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Expert Pearls

Aging - (male) propionyl-L-carnitine - 42609

Carnitine - propionyl-L-carnitine 2 g/day + acetyl-L-carnitine 2 g/day produced a significant increase in nocturnal penile tumescence (NPT), sexual function, level of the mood and resistance to muscular exercise greater than testosterone replacement. Urology 2004 63 4 641-646 42609 02/2005 Summary Interview PubMed

Aging - (skin) niacinamide - 43579/43537

Niacinamide 5% topical (glycerol, panthenol, vitamin E, vehicle pH 6). Dermatol Surg Jul 2005 31 7 Pt 2 860-5; discussion 865 43579 / 43537 9/2005 Summary Interview PubMed

Aging - amino acids - 42895/43681

Amino acids mixture 12 gm/d. (L-leucine 3.8, L-lysine 2, L-isoleucine 1.9, L-valine 1.9, L-threonine 1.1, L-cystine 0.4, L-histidine 0.4, L-phenylalanine 0.3, L-methionine 0.2, L-tyrosine 0.1, and L-tryptophan 0.1.) Gerontology Sep-Oct 2005 51 5 302-8 42895/43681 11/2005 Summary Interview PubMed

Aging - b vitamins - 40953

B vitamins - 30% of 168 women 60-70 years of age did not reach the RDA for thiamine and more than 80% failed to meet the RDA for folate equivalents. Am J Clin Nutr 2003 78 765-772 40953 2003 Summary Interview PubMed

Aging - b vitamins - 40953

B vitamins - 1/3 of 168 women 60-70 years of age had indexes of thiamine and pyridoxine, and serum cobalamin indicating insufficient status; tHcy was elevated in 17.4 % (suggesting insufficient folate, vitamin B12 and/or vitamin B6); MMA was elevated in 9.6 % of the women (inadequate vitamin B12); subjects in the lowest quartile of serum folate had a 23 % higher tHcy concentration than subjects in the highest quartile. Am J Clin Nutr 2003 78 765-772 40953 2003 Summary Interview PubMed

Aging - cardiovascular diseaes, macular degeneration, zinc - 50683

Zinc at 45 mg of elemental zinc daily as acetate or gluconate administered in the post absorptive state (2-3 h after dinner) has been shown to reduce cardiovascular risk. Zinc has been shown to be deficient in 30% of some elderly populations and has shown therapeutic value in slowing age-related macular degeneration, cardiovascular risk markers and infections. Doses of elemental zinc of 50 mg or more should be taken with 1 mg of copper. Serum levels of zinc are the most clinically efficient way to assess for zinc status. [J Trace Elem Med Biol. 2014 Oct;28(4):364-371. 50683 (2/2015)] Interview PubMed

Aging - cardiovascular fitness - 33860

Cardiovascular fitness maintenance (aging male) minimum 4 x per week for 1 hour: aerobic exercise - maintain a respiratory rate of 25-30 per minute or be able to carry on a conversation. Heat rate monitoring Karvonen formulae: Age 70 = 20-21 HR per 10 seconds; age 60 = 21-22 HR per 10 seconds, age 50 = 22-24 HR per 10 seconds, age 40 = 23-25 HR per 10 seconds and age 30 = 24-26 HR per 10 seconds. Age and Ageing 1999 28 531-536 33860 2000 Summary Interview PubMed

Aging - creatine - 45920

Creatine 3 to 25gms/d with water or juice 1 hour before and immediately after working out (training days only). Cycle creatine supplementing 4-6 weeks on and then 4-6 weeks off. J Nutr Health Aging Mar-Apr 2007 11 2 185-8 45920 10/2007 Summary Interview PubMed

Aging - creatine monohydrate - 45660

Creatine monohydrate 5 gm q.i.d. in elderly benefitted verbal and visual short term memory and long term memory (with or away from meals). Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 2007 14 5 517-28 45660 1/2008 Summary Interview PubMed

Aging - glutathione - 21961

Glutathione - higher levels are associated with longevity. Cruciferous vegetable family including cauliflower, broccoli, cabbage, kale, brussels sprouts, etc. contain glutathione; and N-acetylcysteine, pine bark extract (pycnogenol), melatonin, bilberry grape extract and turmeric enhance glutathione. J Clin Epidemiol 1994 47 9 1021-1026 21961 1996 Summary Interview PubMed

