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Expert Pearls

HDL Cholesterol (elevating) - alpha lipoic acid - 47306

Alpha lipoic acid 400 mg/d. [Aging Clinical and Experimental Research, 2009;21(2):198. 47306 (10/2009)] Summary Interview PubMed

HDL Cholesterol (elevating) - amla - 46846

Amla (Emblica Officinalis Extract, Amlamax) at 500-1000 mg/d at bedtime with food. [Indian J Clin Biochem, 2008; 23(4): 378-381. 46846 (2/2009)] Summary Interview

HDL Cholesterol (elevating) - anthocyanins - 47395

Anthocyanins 160 mg b.i.d. [Am J Clin Nutr, 2009;90(3):485-92. 47395 (11/2009)] Summary Interview PubMed

HDL Cholesterol (elevating) - apoa5 - diet - fat - gene - 50143

Diet – high fat diet (40%) may be more effective in raising HDL cholesterol in those with the gene polymorphism APOA5 rs964184 with the G allele than those who don’t. [Am J Clin Nutr, 2012 Oct; 96(4):917-22. Epub 2012 Aug 22. 50143 (11/2012)] Interview PubMed

HDL Cholesterol (elevating) - berries - 46352

Berries 1 cup/d (black currants, bilberries, lingonberries and chokeberries, a small amounts of strawberries and raspberries). [Am J Clin Nutr, 2008 Feb;87(2):323-31. 46352 (3/2008)] Summary Interview

HDL Cholesterol (elevating) - combination therapy - 46916

Combination Therapy - Niaspan® 500-1500 mg/d at dinner-time; EPA + DHA mean dose of 1440 mg/d in a divided dose with breakfast and dinner; vitamin D 3590 IU/d (25-hydroxy vitamin D of 50-60 nag/ml) in gel cap form; and the American Heart Association Step II diet with 30% of calories from fat, ≤7% from saturated fat either stopped or reversed calcium scores. The goal was to get LDL < 60, HDL > 60 and triglycerides < 60 with the above approach. There was marked improvement in this program with the addition of vitamin D. [Am J Ther, 2008 Dec 15; [Epub ahead of print]. 46916 (3/2009)] Summary Interview PubMed

HDL Cholesterol (elevating) - egg yolks - 47554

Egg yolks 2-4/d increased HDL. [Am J Clin Nutr, 2009; 90(5): 1272-9. 47554 (12/2009)] Summary Interview PubMed

HDL Cholesterol (elevating) - garlic - 45121

Garlic - one enteric-coated garlic powder tablet (equal to 400 mg garlic, 1 mg allicin) twice daily with meals. [Lipids Health Dis, 2007 Mar 1; [Epub ahead of print]. 45121 (5/2007)] Summary

HDL Cholesterol (elevating) - green tea, pomegranate, vitamin c - 47602

PomGT tablet  (pomegranate extract (500 mg), green tea extract (300 mg) and vitamin C (60 mg) per tablet) 1 capsule 2 hours after dinner. [J Endocrinol Invest, 2009 Oct 15; (DOI: 10.3275/6564 ) [Epub ahead of print] 47602 (01/2010)] Summary Interview PubMed

HDL Cholesterol (elevating) - kale juice - 46391

Kale juice -150 mL of pure kale juice given in a single dose away from meals, equivalent to 167 gm of fresh kale which is approximately 5 servings of vegetables, lowered LDL cholesterol and increased HDL cholesterol, serum selenium and glutathione peroxidase activity. [Biomed Environ Sci, 2008;21(2):91-7. 46391 (11/2008)] Summary Interview

HDL Cholesterol (elevating) - macadamia nuts - 40452

Macadamia nuts 40-90 gm/d (12-26 nuts or 40 gm = 1/3rd cup and 90 gm = 2/3rd cup). [J Nutr, 2003;133:1060-1063. 40452 (2003)] Summary Interview

