated with longevity. Cruciferous vegetable family including cauliflower, broccoli, cabbage, kale, brussels sprouts, etc. contain glutathione; and N-acetylcysteine, pine bark extract (pycnogenol), melatonin, bilberry grape extract and turmeric enhance glutathione. J Clin Epidemiol 1994 47 9 1021-1026 21961 1996 Summary Interview PubMed |
| Homocysteine elevation - maybe 5 to 10% of elderly individuals may be deficient in vitamin B12 without neurologic damage, megaloblastic anemia or a high MCV. Am J Clin Nutr 1994 60 2-11 20547 1996 Summary Interview PubMed |
| Lifestyle Measures 1) moderate amount of exercise; 2) keeping dietary fat below 20% of the caloric intake; 3) antioxidant supplements, e.g. 400 IU of vitamin E per day, 500 mg of vitamin C 3 times a day, 25,000 IU of beta-carotene every other day, 30 mg of coenzyme Q10 per day and 100 mcg of selenium daily in yeast tablets or as the selenite. Moderation in smoking and drinking and restrict caloric intake to an acceptable level. Age 1995 18 51-62 24217 1996 Summary Interview |
| Melatonin may have antiaging properties. Aging and Clinical Experimental Research 1995 7 338-339 24221 1998 Summary Interview PubMed |
| Melatonin < 3 mg/d Endocrine Jul 2005 27 2 201-12 44135 12/2005 Summary Interview PubMed |
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Aging - methylmalonic acid - 20547 Methylmalonic acid elevation - maybe 5 to 10% of elderly individuals may be vitamin B12 deficient with neurologic damage, without megaloblastic anemia or a high MCV. Am J Clin Nutr 1994 60 2-11 20547 1996 Summary Interview PubMed |
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Aging - multivitamin/mineral - 27904 Multivitamin/mineral supplement no more than 2-3 times the RDAs. Am J Clin Nutr 1997 66 478S-84S 27904 1997 Summary Interview PubMed |
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Aging - pet therapy/ownership - 23982 Pet therapy/ownership can lower blood pressure and has showed improvement in self-care functioning, irritable behavior, and withdrawn behavior, especially in elderly patients. Am J Occupat Therapy Jan 1996 50 1 47-51 23982 1997 Summary Interview PubMed |
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Aging - selenium - 43794/44052 Selenium 100 mcg/d. Clin Chem Nov 2005 51 11 2117-23 43794/44052 3/2006 Summary Interview PubMed |
| Vitamin B12 - 69 of 266 subjects > 70 years of age had serum B12 <300 pmol/L and serum methylmalonic acid (MMA) ≥0.37 µmol/L or serum total homocysteine (tHcy) ≥15 µmol/L. 1 mg cyanocobalamin I.M. injections initially followed by 2 mg orally normalized MMA in 13 of 15 subjects. Additional folic acid 5 mg/d normalized tHcy in all but 1. J Intern Med 1999 246 317-324 33146 1999 Summary Interview PubMed |
| Vitamin D deficiency is common in the elderly. Risk factors include lack of sunlight, medications, malabsorption and surgery. Vitamin D deficiency has been associated with bone loss, increased risk of fractures, muscle weakness, pain and impairment of immunologic function. J Am Geriatric Soc 1995 43 822-828 22863 1996 Summary Interview PubMed |
| Vitamin D - 30 minutes of sunlight 2 to 3 times a week; vitamin D2 100,000 IU every 3 months or vitamin D3 800-1600 I.U./d. J Am Geriatric Soc 1995 43 822-828 22863 1996 Summary Interview PubMed |
| Zinc deficiency in the elderly can lead to reduced immune function and increased infections. Aging and Clinical and Experimental Research 1995 7 2 75-76 23041 1995 Summary Interview PubMed |
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Aging - zinc gluconate - 45884 Zinc gluconate (45 mg elemental zinc) daily in a single or divided dose away from meals reduced infections, tumor necrosis factor alpha, oxidative stress markers. Am J Clin Nutr Mar 2007 85 3 837-44 45884 8/2007 Summary Interview PubMed |
| B vitamins - B1 at 5 to 140 x RDA (median = 8 x RDA); B2 at 5 to 118 x RDA (median = 6.7 x RDA); B6 at 2 to 100 x RDA (median = 3 x RDA); B3 (niacin) at 3.5 to 20 x RDA (median = 5 x RDA), total intake (food and supplements combined) associated with improved survival. Am J Epidemiol 1996 143 12 1244-1256 25119 1996 Summary Interview PubMed |
