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Expert Pearls

Multiple Sclerosis - coq10, ubiquinol - 49623

Coenzyme Q10 (ubiquinone) 500 mg daily, divided into 100 mg capsules given with meals (2 capsules with breakfast, 2 capsules with lunch and 1 capsule with dinner)significantly increased SOD activity and decreases in MDA levels without side effects.

[Int J Neurosci, 2013 May 10; [Epub ahead of print]. 49623 (6/2013)] Summary Interview PubMed

Multiple Sclerosis - fatigue, vitamin B1 - 50487

Vitamin B1 (thiamine) between 600 mg (60 kg/bw) and 1800 mg (80 kg/bw) per day in divided doses 2 to 3 times daily with the last intake of thiamine taken before 5:00 p.m.. Intramuscular injections with thiamine at 100 mg/ml every 7 days. [BMJ Case Rep, 2013 Jul 16;2013. 50487 (12/2014)] Interview PubMed

Multiple Sclerosis - Homocysteine

Homocysteine is elevated in the blood and CSF of MS patients. A functional B12 deficiency may be present and possible injectable I.M. vitamin B12 therapy may be warranted. [Biogenic Amines, 1995;11(6):479-485. 24073 (1997)] Summary Interview

Multiple Sclerosis - lipoic acid - 50444

Lipoic acid 600 mg twice daily (every 12 hours) 1 hour after meals improved serum antioxidant capacity and decreased inflammatory cytokines including INF-γ, ICAM-1 and MMP-9 with minimal side effects. [Neuroimmunomodulation. 2014;21(6):291-6. 50444 (9/2104)] Interview PubMed

Multiple Sclerosis - melatonin - 49562

Melatonin 10 mg at 6 p.m. daily increase antioxidant enzymes and decrease lipid peroxidation in progressive MS patients in 30 days. [J Neuroimmunol, Apr 15, 2013;257(1-2):97-101. 49562 (4/2013)] Summary Interview PubMed

Multiple Sclerosis - melatonin - 50581

Melatonin benefits immune and glial cells, inflammation, mitochondrial energy production, and gut permeability. Doses used are 2-10 milligrams for sleep induction, 10-20 milligrams in cancer treatment, and in late-stage cancer and motor neuron disease, up to 3,000 mg, which has produced no serious side-effects. [Mult Scler Relat Disord. 2015 Mar;4(2):112-23. 50581 (5/2015)] Interview PubMed

Multiple Sclerosis - omega-3 fatty acids, omega-6 fatty acids - 50561

Omega-3 and 6 fatty acids at approximately 16 grams (PLP10) or a daily dose of a 19.5 ml mixture of EPA (1650 mg)/DHA (4650 mg)/GLA (2000 mg)/LA (3850 mg)/total other Ω-3 (600 mg)/total MUFA (1714 mg) + total SFA (18:0 160 mg and 16:0 650 mg)/vitamin A (0.6 mg)/vitamin E (22 mg) plus pure γ-tocopherol (760 mg) plus citrus-aroma in a ratio of Ω-3 (DHA/EPA 3:1) and Ω-6 (LA and GLA 2:1) in 1:1 wt/wt reduced relapses and probability of disability progression. [BMJ Open. 2013 Apr 17;3(4). 50561 (9/2014)] Interview PubMed

Multiple Sclerosis - Picotesla electromagnetic therapy

Picotesla electromagnetic therapy - The amplitude or intensity of the magnetic field is extremely low. The electromagnetic field device produces an alternating current field of an amplitude of 7.5 picotesla (i.e., 7.5 x 10-12 Tesla or 0.000075 mG) which can be measured with a superconducting magnetometer. The amplitude of the signal field used in the treatment is several million fold weaker than the background signal of the earth's magnetic field. [Int J Neurosci, 1995;83:187-198. 24113 / Int J Neurosci, 1995;83:69-79. 23966 / Int J Neurosci, 1995;82:223-242. 22870 / Int J Neurosci,1996;84:157-164. 24371 (1997)]

Multiple Sclerosis - vitamin a - 50324

Vitamin A normalization by diet, possibly supplementation, along with vitamin D may help in multiple sclerosis. Retinoic acid appears to decrease inflammation and at the same time increase tolerance of autoimmunity. It may also help in brain protection. [CNS Drugs, 2014 Apr;28(4):291-9. 50324 (6/2014)] Interview PubMed

Multiple Sclerosis - Vitamin D

Vitamin D supplementers 40% lower risk. [Ann Pharmacother, 2006 May 9 [Epub ahead of print]. 44285 (6/2006)] Summary Interview

Multiple Sclerosis - Vitamin D - 2

Vitamin D 5000 IU/d from 20 gm of cod liver oil. [Ann Pharmacother, 2006 May 9 [Epub ahead of print]. 44285 (6/2006)] Summary Interview

Multiple Sclerosis - Vitamin D - 3

Vitamin D lower levels associated with multiple sclerosis. [J Am Diet Assoc, Mar 2006;106(3):418-24. 44101/44585 (5/2006)] Summary Interview

Multiple Sclerosis - vitamin d - 47965

Vitamin D at 2000 IU can reduce pediatric relapse by one half. Increasing vitamin D by 10 ng/mL correlated with a 34 percent decrease in the rate of subsequent relapses. [Ann Neurol, 2010;67(5):618-24. 47965 (09/2010)] Summary Interview PubMed
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