HDL Cholesterol (elevating) - niacin (niaspan®) - 31515

Niacin (Niaspan®) intermediate-sustained release (eight to 12 hours) at bedtime: 375 mg in week one; 500 mg in week two; 750 mg in week three; and 1500 mg in week four. [Am J Cardiol, December 17, 1998; 82(12A): 24U-28U. 31515 (1999)] Summary Interview

HDL Cholesterol (elevating) - niacin - 40452

Niacin: Day 1 0.25 gm after lunch, 0.5 gm after dinner and 0.5 gm at night. Day 2 0.25 gm after breakfast, 0.5 gm after lunch, 0.5 gm after dinner and 1gm at night. Day 3 0.25 gm after breakfast, 0.5 gm after lunch, 1gm after dinner and 1gm at night. Day 4 1 gm q.i.d., taken immediately after meals and at bedtime. Niacin therapy: Fibrinogen is lowered by 15%; raises HDL-C by 20- 40%; HDL2-C, the large HDL particle is raised by up to 100%; a negligible effect on smaller HDL3; LDL-C is lowered by 15-30%;small, dense LDL particles are significantly lowered; triglycerides are lowered by 15-40%; and Lp(a) decreases10-40%. [J Intern Med. 2005 Aug;258(2):94-114. 43553 (01/2005)] Summary Interview

HDL Cholesterol (elevating) - pistachio nuts - 32246B/32246

Pistachio nuts (monounsaturated fatty acids (MUFA) comprise 67 percent of total fat in pistachios; high in vitamin E and fiber) substituting 20 percent of the daily caloric intake instead of high saturated fat foods reduced total cholesterol and increased HDL cholesterol. [J Am Coll Nutr, 1999;18(3):229-232. 32246B/32246 (1999)] Summary Interview

HDL Cholesterol (elevating) - red yeast rice - 47484

Red yeast rice in 300 mg capsules, 2 capsules two times daily away from meals. [Asia Pac J Clin Nutr, 2009;18(3):310-7. 47484 (12/2009)] Summary Interview PubMed

HDL Cholesterol (elevating) - royal Jelly - 23823

Royal Jelly (67% water, 12% protein, 12% carbohydrate, 5% fat, 1% minerals and about 2% other substances, i.e. vitamins, nucleic acids and other not yet analyzed chemical compounds) 50-100 mg/d orally or 10-100 mg by injection. [Experientia, 1995; 51:927-935. 23823 (1995)] Summary Interview

HDL Cholesterol (elevating) - sesame oil - 48437

Sesame oil 35 grams per day with a fatty acid breakdown of 15.23g of linoleic acid (omega-6)/35g of oil and 14.42g of oleic acid (MUFA)/35g of oil. [Clin Nutr, 2010 Dec 15; [Epub ahead of print]. 48437 (4/2011)] Summary Interview PubMed

HDL Cholesterol (elevating) - soy protein - 42786

Soy protein containing 80 mg/d isoflavones (foods containing approximately 40 mg of isoflavones include 2 cups of soy milk, 120 g of uncooked tofu, 20g of soy flour or soy protein isolate, 75 g of uncooked tempeh, half cup of uncooked green soybeans, or 20 g of roasted or mature soybeans). [Am J Clin Nutr, 2005;81;397-408. 42786 (04/2005)] Summary Interview

HDL Cholesterol (elevating) - vitamin c - 20548

Vitamin C 500 mg/d or more. [Journal of Chiropractic Medicine, 2008; 7(2): 48-58. 46339 (061108)] ltt Summary

HDL Cholesterol (elevating) - vitamin c - 20548

Vitamin C in plasma directly related to HDL cholesterol. Vitamin C from diet 150-250 mg may increase HDL levels. [Am J Clin Nutr, 1994;60:100-105. 20548 (1995)] Summary Interview

HDL Cholesterol (elevating) - vitamin e - 35165

Vitamin E 200 mg/d - 400 mg/d (D,L-α-tocopherol) reduced HDL and LDL oxidation but increased small atherogenic LDL particles. [Atherosclerosis, 2000;150:129-134. 35165 (2000)] Summary Interview
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