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AIDS/HIV - beta-carotene - 25243 Beta-carotene 60 mg/d (mild increase in GPX activity). Am J Clin Nutr 1996 64 101-107 25243 1996 Summary Interview PubMed |
| Curcumin 1-2 tablets initially tapering up to two 500 mg tablets t.i.d. with meals. J National Med Assoc June 1996 88 6 333 25538 1996 Summary Interview PubMed |
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AIDS/HIV - fish oil - 24119/24112 Fish oil - Five food bars per day containing 2 gm fish oil per bar. J Parent Ent Nutr 1996 20 1 43-49 24119/24112 1996 Summary Interview PubMed |
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AIDS/HIV - multivitamin/mineral - 25119 Multivitamin/mineral (high potency) with B vitamins 3-5 times the RDA. Am J Epidemiol 1996 143 12 1244-1256 25119 1996 Summary Interview PubMed |
| Myopathy (skeletal) induced by nucleoside reverse transcriptase inhibitor (NRTI) therapy - coenzyme Q10 300 mg/d reversed myopathy with concurrent zidovudine use. Int J STD AIDS 2005 16 12 827-9 43916 3/2006 Summary Interview PubMed |
| Selenium (yeast bound) 200-300 IU/d (under medical supervision 800 mcg/d). Chemico-Biological Interactions 1994 91 188-205 20378 1996 Summary Interview PubMed |
| Selenium (selenomethionine) 100 mcg/d (increase in GPX activity; decrease in beta-2 microglobulin). Am J Clin Nutr 1996 64 101-107 25243 1996 Summary Interview PubMed |
| Selenium (sodium selenite) 200-400 mcg/d (increase in GPX activity). Bio Trace Element Res 1997 56 31-41 27325 1997 Summary Interview PubMed |
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AIDS/HIV - vitamin b12 - 27086 Vitamin B12 - low serum levels were associated with progression to AIDs. J Nutr 1997 127 345-351 27086 1997 Summary Interview PubMed |
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Akathisia (Neuroleptic-Induced) - vitamin B6 - 42386 Vitamin B6 600 mg b.i.d.. [J Clin Psychiatry, November 2004, 65;11:1550-1554 42386 (01/2005)] Summary Interview PubMed |
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Alcoholism - nicotinamide - 28598/28599 Nicotinamide 1.25 gm with meals and wine intake reduced the effect of alcohol on lactate/pyruvate ratio, prevented the reduction of albumin and fibrinogen secretory rates therefore counteracting the acute hepatotoxic effect of ethanol by ameliorating the redox state. J Nutr 1997 127 2199-2204 28598/28599 1998 Summary Interview PubMed |
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Allergic Rhinitus - trans fats - 32340 Trans fats increase risk. The Lancet June 12 1999 353 2040-2041 32340 1999 Summary Interview PubMed |
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Allergy (atopic) - lactobacillus - 26730 Allergy (atopic) Lactobacillus GG 5 x 108 CFU/d in infants. J Allergy Clin Immunol 1997 99 179-185 26730 1997 Summary Interview PubMed |
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Allergy (atopic) - omega-3 fatty acids - 32892 Omega-3 fatty acids (eicosapentaenoic acid (20:5 ω-3), docosahexaenoic acid (22:6 ω-3) ) reduce atopic sensitization while omega-6 fatty acid excess (arachidonic acid (AA; 20:4 ω-6)) increase inflammatory mediators and increase atopic expression; approximate 1:1 omega-3/omega-6 ratio is optimal. Ann Med 1999 31 282-287 32892 1999 Summary Interview PubMed |
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Allergy (atopic) - trans fats - 32340 Trans fats increase risk. [The Lancet, June 12, 1999;353:2040-2041 32340 (1999)] Summary Interview PubMed |
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Allergy (childhood) - common cold - 28908 Common cold symptoms - possibly mold allergy; reduce allergy symptoms by reducing humidity in house; clean house regularly; look for stains or wet surfaces; teach children not to eat in the bedroom, not to leave the TV in the bedroom, and not to lie on carpet; clean the carpet regularly; maintain good circulation of the air throughout the house; and open the windows when weather permits. [Clinical Pediatrics, December, 1997;695-699 28908 (1998)] Summary Interview PubMed |
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Allergy (childhood) - constipation/cow’s milk - 21598 Constipation (allergic) due to T-cell reaction to cow’s milk protein. Total elimination diet trial. J Pediatr January 1995 126 34-39 21598 1995 Summary Interview PubMed |
