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Expert Pearls

Nephropathy (Contrast-Induced) - n-acetylcysteine - 50370

N-acetylcysteine may be beneficial in a wide range of conditions with oxidative stress and depleted intracellular glutathione including acetaminophen overdose, diabetic atherothrombosis, cystic fibrosis and contrast-induced nephropathy. It’s effectiveness may be dose-dependent with the degree of glutathione depletion. In acetaminophen overdose dosing has been three consecutive intravenous infusions of 150, 50, 100 mg/kg respectively each over 1 hour and oral and nebulized doses between 700-2800 mg/d. [Pharmacol Ther. 2014 Feb;141(2):150-9. 50370 (6/2014)] Interview PubMed

Neuropathy (anti-retroviral) - acetyl-l-carntine - 44095

Acetyl-l-carntine 3 gms/d. [HIV Clinical Trials, 2005; 6(6): 344-350. 44095 (4/2006)] Summary Interview PubMed

Neuropathy (diabetic) - diet - 21878

Diet - vegan diet which excludes any food or drink that comes from animal, fish, meat, milk or eggs; excludes refined foods such as free fats (oil, shortening or margarine, etc.); free carbohydrates (sugar, syrups, starch, etc.); or refined cereals (white rice, white flour, etc.); or refined legumes (soy protein isolate or soy protein concentrate products). Eat only whole nuts, beans, seeds, whole grains, fruit and vegetables. [J Nutr Med, 1994;4:431-439. 21878 (1996)] Summary Interview

Neuropathy (diabetic) - gamma-linolenic acid - 28204

Gamma-linolenic acid (GLA) 480 mg/d. [Diabetes, 1997;46(Suppl. 2):S90-S93. 28204 (1998)] Summary Interview PubMed

Neuropathy (diabetic) - vitamin b1 - 25833

Vitamin B1 (benfothiamine) 3 x 100 mg/d for 2 to 3 weeks and thereafter a dose of 1 to 2 x 100 mg/d benefitted diabetic polyneuropathy. [Exp Clin Endocrinol Metab, 1996;104:311-316. 25833 (1997)] Summary Interview PubMed

Neuropathy (idiopathic) - creatine monohydrate - 31840

Creatine monohydrate 10 gm/d for five days followed by 5 gm/d for five days. [Neurology March, 1999;52:854-855. 31840 (1999)] Summary Interview PubMed

Neuropathy (peripheral) - vitamin b12 - 28725

Vitamin B12 normal ranges should be 600 to 2000 pg/ml. Below 550 to 600 pg/ml deficiencies start to appear in the CSF. Humans are born with serum levels of about 2000 pg/ml, which decline gradually throughout life. [Medical Hypotheses, 1991;34:131-140. 28725 (1998)] Summary Interview PubMed

Neuropathy - acetyl-l-carnitine, chemotherapy-induced - 49654

Acetyl-L-carnitine (ALC) at 3,000 mg per day in 409 women with breast cancer undergoing adjuvant taxane-based chemotherapy increased chemotherapy-induced neuropathy (CIPN). [J Clin Oncol, 2013 Jun 3; [Epub ahead of print]. 49654 (7/2013)] Summary Interview PubMed

Neuropathy - cisplatin - vitamin e - 47824

Vitamin E as alpha-tocopherol at 400 mg per day in a single dose away from meals significantly protected against cisplatin peripheral neurotoxicity and reduced the incidence and intensity of neuropathic signs and symptoms. [Neurology, 2010;74(9):762-6. 47824 (5/2010)] Summary Interview PubMed
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