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Expert Pearls

Insulin Resistance/Hyperinsulinemia - acetyl-l-carnitine - 47473

Acetyl-L-carnitine - 1 gram B.I.D. on empty stomach before breakfast and 2 hours after dinner. [Hypertension 2009; 54(3): 462-4. 47473 (11/2009)] Summary Interview PubMed

Insulin Resistance/Hyperinsulinemia - adiposity, beta-carotene, juice plus+ - 49085

Juice Plus+® at 2 active capsules per day, which provided approximately 3.75 mg of beta-carotene, 117 mg of vitamin C, 22.5 IU of vitamin E, 210 mcg of folate, 30 mg of calcium, and 21 kJ per day, was given in capsule or powdered form with meals, with at least 5 grams of fat to obese pre-pubertal boys (6-10 years of age) and resulted in a 300% increase in beta-carotene, improved insulin sensitivity and reduced abdominal adiposity within 6 months. [J Pediatr, 2012 Feb 28; [Epub ahead of print]. 49085 (4/2012)] Summary Interview PubMed

Insulin Resistance/Hyperinsulinemia - alpha-lipoic acid - 45077

Alpha-lipoic acid 600 mg q. 12 hrs, 30 minutes before meals improved insulin sensitivity and glucose disposal rate. [Hormones (Athens), 2006; 5(4): 251-8. 45077 (6/2007)] Summary Interview

Insulin Resistance/Hyperinsulinemia - beta-glucan - 48935

Beta glucan (barley) 3g/d and 6g/d per day given as a flavored water beverage (1g or 2g dose) taken in a divided dose 3 times a day with meals. [Nutr Metab (Lond), 2011 Aug 16; 8:58. 48935 (12/2011)] Summary Interview PubMed

Insulin Resistance/Hyperinsulinemia - blueberries, inflammation - 50304

Blueberries - 1 serving per day rich in anthocyanins (flavonoids) reduced inflammation and insulin resistance.

[J Nutr. 2013 Dec 11. [Epub ahead of print] 50304 (2/2014)] Interview PubMed

Insulin Resistance/Hyperinsulinemia - caffeine - 41815

Caffeine at 5 mg/kg body weight increased insulin resistance in obese non-diabetics. [Am J Clin Nutr,2004;80:22-28. 41815 (2004)] Summary Interview

Insulin Resistance/Hyperinsulinemia - carnitine - 47974

Carnitine (L)1 gram two times daily before main meals. [JPEN J Parenter Enteral Nutr, 2010 May-June;34(3): 295-9. 47974 (7/2010)] Summary Interview PubMed

Insulin Resistance/Hyperinsulinemia - chocolate (dark) - 42904

Chocolate (dark) 100 mg/d (=500 mg polyphenols) reduced insulin resistance. [Am J Clin Nutr, 2005;81:611-614. 42904 (04/2005)] Summary Interview

Insulin Resistance/Hyperinsulinemia - chromium - 44312

Chromium - yeast bound 400 mcg/d. [Biol Trace Elem Res, 2006;109(3):215-30. 44312 (7/2006)] Summary Interview

Insulin Resistance/Hyperinsulinemia - cinnamon - 45393 / 46012

Cinnamon 6 gms/d. [Am J Clin Nutr. 2007 Jun;85(6):1552-6. 45393/46012 (10/2007)] Summary Interview

Insulin Resistance/Hyperinsulinemia - conjugated linoleic acid - 45347

Conjugated linoleic acid (CLA) 4 gm/d with meals q.i.d. DECREASED insulin sensitivity. [Appl. Physiol. Nutr. Metab. 2007;32:372-382. 45347 (08/2007)] Summary Interview

Insulin Resistance/Hyperinsulinemia - cow’s milk - 37796

Cow’s milk (fermented or non-fermented) is insulinemic and insulinotrophic but low glycemic. [Am J Clin Nutr, 2001;74:96-100. 37796 (2001)] Summary Interview

