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Expert Pearls

Obesity - 5-hydroxy-tryptophan - 30375

5-hydroxy-tryptophan (5-HTP) 750 mg/d reduced carbohydrate intake and cravings in non-insulin dependent diabetics. [Intern J Obesity, 1998; 22:628-654. 30375 (1998)] Summary Interview PubMed

Obesity - adiposity, beta-carotene, insulin resistance, juice plus+ - 49085

Juice Plus+® at 2 active capsules per day, which provided approximately 3.75 mg of beta-carotene, 117 mg of vitamin C, 22.5 IU of vitamin E, 210 mcg of folate, 30 mg of calcium, and 21 kJ per day, was given in capsule or powdered form with meals, with at least 5 grams of fat to obese pre-pubertal boys (6-10 years of age) and resulted in a 300% increase in beta-carotene, improved insulin sensitivity and reduced abdominal adiposity within 6 months. [J Pediatr, 2012 Feb 28; [Epub ahead of print]. 49085 (4/2012)] Summary Interview PubMed

Obesity - alpha lipoic acid, endothelial dysfunction - 50564

Alpha lipoic acid (ALA) at 1800 mg per day in obese subjects with hypertension, diabetes mellitus, or hypercholesterolemia lead to modest weight loss. [Curr Med Chem. 2014 Jul 6. [Epub ahead of print] 50564 (11/2104)] Interview PubMed

Obesity - catechins - 42642

Catechins 690 mg in 1 bottle/d oolong tea (from green tea extract). [Am J Clin Nutr, 2005;81:122-129. 42642 (04/2005)] Summary Interview

Obesity - electroacupuncture - 43671 / 43781

Electroacupuncture reduced 2.3% of waist circumference and 1.7 kg weight loss after six weeks of treatment. [J Womens Health (Larchmt). 2005 Jun;14 (5):434-40. 43671/43781 (10/2005)] Summary Interview

Obesity - exercising - 33427

Exercising more than 200 minutes per week intermittently throughout the day; at one setting throughout the day; and/or providing home exercise equipment (treadmill) led to successful weight loss. [ JAMA October 27, 1999;282(16):1554-1560. 33427 (2000)] Summary Interview

Obesity - flaxseed - 47387

Flaxseed powder 30 g per day in bread helped reduce central obesity. [Am J Clin Nutr 2009;90:288-97. 47387 (7/2011)] Summary Interview PubMed

Obesity - growth hormone - 43131

Growth hormone 0.13 mg/d x 2 weeks; increased to 0.27 mg/d x 2 weeks; 0.4 mg/day after 4 weeks; 0.53 mg/day after 5 weeks; and after 6 weeks to the target dose of 0.67 mg/day. The dose was reduced by half in the event of fluid-related side effects. The target daily dose of approximately 0.6 mg/day is in agreement with the physiological GH production in middle-aged women (IU = 3 x mg dose). [J Clin Endocrinol Metab, 2005;90:1466-1474. 43131 (6/2005)] Summary Interview

Obesity - interval walking - 49462

Interval walking for 60 minutes, 5 days per week in type 2 diabetics, defined as alternating between 3 minutes of high speed walking and 3-minutes of low speed walking (high speed walking is the equivalent of the fastest speed you can possibly walk without breaking into a jog), showed statistically-significant improvements in body weight, abdominal visceral adiposity, VO2 peak, LDL-cholesterol, fasting insulin, and CGM glucose. The continuous walking group showed no improvement, but had no decline in the above parameters. The control group showed a decline in the above parameters. Summary – Interview - PubMed - [Diabetes Care, 2012 Sept 21; [Epub ahead of print]. 49462 (2/20013)] Summary Interview PubMed

Obesity - leucine, vitamin b6 - 49757

Leucine at 1.125 gm plus vitamin B6 at 15 mg twice daily in obese subjects reduced body fat. The leucine-B6 supplement combined with energy restriction of 500 kcal per day resulted in 50-80% more body weight and body fat loss compared to placebo. Leucine increases mitochondrial metabolism and fat oxidation. Leucine increases fat oxidation in skeletal muscle and fat tissue. Pyridoxal phosphate inhibits calcium influx in adipocytes and decreases fat synthesis and adipocyte lipid content. 

[Diabetes Metab Sydnr Obes, 2013 Aug 23;309-15. 49757 (10/2013)] Summary Interview PubMed

Obesity - lychee, oligonol® - 47559

Oligonol®, a polyphenol extracted from Lychee, given at dose of two 50 mg capsules two times per day after breakfast and dinner. [Journal of Functional Foods, 2009 [published ahead of print]. 47559 (12/2009)] Summary Interview

Obesity - oligofructose - 47273

Oligofructose (pre-biotic) 7 gms t.i.d. in water or beverage 30 minutes before meals. [Am J Clin Nutr, 2009; 89(6): 1751- 9. 47273 (7/2009)] Summary Interview PubMed

Obesity - restaurant food - 33864

Restaurant food - people who consumed food from restaurants more often were fatter and conversely, people who consumed food from restaurants less often were leaner; people who ate restaurant food more often consumed a greater amount of calories per kg body weight, more total fat, saturated fat and less fiber than those who ate restaurant food less often. [Obesity Res, Nov 1999;7(6):564-571. 33864 (2000)] Summary Interview

Obesity - serotonin - 30375

Serotonin production increases via tryptophan increase in the brain leads to satiety, in particular leading to a reduction in carbohydrate intake. [Intern J Obesity, 1998; 22:628-654. 30375 (1998)] Summary Interview

Obesity - soft drink - 46201

Soft drink (sugar-sweetened beverages) consumption reduction reduced obesity rates in school children. [Am J Clin Nutr, 2006 Aug;84(2):274-88. 46201 (11/2006)] Summary Interview

Obesity - sugar-sweetened beverage - 46201

Sugar-sweetened beverage consumption is a risk factor for childhood obesity. [Am J Clin Nutr, 2006 Aug;84(2):274-88. 46201 (11/2006)] Summary Interview

Obesity - television watching - 29568

Television watching (4 or more hours per day) in children increases risk of obesity. [JAMA, March 25, 1998; 279 (12):938-942. 29568 (1998)] Interview

Obesity - whole grain - 42315

Whole grain consumption was inversely correlated with weight gain. If men increased their intake of whole grains by 40 grams per day (amount in 1 cup brown rice), they would gain 1 kg LESS weight than their counterparts over time. [Am J Clin Nutr, 2004;80:1237-1245. 42315 (01/2005)] Summary Interview
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