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Expert Pearls

Niacin Therapy - Fibrinogen

Fibrinogen is lowered by 15%; raises HDL-C by 20-40%; HDL2-C, the large HDL particle is raised by up to 100%; a negligible effect on smaller HDL3; LDL-C is lowered by 15-30%; small, dense LDL particles are significantly lowered; triglycerides are lowered by 15-40%; and Lp(a) decreases10-40%. Niacin protocol: Day 1 0.25 gm after lunch, 0.5 gm after dinner and 0.5 gm at night. Day 2 0.25 gm after breakfast, 0.5 gm after lunch, 0.5 gm after dinner and 1gm at night. Day 3 0.25 gm after breakfast, 0.5 gm after lunch, 1gm after dinner and 1gm at night. Day 4 1 gm q.i.d., taken immediately after meals and at bedtime. [J Intern Med. 2005 Aug;258(2):94-114. 43553 (01/2005)] Summary Interview
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