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Allergy (childhood) - constipation/cow’s milk - 38427 / 37932 / 38145 Constipation (allergic) due to T-cell reaction to cow’s milk protein. Total elimination diet trial. Clin Pediatr July 2001 399-402 38427;37932/ 38145 2002 Summary Interview PubMed |
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Allergy (childhood) - diet - 45039 Diet - A high intake of margarine and vegetable oils during pregnancy increases the risk for eczema in the offspring, while high fish intake decreases the risk. Infants born to mothers who ate a lot of celery, citrus fruit, raw sweet pepper and deep-frying vegetable fat during pregnancy were at increased risk for allergic sensitization. [Am J Clin Nutr, 2007;85(2)530-7 (45039) 5/2007 Summary Interview PubMed |
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Allergy (childhood) - infection - 33409 Infection - early is protective. Clin Exp All 1999 29 1304-1308 33409 1999 Summary Interview PubMed |
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Allergy (childhood) - lactobacillus reuteri - 45163 Lactobacillus reuteri ATCC 55730 (LRA) 1 x 108 bacteria/d in a single daily dose orally [to mothers from 36 weeks gestation to delivery and the child from birth through 12 months] reduced IgE sensitization (and IgE eczema) (in oil drops in infants). J Allergy Clin Immunol March 7 2007 [Epub ahead of print] 45163 8/2007 Summary Interview PubMed |
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Allergy (childhood) - omega-3/omega-6 - 45163 Omega-3/omega-6 balance reduces risk. Clin Exp Allergy 1999 29 1304-1308 c 1999 Summary Interview PubMed |
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Allergy (childhood) - siblings - 33409 Siblings increase early infections which may be protective. Clin Exp All 1999 29 1304-1308 33409 1999 Summary Interview PubMed |
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Allergy (food) - prevention - 33918 Prevention - 1) Rotate the foods in your diet; 2) Avoid or reduce the intake of processed foods, especially foods high in sugar; 3) Make as much of your diet organic as possible; 4) Do not drink alcoholic beverages before eating; 5) Eat a balanced diet including grains, fresh fruit and vegetables, fresh meats, etc; 6) Chew your food well; and 7) Do not drink water during a meal. It dilutes your digestive juices. "Immunology of Food Allergy," Marinkovich, Vincent A, Personal Monograph 1999 1-7 33918 2000 Summary Interview |
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Allergy (food) - constipation - 21598 Constipation in children (cow’s milk protein, eggs, tomatoes, fish and citrus fruit, etc.). J Pediatr January 1995 126 34-39 21598 1995 Summary Interview PubMed |
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Allergy (food) - constipation - 38427 / 37932 / 38145 Allergy (food) Constipation in children (cow’s milk protein, eggs, tomatoes, fish and citrus fruit, etc.). Clin Pediatr July 2001 399-402 38427 / 37932 / 38145 2002 Summary Interview PubMed |
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Allergy (food) - Igg mast testing - 33918 IgG MAST testing - food and mold plate has foods and molds attached covalently to cellulose threads and are contained in a single pipette chamber. "Immunology of Food Allergy," Marinkovich, Vincent A, Personal Monograph, 1999 1-7 33918 2000 Summary Interview |
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Allergy (food) - prevention, treatment - 24067 Prevention and Treatment - Alka Seltzer (gold) can prevent food reactions if taken before the intake of food - works about 2/3 of time, or, when reacting to food take Alka Seltzer (gold) which relieves symptoms in about 20 minutes. J Learning Disabilities 1979 12 42-50 24067 1996 Summary Interview PubMed |
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Allergy (food) - prevention, treatment - 24068 Prevention and Treatment - Alka Seltzer (gold) can prevent food reactions if taken before the intake of food - works about 2/3 of time, or, when reacting to food take Alka Seltzer (gold) which relieves symptoms in about 20 minutes. J Learning Disabilities 1978 11 56-64 24068 1996 Summary Interview PubMed |
