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Expert Pearls

Inflammation - amla - 46846

Amla (Emblica Officinalis Extract, Amlamax) at 500-1000 mg/d at bedtime with food. [Indian J Clin Biochem, 2008; 23(4): 378-381. 46846 (2/2009)] Summary Interview

Inflammation - anthocyanins - 45531

Anthocyanins 75 mg/capsules 2 B.I.D. (300 mg anthocyanins/d = 100 g of fresh bilberries). [J Nutr, 2007;137 (8):1951-4. 45531 (9/2008)] Summary Interview

Inflammation - Anxiety, melatonin, pain, sleep, surgery - 50788

Melatonin given perioperatively between 2-10 mg in a single or multiple doses throughout the day, up to possibly 300 mg/kg/bw, has analgesic, anxiolytic, anti-inflammatory and sleep normalizing effects, and an excellent safety profile, any of which may significantly improve quality of life in surgical patients. [Anaesthesia. 2014 Oct;69(10):1163-71. 50788 (5/2105)] Interview PubMed

Inflammation - blueberries, insulin resistance - 50304

Blueberries - 1 serving per day rich in anthocyanins (flavonoids) reduced inflammation and insulin resistance. [J Nutr. 2013 Dec 11. [Epub ahead of print] 50304 (2/2014)] Interview PubMed

Inflammation - C-reactive protein - 47014

Fiber (dietary) consumption between 3.3 - 7.8 g/MJ significantly lowered CRP by 25% - 54%. [Eur J Clin Nutr, 2009 Feb 18; [Epub ahead of print]. 47014 (5/2009)] Summary Interview PubMed

Inflammation - cereal fiber - 44054

Cereal fiber consumption lowered C-reactive protein, tumor necrosis factor-alpha and insulin. [Diabetes Care,2006; 29(2): 207-11. 44054 (3/2006)] Summary Interview

Inflammation - coenzyme q10, mediterranean diet - 48960

Mediterranean diet plus 200 mg of CoQ10 in a single dose with meals. [J Gerontol A Biol Sci Med Sci, 2011 Oct 20; [Epub ahead of print]. 48960 (12/2011)] Summary Interview PubMed

Inflammation - coffee - 44054

Coffee - compared to non-coffee drinkers men and women who consumed > 200 ml/d had 52% higher interleukin - 6, 34% higher C-reactive protein, 20% higher serum amyloid - A, 28% higher tumor necrosis factor-alpha and 3% higher white blood cell counts. [Am J Clin Nutr, 2004;80:862-867. 44054 (11/2004)] Summary Interview

Inflammation - conjugated linoleic acid - 47321

Conjugated linoleic acid(CLA)at 3.12 gm in 200g /week. [Nutr Metab Cardiovasc Dis, 2009 May 25; [Epub ahead of print]. 47321 (8/2009)] Summary Interview PubMed

Inflammation - dha, docosahexaenoic acid - 48916

DHA 400 mg/day (each softgel capsule containing 100 mg DHA) taken from the twelfth week of gestation and continued until the end of the fourth post-partum month in breast-feeding women improved cytotoxicity and reduced pro-inflammatory mediators in infants. [Mediators Inflamm. 2011;2011:493925 48916 (12/2011)] Summary Interview PubMed

Inflammation - dha, epa, salmon - 48957

Salmon two portions per week equaling 1.8 g of combined EPA plus DHA per portion (500 mg/d of omega-3 fatty acids. [Am J Clin Nutr, 2011, 94, 1418-1425. 48957 (12/2011)] Summary Interview PubMed

Inflammation - diet - 44550/45118

Diet - low-GI diet reduces oxidative stress. [Am J Clin Nutr, 2006 Jul;84(1):70-6. 44550/45118 (10/2006)] Summary

Inflammation - fiber - 44191/44784

Fiber - increase fiber intake 20-35 gm (inversely related to CRP levels). [Am J Clin Nutr, 2006 Apr;83(4):760-6. 44191/44784 (5/2005)] Summary Interview

Inflammation - fish oil - 47796

Fish oil given parenterally in a 50:40:10 mixture of medium-chain fatty acids, soybean oil and fish oil reduced interleukin-6 in the blood, improved lung function and shortened hospital stay. [Critical Care, Jan 19, 2010;14:R5. 47796 (5/2010)] Summary Interview PubMed

Inflammation - gamma-linolenic acid - 27951

Gamma-linolenic acid (GLA) 3 gm/d increased DGLA to a greater extent than AA in neutrophils obtained from subjects after 3 wk of supplementation and may represent a mechanism by which dietary GLA exerts an anti-inflammatory effect. [J Nutr, 1997;127:1435-1444. 27951 (1997)] Summary Interview

Inflammation - glutathione, n-acetylcysteine, oxidative stress - 51034

Glutathione (GSH – reduced) in a sublingual form 150 mg 3 times daily away from meals and N-acetylcysteine (NAC) 200 mg in a single sachet taken once per day away from meals compared to oral glutathione 150 mg 3 times daily away from meals showed an increase of total and reduced GSH levels in the sublingual GSH group and, to a lesser extent, in the NAC group; the GSH/GSSG ratios in the NAC and sublingual GSH arms were significantly higher than oral GSH, which suggests that for GSH pool replenishment oral GSH < NAC < sublingual GSH. [Redox Biol. 2015 Jul 29;6:198-205. 51034 (1/2016)] Interview PubMed

