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Expert Pearls

Homocysteinemia/Homocystinuria/Hyperhomocysteinemia - okinawan vegetable - 50145

Vegetables - 169 grams of 371 grams of delivered fresh Okinawan vegetables (Goya (Momordica charantia), green papaya (Carica papaya), Handama (Gynura bicolor), Karashina (Brassica juncea), Njana (Crepidiastrum lanceolatium), Fuchiba (Artemisia vulgaris) and Fudanso (Beta vulgaris)) consumed daily increased circulating endothelial progenitor cells (EPC) and were inversely related to homocysteine and lipids, but positively correlated with both urinary potassium and magnesium excretion and an increase in serum folic acid. Atherosclerosis, 2009 Jun;204(2): 544-8. Epub 2008 Oct 11. 50145 (12/2012)] Interview PubMed

Homocysteinemia/Homocystinuria/Hyperhomocysteinemia - Carnitine

Carnitine (L-) I.V. at 20 mg/kg/d over 2-3 minutes after end of every hemodialysis treatment session. [Indian J Med Sci, 200; 60(4):143-53. 44507 (10/2006)] Summary Interview

Homocysteinemia/Homocystinuria/Hyperhomocysteinemia - Carnitine - 2

Carnitine (L-) 3 gm/d in hemodialysis patients. [Cardiovas Drugs Ther, 1999;13: 537-546. 35944 (1999)] Summary Interview

Homocysteinemia/Homocystinuria/Hyperhomocysteinemia - Folic acid

Folic acid 5 mg/d and vitamin B6 250 mg/d. [Eur J Clin Investig, 1995;25:176-181. 34426/22112 (1996)] Summary Interview

Homocysteinemia/Homocystinuria/Hyperhomocysteinemia - Folic acid - 2

Folic acid 2.5 mg/d, pyridoxine 25 mg/d and vitamin B12 250 mcg/d regressed plaque in hypertensives and hyperhomocysteinemics. [The Lancet, January 4, 1998;351:263-264. 29156 (1998)] Summary Interview

Homocysteinemia/Homocystinuria/Hyperhomocysteinemia - Folic acid - 3

Folic acid 400 µg/d and vitamin B12 400 mcg/d (18 percent, homocysteine fell from 8.12 µmol/l to 6.59 µmol/l). [Am J Clin Nutr, 1998;68:1104-10. 31018 (1999)] Summary Interview

Homocysteinemia/Homocystinuria/Hyperhomocysteinemia - Folic acid - 4

Folic acid .4 - 2 mg/d, vitamin B6 10 - 25 mg/d and vitamin B12 100 - 500 ug/d. [NEJ M, February 2, 1995;332(5):328-329. 21740 (1996)] Summary Interview

Homocysteinemia/Homocystinuria/Hyperhomocysteinemia - folic acid, methylcobalamin - 47962

Folic acid 15 mg orally per day and intravenous methylcobalamin 500 mcg in hemodialysis patients. [Am J Kidney Dis, 2010 Apr 27; [Epub ahead of print]. 47962 (09/2011)] Summary Interview PubMed

Homocysteinemia/Homocystinuria/Hyperhomocysteinemia - folic acid, vitamin b6, vitamin b12 - 48248

B Vitamins folic acid 0.8 mg/d, vitamin B12 0.5 mg/d and vitamin B6 20 mg/d. [PLoS One, 2010;5(9):e12244. 48248 (11/2010)] Summary Interview PubMed

Homocysteinemia/Homocystinuria/Hyperhomocysteinemia - Homocysteine levels

Homocysteine levels > 10 µmol/l - associated with cardiovascular disease, complications in pregnancy and cognitive function. [Am J Clin Nutr, 1998;68:1104-10. 31018 (1999)] Summary Interview

Homocysteinemia/Homocystinuria/Hyperhomocysteinemia - Hyperhomocysteinemia

Hyperhomocysteinemia treated with folic acid 1 mg/d, vitamin B-6 10 mg/d and vitamin B12 12 ug/d; an additional 30% non-fasting homocysteine reduction occurs in non-fasting hemodialysis patients with the addition of folic acid 15 mg/d, vitamin B-6 100 mg/d and vitamin B12 1 mg/day. [Kidney International, 1996;49:147-152. 24342 (1996)] Summary Interview

Homocysteinemia/Homocystinuria/Hyperhomocysteinemia - Hyperhomocysteinemia - 2

Hyperhomocysteinemia has been associated with placental abruption and infarction, and recurrent pregnancy loss. [Placenta 1999;20:519-529. 32996 (1999)] Summary Interview

Homocysteinemia/Homocystinuria/Hyperhomocysteinemia - Myocardial infarction, stroke, intermittent claudication /carotid artery atherosclerosis

Risk factor for myocardial infarction, stroke, intermittent claudication and preclinical carotid artery atherosclerosis. [NEJ M, February 2, 1995;332 (5):328-329. 21740 (1996)] Summary Interview

Homocysteinemia/Homocystinuria/Hyperhomocysteinemia - N-acetylcysteine

N-acetylcysteine was given IV(50 mg/kg) or possibly 1800-2000 mg/d P.O.. [Pharmacological Research, May,1999;110:727-738. 35594/35497 (2001)] Summary Interview

Homocysteinemia/Homocystinuria/Hyperhomocysteinemia - Obstetric/gynecologic disorders

Obstetric/gynecologic disorders associated with elevated homocysteine - cervical dysplasia; eclampsia/preclampsia; fetal growth retardation; neural tube defects; ovarian cancers; recurrent spontaneous abortions. [Hum Repro Update 1999;5(4):64-72. 32725 (1999)] Summary Interview
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