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Allergy (general) - herbal medications - 32662 Herbal medications (ex. Echinacea). J Asthma 1999 36 1 1-65 32662 1999 Summary Interview PubMed |
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Allergy (general) - lactobacillus reuteri - 32662 Lactobacillus reuteri ATCC 55730 (LRA) 1 x 108 bacteria/d in a single dose reduced IgE sensitization/IgE eczema (in oil drops in infants). J Allergy Clin Immunol March 7 2007 [Epub ahead of print] c 8/2007 Summary Interview PubMed |
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Allergy (general) - vitamin e - 36406 Vitamin E in diet 9 mg/d may prevent/reduce IgE allergy. The Lancet Nov. 4 2000 356 1573-1574 36406 2001 Summary Interview PubMed |
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Allergy (mold) - common cold - 28908 Common cold symptoms - possibly mold allergy; reduce allergy symptoms by reducing humidity in house; clean house regularly; look for stains or wet surfaces; teach children not to eat in the bedroom, not to leave the TV in the bedroom, and not to lie on carpet; clean the carpet regularly; maintain good circulation of the air throughout the house; and open the windows when weather permits. Clinical Pediatrics December 1997 695-699 28908 1998 Summary Interview PubMed |
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Allergy (wheat) - diet - 43145 / 45167 Diet - delaying introduction of wheat, barley, rye and oats until after 6 months of age was associated with an increased risk of wheat allergy. JAMA May 18 2005 293 19 2343-51 43145/45167 2/2007 Summary Interview PubMed |
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Alzheimers Disease - curcumin - 47274 Curcumin BCM-95 1 - 4 gm/d with food. [Journal of Clinical Psychopharmacology, 2008;28:110-13. 47274 (7/2009)] Summary Interview PubMed |
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Alzheimer’s Disease - diet - 34806 Diet after age 60 predominant risk factor. J Alzheimer’s Dis 1999 1 197-201 34806 1999 Summary Interview PubMed |
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Alzheimer’s Disease - diet - 34806 Diet low in fat and total energy, increased in fruits, vegetables and whole grains reduces the risk of Alzheimer’s disease. J Alzheimer’s Dis 1999 1 197-201 34806 1999 Summary Interview PubMed |
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Alzheimer’s Disease - diet - 42067 Diet high in total carbohydrate (refined or unrefined) with APOE4 allele (inhibit lipid metabolism similar to a high carbohydrate diet) increases risk. Medical Hypothesis 2004 62 689-700 42067 11/2004 Summary Interview PubMed |
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Alzheimer’s Disease - fat - 34806 Fat - high in total fat, saturated fat and cholesterol increase risk. [J Alzheimer’s Dis, 1999;1:197-201. 34806 1999)] J Alzheimer’s Dis 1999 1 197-201 34806 1999 Summary Interview PubMed |
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Alzheimer’s Disease - faty acids - 42067 Fatty acids - increase the omega 3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Medical Hypothesis 2004 62 689-700 42067 11/2004 Summary Interview PubMed |
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Alzheimer’s Disease - fish - 34806 Fish consumption reduced risk. J Alzheimer’s Dis 1999 1 197-201 34806 1999 Summary Interview PubMed |
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Alzheimer’s Disease - folic acid (serum) - 37878 Folic acid (serum) less than 13 nmol/L and vitamin B12 (serum) less than 251 pmol/L increases risk. [Neurology 2001;56:1188-1194 37878 2001] Summary Interview PubMed |
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Alzheimer’s Disease - genetics - apoe4 allele - 34806 Genetics - APOE4 allele is associated with an increased risk; only 10 % of Alzheimer’s disease is related to genetics. [J Alzheimer’s Dis, 1999;1:197-201 34806 1999] Summary Interview PubMed |
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Alzheimer’s Disease - ginkgo biloba - 24968 Ginkgo biloba special extract Egb 761® 240 mg/d. Pharmacopsychiat 1996 29 47-56 24968 1996 Summary Interview PubMed |