Inflammation - kale juice - 46391

Kale juice -150 mL of pure kale juice given in a single dose away from meals, equivalent to 167 gm of fresh kale which is approximately 5 servings of vegetables, lowered LDL cholesterol and increased HDL cholesterol, serum selenium and glutathione peroxidase activity. [Biomed Environ Sci, 2008;21(2):91-7. 46391 (11/2008)] Summary Interview

Inflammation - lyc-o-mato® - 44192

Lyc-O-Mato® (250 ml) providing 5.7 mg lycopene, 3.7 mg phytoene, 2.7 mg phytofluene, 1 mg beta-carotene and 1.8 mg alpha-tocopherol = 100 g of raw tomatoes or about 50 g of tomato sauce). [J Agric Food Chem, 2006;54(7):2563-6. 44192 (6/2006)] Summary Interview

Inflammation - magnesium - 48503

Magnesium citrate providing 320 mg elemental magnesium daily. Five capsules daily each providing 64 mg of magnesium. Two capsules with the morning meal, one with at the noon meal, and two during the evening meal. [Magnes Res, 2010 Dec 1; 23(4): 158-68. 48503 (3/2011)] Summary Interview PubMed

Inflammation - mediterranean diet - 43997/44405

Mediterranean diet (high consumption of fruits, vegetables, bread and other cereals, potatoes, beans, nuts and seeds. Olive oil is an important monounsaturated fat source. Dairy products, fish and poultry are consumed in low to moderate amounts, and little red meat is eaten. Eggs are consumed zero to four times a week. Wine is consumed in low to moderate amounts) reduced CRP levels. [Ann Nutr Metab, 2006;50(1):20-4. Epub 2005 Nov 4. 43997/44405 (3/2006)] Summary Interview

Inflammation - melatonin - 48703

Melatonin in 3 mg capsules taken orally, 1 capsule two days before the exercise test with the dinner, 3 capsules on the previous day (breakfast, lunch and dinner), 1capsule one hour before beginning the physical test. [J Pineal Res, 2011 April 21; [Epub ahead of print]. 48703 (6/2011)] Summary Interview PubMed

Inflammation - n-acetylcysteine - 46020

N-acetylcysteine 150 mg/kg and then 15 mg/kg/hr from a continuous I.V. infusion inhibited the adverse effects of E. coli endotoxin on renal function. [Crit Care Med, 2007; 35(8):1869-75. 46020 (7/2008)] Summary Interview

Inflammation - obesity - 45301

Central obesity causes low-grade inflammation. [Am J Clin Nutr. 2006 Sep;84 (3):505-12. 45301 (2/2007)] Summary Interview

Inflammation - omega-3 fatty acids - 49170

Omega-3 fatty acids in a single daily dose of 2.4 g of omega-3 fatty acids (1800 mg eicosapentaenoic acid + 600 mg docosahexaenoic acid) after hemodialysis treatment away from meals and 30 ml of Proteinex 18 (18 grams of protein), a hydrolyzed collagen containing essential amino acids, by mouth after each dialysis three times per week. [Vasc Health Risk Manag; 2012; 8:187-95. 49170 (5/2012)] Summary Interview PubMed

Inflammation - probiotics - 40427

Probiotics (Bifidobacterium bifidum W23, Bifidobacterium lactis W51, Enterococcus faecium W54, Lactobacillus acidophilus W22, Lactobacillus brevis W63, and Lactococcus lactis W58; Ecologic®Performance or OMNi-BiOTiC®POWER) at 2 sachets per day at 2 g each (4g/day), equivalent to1010 CFU/day was taken in 100–125 mL of plain water with one sachet taken one hour prior to meals decreased zonulin levels suggesting improvement in gut barrier integrity. [J Int Soc Sports Nutr, 2012 Sep 20;9(1):45. 49368 (11/2012)] Summary Interview PubMed

Inflammation - pycnogenol® - 44232

Pycnogenol® 200 mg/d (1 mg per lb body weight). [J Inflamm (Lond), 2006;3:1. 44232 (5/2006)] Summary Interview

Inflammation - pyridoxine-hcl - 48043

Pyridoxine-HCl tablets 100 mg daily (plus 5 mg folic acid) taken before breakfast reduced plasma IL-6 and TNF- levels (inflammatory markers). [Eur J Clin Nutr, 2010;64:1007-1013. 48043 (5/2011)] Summary Interview PubMed

Inflammation - sea buckthorn berries - 45469

Sea buckthorn berries 28 g/d (16.7 mg of flavonol glycosides = 8.4 mg of flavonol aglycones = vitamin C 15.6 mg/ 28 g and vitamin E - alpha-tocopherol 1.1 mg/ 28 g). [Eur J Clin Nutr, 2007 Jun 27; [Epub ahead of print]. 45469 (9/2007)] Summary Interview

Inflammation - spirulina - 46595

Spirulina (blue-green algae) 4g (20 tablets) at a time, twice a day (one in the morning, and another in the afternoon), regardless of food intake reduced cholesterol, IL-6 and increased IL-2. [Ann Nutr Metab, 2008;52(4):322-328. 46595 (11/2008)] Summary Interview

Inflammation - whole grain - 44054

Whole grain consumption lowered C-reactive protein, tumor necrosis factor-alpha and insulin. [Diabetes Care,2006; 29(2): 207-11. 44054 (3/2006)] Summary Interview
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