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Expert Pearls

Fatigue - alpha lipoic acid, ATP Fuel, carnitine, coq10, mitochondria, nadh - 50467

Chronic diseases of all types, including aging, result in some type of mitochondrial dysfunction. Key mitochondrial supportive nutrients (ATP Fuel®) and therapeutic dose ranges include: L-Carnitine varying from 140 mg to over 2 g per day with most recommendations in the range of 1-2 g per day in divided doses. Up to 6 g per day of dietary supplementation of L-carnitine is safe; CoQ10 has been used in doses up to 1.2 g per day. Frequent daily doses are 30-300 mg per day; Alpha lipoic acid at 200 to 600 mg per day; Microcarrier-stabilized NADH varies from 10-30 mg per day; and Lipid Replacement Therapy (NTFactor®) at 1-2 g of stabilized phospholipids. [Altern Ther Health Med. 2014 Winter; 20 (Suppl 1):18-25. 50467 (9/2014)] Interview PubMed

Fatigue - Caffeine withdrawal

Caffeine withdrawal symptoms in a.m.. [The Lancet, 1997;349:279-281. 27049 (1997)] Summary Interview

Fatigue - Diet

Diet - eliminate caffeine, sucrose and eat a higher protein and lower carbohydrate diet x 2 weeks. [The Nutrition Report, March 1991;9(3):17,24. 12081 (1996)] Summary Interview

Fatigue - inflammatory bowel disease, vitamin b1 - 50512

Vitamin B1 (thiamine) between 600 mg/day (60 kg = 132 lbs) to 1,500 mg/day (90 kg = 198 lbs) taken orally in patients with Crohn’s Disease or Ulcerative Colitis with normal blood levels of thiamine and thiamine pyrophosphate showed regression of fatigue. Too much thiamine can cause a reversible tachycardia and sleep disturbance. [Altern Complement Med. 2013 Aug;19(8):704-8. 50512 (11/2014)] Interview PubMed

Fatigue - Vitamin B12

Vitamin B12 normal ranges should be 600 to 2000 pg/ml. Below 550 to 600 pg/ml deficiencies start to appear in the CSF. Humans are born with serum levels of about 2000 pg/ml, which decline gradually throughout life. [Medical Hypotheses, 1991;34:131-140. 28725 (1998)] Summary Interview

Fatigue - vitamin c, intravenous - 49041

Vitamin C as ascorbic acid alone at 10 grams given over 30 minutes in 100 cc of normal saline improved fatigue in fatigued office workers without side effects. Fatigue symptoms improved within 2 hours and lasted for a day. Vitamin C reduced oxidative stress and increased blood levels of vitamin C. No other nutrients were give with the vitamin C. [ Nutr J. 2012 Jan 20; 11(1):7. 49041 (3/2012)] Summary Interview PubMed
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