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Expert Pearls

Sleep disorder - anxiety, inflammation, melatonin, pain, surgery - 50788

Melatonin given perioperatively between 2-10 mg in a single or multiple doses throughout the day, up to possibly 300 mg/kg/bw, has analgesic, anxiolytic, anti-inflammatory and sleep normalizing effects, and an excellent safety profile, any of which may significantly improve quality of life in surgical patients. [Anaesthesia. 2014 Oct;69(10):1163-71. 50788 (5/2105)] Interview PubMed

Sleep Disorder - caffeine - 23013

Caffeine containing medications may be a cause (analgesics, cold preparations may contain 30 mg of caffeine or the equivalent of a weak cup of coffee). Coffee a lesser cause. Tea and decaffeinated coffee showed no effect. [J Am Geriatric Society, 1995;43:860-864. 23013 (1996)] Summary Interview PubMed

Sleep Disorder - cherry juice, melatonin - 50021

Cherry juice (tart) Montmorency cherry concentrate administered at 30 mls twice per day, morning and evening, diluted with about 200 mls (.84 of a cup) of water, consumed about 30 minutes before breakfast and the evening meal for 7 days increased total melatonin content (aMT6s - urinary 6-sulphatoxymelatonin) in the urine and significantly increased the time in bed, total sleep time and sleep efficiency. [ J Nutr. 2011 Oct 30. [Epub ahead of print]. 50021 (2/2012)] Interview PubMed

Sleep Disorder - diet - 45792

Diet - high glycemic index meal (high glycemic index rice) 4 hours before bed shortened sleep onset time. [Am J Clin Nutr. 2007 Feb;85(2):426-30. 45792 (7/2007)] Summary Interview PubMed

Sleep Disorder - magnesium - 48503

Magnesium citrate providing 320 mg elemental magnesium daily. Five capsules daily each providing 64 mg of magnesium. Two capsules with the morning meal, one with at the noon meal, and two during the evening meal. [Magnes Res, 2010 Dec 1; 23(4): 158-68. 48503 (3/2011)] Summary Interview PubMed

Sleep Disorder - melatonin - 22042

Melatonin 1-5 mg induces an hypnotic effect when administered at 12 noon, 5:00 p.m. and 7:00 p.m., but less so when it was administered at 9:00 p.m.. [Eur J Pharmacol, 1995; 275:213-216. 22042 (1995)] Summary Interview PubMed

Sleep Disorder - melatonin - 42513

Melatonin 0.5 to 1 mg fast or controlled release on an empty stomach 20 to 30 minutes before bed time in children with circadian rhythm sleep problems and severe neuropsychiatric developmental disorders; cerebral palsy, epilepsy, autism, visual impairment, intellectual deficits and other neurological problems, usually present in combination (children with severe brain damage may require up to 6 to 10 mg and occasionally even up to 15 mg). [Developmental Medicine Child Neurology, 2004;46:776-782. 42513 (02/2005)] Summary Interview PubMed

Sleep Disorder - valerian - 50096

Valerian at 530 mg of a concentrated valerian extract (CVE) showed significant improvement in sleep quality in postmenopausal women without side effects. [Menopause, 2011 Sep;18(9):951-5. 50096 (5/2012)] Interview PubMed
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