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Expert Pearls

Poisoning (acetaminophen toxicity) - n-acetylcysteine - 50370

N-acetylcysteine may be beneficial in a wide range of conditions with oxidative stress and depleted intracellular glutathione including acetaminophen overdose, diabetic atherothrombosis, cystic fibrosis and contrast-induced nephropathy. It’s effectiveness may be dose-dependent with the degree of glutathione depletion. In acetaminophen overdose dosing has been three consecutive intravenous infusions of 150, 50, 100 mg/kg respectively each over 1 hour and oral and nebulized doses between 700-2800 mg/d. [Pharmacol Ther. 2014 Feb;141(2):150-9. 50370 (6/2014)] Interview PubMed

Poisoning (digitalis) - Magnesium

Magnesium intravenously. [J Am Coll Nutr, 1994;13(5):496-498. 21220 (1995)] Interview

Poisoning (organophosphorus insecticides) - MgS04

MgS04 4 gms I.V. in the first 24 hrs along with normal emergency protocols reduced mortality to 0% while the control group mortality was15% and reduced hospital days to 3 instead of 5 in the control group. [Human Exp Toxicol, 2004;23:565-569. 42723 (03/2005)] Summary Interview
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