Insulin Resistance/Hyperinsulinemia - curcumin - 49352

Curcumin in a 150 mg capsule 30 minutes after breakfast and another 30 minutes after supper significantly decreased fasting blood glucose, the insulin resistance index (HOMA-IR), serum total FFAs and triglycerides while increasing LPL activity. No side effects were noted. [Nutr Food Res, 2012 Aug 29; [Epub ahead of print]. 49352 (10/2012)] Summary Interview PubMed

Insulin Resistance/Hyperinsulinemia - diet - 46077

Diet - Pritikin Program of a low-fat diet with a good omega-6:omega-3 fatty acids, high in fiber consisting of natural foods, whole grains, fruits and vegetables; 60 minutes of daily aerobic activities as well as stretching and flexibility reduces insulin levels. [Prostate Cancer Prostatic Dis, 2008 Feb 19; [Epub ahead of print]. 46077 (4/2008)] Summary Interview

Insulin Resistance/Hyperinsulinemia - docosahexaenoic acid (dha), algae schyzochitrium - 48467

Docosahexaenoic acid (DHA) from the algae Schyzochitrium at 250 mg or 500 mg per day. [Arch Dis Child, 2011, Jan 12; [Epub ahead of print]. 48467 (3/2011)] Summary Interview PubMed

Insulin Resistance/Hyperinsulinemia - lychee - oligonol® - 47559

Oligonol®, a polyphenol extracted from Lychee, given at dose of two 50 mg capsules two times per day after breakfast and dinner. Journal of Functional Foods, 2009 [published ahead of print]. 47559 (12/2009)] Summary Interview

Insulin Resistance/Hyperinsulinemia - magnesium chloride - 48475

Magnesium at 2.5 g daily of magnesium chloride (50 ml of a 5% MgCl2; equivalent of 450 mg of elemental magnesium) taken fasting once daily in a single dose. [Eur J Clin Invest, 2011, Jan 17; [Epub ahead of print]. 48475 (3/2011)] Summary Interview PubMed

Insulin Resistance/Hyperinsulinemia - magnesium-aspartate-hydrochloride - 48451

Magnesium-aspartate-hydrochloride enteric coated tablets at a total daily dose of 15 mmol (365 mg) of elemental Mg, taken in three divided doses before meals. [Diabetes Obes Metab, 2010, Nov 18; [Epub ahead of print]. 48451 (3/2011)] Summary Interview PubMed

Insulin Resistance/Hyperinsulinemia - phytoestrogens, soy protein - 48527

Soy protein concentrate 30 gms (70% proteins) containing 16 mg of phytoestrogens (54% genistein, 35% daidzein, and 12% glycitein) reduced blood pressure, HS C-reactive protein and insulin resistance and triggered overt hypothyroidism in subclinical hypothyroid patients. [ J Clin Endocrinol Metab, 2011 Feb 16; [Epub ahead of print]. 48527] Summary Interview PubMed

Insulin Resistance/Hyperinsulinemia - plant protein - 22584

Plant protein decreases insulin hypersecretion while animal protein increases insulin hypersecretion. [Nutrition Research, 1994;14(12):1853-1895. 22584 (1996)] Summary Interview

Insulin Resistance/Hyperinsulinemia - soft drinks - 33945

Soft drinks with refined sugars, especially in children at the onset of puberty and with high BMIs and leptin levels, are susceptible to hyperinsulinemia. [Eur J Cancer Prev 1999;8:289-295. 33945 (2000)] Summary Interview

Insulin Resistance/Hyperinsulinemia - transcendental meditation - 45012

Transcendental meditation (TM) 2 x per day for 20 minutes each session reduced blood pressure, blood sugar, blood insulin, insulin resistance and heart rate variability improved. [Arch Intern Med, 2006 Jun 12;166(11):1218-24. 45012 (10/2006)] Summary Interview

Insulin Resistance/Hyperinsulinemia - vanadyl sulphate - 37127

Vanadyl sulphate 150 mg/d. [J Clin Endocrinol Metab, March, 2001:86(3):1410-1417. 37127 (2001)] Summary Interview

Insulin Resistance/Hyperinsulinemia - vitamin d - 26930

Vitamin D enhances islet cell insulin secretion, reduces insulin resistance and hyperinsulinemia. [Diabetologia, 1997;40:344-347. 26930 (1997)] Summary Interview
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