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Alzheimer’s Disease - ginkgo biloba - 46792 Ginkgo biloba special extract Egb 761® 240 mg/d. Alzheimer's and Dementia July 2008 4 4 Supplement, T165-T166 46792 11/2008 Summary |
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Alzheimer’s Disease - homocysteine - 39403 Homocysteine (a functional test for vitamin B12) is inversely related to Alzheimer’s disease/cognitive decline. Folic acid 1 mg/d, vitamin B12 500 mcg/d, vitamin B6 40 mg/d may lower homocysteine levels. Neurology 2002 58 1395-1399 39403 2002 Summary Interview PubMed |
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Alzheimer’s Disease - melatonin - 34948 Melatonin reduces formation of beta-amyloid. J Applied Nutr 1999 51 1 3-15 34948 2000 Summary Interview |
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Alzheimer’s Disease - melatonin - 45955 Melatonin 3-6 mg (fast-release) at bedtime may improve cognitive function. J Pineal Res 2007 43 4 404-409 45955 3/2008 Summary Interview PubMed |
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Alzheimer’s Disease - mitochondrial energy - 34948 Mitochondrial energy production deficit (acetyl-l-carnitine, CoQ10, phosphatidylserine, magnesium enhance mitochondrial ATP production). J Applied Nutr 1999 51 1 3-15 34948 2000 Summary Interview |
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Alzheimer’s Disease - nadh - 24840 NADH 2 - 5 mg tablets/d. Annals of Clinical and Laboratory Science 1996 26 1 1-9 24840 1996 Summary Interview PubMed |
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Alzheimer’s Disease - nadh - 34948 NADH 2 - 5 mg tablets/d. J Applied Nutr 1999 51 1 3-15 34948 2000 Summary Interview |
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Alzheimer’s Disease - nutraceutical combination Nutraceutical Combination - Folic acid 400 mcg/d, vitamin E 30 IU/d, vitamin B12 6 mcg/d, S-adenosyl methionine 400mg/d, N-acetylcysteine 600mg/d and acetyl-L-carnitine 500 mg/d in 2 pills per day taken at any time improved cognition and mood. [J Alzheimer's Dis Other Demen, Feb-Mar 2009;24(1):27-33. Epub 2008 Dec 3 ] Summary Interview PubMed |
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Alzheimer’s Disease - nutraceutical combination - 46908 Nutraceutical Combination - Folic acid 400 mcg/d, vitamin E 30 IU/d, vitamin B12 6 mcg/d, S-adenosyl methionine 400mg/d, N-acetylcysteine 600mg/d and acetyl-L-carnitine 500 mg/d in 2 pills per day taken at any time improved cognition and mood. [ Am J Alzheimer's Dis Other Demen, Dec 2008 – Jan 2009;23(6):571-85. Epub 2008 Dec 1]. 46908 (2/2009)] Summary Interview PubMed |
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Alzheimer’s Disease - pesticide exposure - 34948 Pesticide exposure. J Applied Nutr 1999 51 1 3-15 34948 2000 Summary Interview |
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Alzheimer’s Disease - vitamin b1 - 23739 Vitamin B1 (thiamine) plasma levels significantly lower; antecdotal improvement vitamin B1 3-5 gm/d. Archives of Neurology November 1995 52 1081-1085 23739 1996 Summary Interview PubMed |
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Alzheimer’s Disease - vitamin b12 - 28725 Vitamin B12 normal ranges should be 600 to 2000 pg/ml. Below 550 to 600 pg/ml deficiencies start to appear in the CSF. Humans are born with serum levels of about 2000 pg/ml, which decline gradually throughout life. Medical Hypotheses 1991 34 131-140 28725 1998 Summary Interview PubMed |
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Alzheimer’s Disease - vitamin b12 - 37878 Vitamin B12 (serum) less than 251 pmol/L and folic acid (serum) less than 13 nmol/L increases risk. Neurology 2001 56 1188-1194 37878 2001 Summary Interview PubMed |
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Alzheimer’s Disease - vitamin b12 - 39403 Vitamin B12 functional deficiency occurs from Alzheimer’s disease-related oxidative stress. Neurology 2002 58 1395-1399 39403 2002 Summary Interview PubMed |
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Alzheimer’s Disease - vitamin B12 - 46641 Vitamin B12 - low levels associated with reduced brain volume. B12 levels >300 pmol/L (406.5 pg/ml) may be protective. Neurology 2008 71 11 826-32 46641 10/2008 Summary Interview PubMed |
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