Aging - green tea - 50050

Green tea consumption in ascending order of intake 1 to 5 or more cups per day is associated with a reduction in functional disability (cognitive function, depression, psychological distress, stroke) and healthy life expectancy, in a dose dependent fashion. [Am J Clin Nutr. 2012 March;95(3):732-739. 50050 (5/2012)] Interview PubMed

Aging - homocysteine - 20547

Homocysteine elevation - maybe 5 to 10% of elderly individuals may be deficient in vitamin B12 without neurologic damage, megaloblastic anemia or a high MCV. Am J Clin Nutr 1994 60 2-11 20547 1996 Summary Interview PubMed

Aging - lifestyle - 24217

Lifestyle Measures 1) moderate amount of exercise; 2) keeping dietary fat below 20% of the caloric intake; 3) antioxidant supplements, e.g. 400 IU of vitamin E per day, 500 mg of vitamin C 3 times a day, 25,000 IU of beta-carotene every other day, 30 mg of coenzyme Q10 per day and 100 mcg of selenium daily in yeast tablets or as the selenite. Moderation in smoking and drinking and restrict caloric intake to an acceptable level. Age 1995 18 51-62 24217 1996 Summary Interview

Aging - melatonin - 24221

Melatonin may have antiaging properties. Aging and Clinical Experimental Research 1995 7 338-339 24221 1998 Summary Interview PubMed

Aging - melatonin - 44135

Melatonin < 3 mg/d Endocrine Jul 2005 27 2 201-12 44135 12/2005 Summary Interview PubMed

Aging - methylmalonic acid - 20547

Methylmalonic acid elevation - maybe 5 to 10% of elderly individuals may be vitamin B12 deficient with neurologic damage, without megaloblastic anemia or a high MCV. Am J Clin Nutr 1994 60 2-11 20547 1996 Summary Interview PubMed

Aging - multivitamin/mineral - 27904

Multivitamin/mineral supplement no more than 2-3 times the RDAs. Am J Clin Nutr 1997 66 478S-84S 27904 1997 Summary Interview PubMed

Aging - pet therapy/ownership - 23982

Pet therapy/ownership can lower blood pressure and has showed improvement in self-care functioning, irritable behavior, and withdrawn behavior, especially in elderly patients. Am J Occupat Therapy Jan 1996 50 1 47-51 23982 1997 Summary Interview PubMed

Aging - selenium - 43794/44052

Selenium 100 mcg/d. Clin Chem Nov 2005 51 11 2117-23 43794/44052 3/2006 Summary Interview PubMed

Aging - vitamin b12 - 33146

Vitamin B12 - 69 of 266 subjects > 70 years of age had serum B12 <300 pmol/L and serum methylmalonic acid (MMA) ≥0.37 µmol/L or serum total homocysteine (tHcy) ≥15 µmol/L. 1 mg cyanocobalamin I.M. injections initially followed by 2 mg orally normalized MMA in 13 of 15 subjects. Additional folic acid 5 mg/d normalized tHcy in all but 1. J Intern Med 1999 246 317-324 33146 1999 Summary Interview PubMed

Aging - vitamin d - 22863

Vitamin D - 30 minutes of sunlight 2 to 3 times a week; vitamin D2 100,000 IU every 3 months or vitamin D3 800-1600 I.U./d. J Am Geriatric Soc 1995 43 822-828 22863 1996 Summary Interview PubMed

Aging - vitamin d - 22863

Vitamin D deficiency is common in the elderly. Risk factors include lack of sunlight, medications, malabsorption and surgery. Vitamin D deficiency has been associated with bone loss, increased risk of fractures, muscle weakness, pain and impairment of immunologic function. J Am Geriatric Soc 1995 43 822-828 22863 1996 Summary Interview PubMed

Aging - zinc - 23041

Zinc deficiency in the elderly can lead to reduced immune function and increased infections. Aging and Clinical and Experimental Research 1995 7 2 75-76 23041 1995 Summary Interview PubMed

Aging - zinc gluconate - 45884

Zinc gluconate (45 mg elemental zinc) daily in a single or divided dose away from meals reduced infections, tumor necrosis factor alpha, oxidative stress markers. Am J Clin Nutr Mar 2007 85 3 837-44 45884 8/2007 Summary Interview PubMed
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