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Expert Pearls

Alzheimers Disease - curcumin - 47274

Curcumin BCM-95 1 - 4 gm/d with food. [Journal of Clinical Psychopharmacology, 2008;28:110-13. 47274 (7/2009)] Summary Interview PubMed

Alzheimer's Disease - turmeric - 49645

Turmeric 764 mg/day (curcumin 100 mg/day) divided into two doses, after meals, if possible with warm milk to increase absorption (supplied by KANEHIDE BIO Co. LTD). No side effects were noted and there was good compliance. Turmeric may work by preventing the amyloid-β cascade, tau phosphorylation, neuroinflammation, oxidative stress, acetylcholinesterase activity, choline acetyltransferase activity, and a synthesizing enzyme for acetylcholine.

[Ayu, 2012 Oct; 33(4): 499-504. 49645 (6/2013)] Summary Interview PubMed

Alzheimer’s Disease - diet - 34806

Diet low in fat and total energy, increased in fruits, vegetables and whole grains reduces the risk of Alzheimer’s disease. J Alzheimer’s Dis 1999 1 197-201 34806 1999 Summary Interview PubMed

Alzheimer’s Disease - diet - 34806

Diet after age 60 predominant risk factor. J Alzheimer’s Dis 1999 1 197-201 34806 1999 Summary Interview PubMed

Alzheimer’s Disease - diet - 42067

Diet high in total carbohydrate (refined or unrefined) with APOE4 allele (inhibit lipid metabolism similar to a high carbohydrate diet) increases risk. Medical Hypothesis 2004 62 689-700 42067 11/2004 Summary Interview PubMed

Alzheimer’s Disease - dietary pattern - 50334

Dietary pattern that is low-fat, plant-based diet with few processed foods, includes omega-3 fatty acid (e.g., fish oil) supplements, moderate alcohol consumption, no smoking, keeping serum 25-hydroxyvitamin D levels above 30-40 ng/mL (75-100 nmol/L), and exercise on a regular basis. Rice consumption may be protective. [J Alzheimers Dis. 2014;38(3):611-20. 50334 (6/2014)] Interview PubMed

Alzheimer’s Disease - fat - 34806

Fat - high in total fat, saturated fat and cholesterol increase risk. [J Alzheimer’s Dis, 1999;1:197-201. 34806 1999)] J Alzheimer’s Dis 1999 1 197-201 34806 1999 Summary Interview PubMed

Alzheimer’s Disease - faty acids - 42067

Fatty acids - increase the omega 3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Medical Hypothesis 2004 62 689-700 42067 11/2004 Summary Interview PubMed

Alzheimer’s Disease - fish - 34806

Fish consumption reduced risk. J Alzheimer’s Dis 1999 1 197-201 34806 1999 Summary Interview PubMed

Alzheimer’s Disease - folic acid (serum) - 37878

Folic acid (serum) less than 13 nmol/L and vitamin B12 (serum) less than 251 pmol/L increases risk. [Neurology 2001;56:1188-1194 37878 2001] Summary Interview PubMed

Alzheimer’s Disease - genetics - apoe4 allele - 34806

Genetics - APOE4 allele is associated with an increased risk; only 10 % of Alzheimer’s disease is related to genetics. [J Alzheimer’s Dis, 1999;1:197-201 34806 1999] Summary Interview PubMed

Alzheimer’s Disease - ginkgo biloba - 24968

Ginkgo biloba special extract Egb 761® 240 mg/d. Pharmacopsychiat 1996 29 47-56 24968 1996 Summary Interview PubMed

Alzheimer’s Disease - ginkgo biloba - 46792

Ginkgo biloba special extract Egb 761® 240 mg/d. Alzheimer's and Dementia July 2008 4 4 Supplement, T165-T166 46792 11/2008 Summary

Alzheimer’s Disease - homocysteine - 39403

Homocysteine (a functional test for vitamin B12) is inversely related to Alzheimer’s disease/cognitive decline. Folic acid 1 mg/d, vitamin B12 500 mcg/d, vitamin B6 40 mg/d may lower homocysteine levels. Neurology 2002 58 1395-1399 39403 2002 Summary Interview PubMed

Alzheimer’s Disease - melatonin - 34948

Melatonin reduces formation of beta-amyloid. J Applied Nutr 1999 51 1 3-15 34948 2000 Summary Interview

Alzheimer’s Disease - melatonin - 45955

Melatonin 3-6 mg (fast-release) at bedtime may improve cognitive function. J Pineal Res 2007 43 4 404-409 45955 3/2008 Summary Interview PubMed

Alzheimer’s Disease - mitochondrial energy - 34948

Mitochondrial energy production deficit (acetyl-l-carnitine, CoQ10, phosphatidylserine, magnesium enhance mitochondrial ATP production). J Applied Nutr 1999 51 1 3-15 34948 2000 Summary Interview

Alzheimer’s Disease - nadh - 24840

NADH 2 - 5 mg tablets/d. Annals of Clinical and Laboratory Science 1996 26 1 1-9 24840 1996 Summary Interview PubMed

Alzheimer’s Disease - nadh - 34948

NADH 2 - 5 mg tablets/d. J Applied Nutr 1999 51 1 3-15 34948 2000 Summary Interview

Alzheimer’s Disease - nutraceutical combination

Nutraceutical Combination - Folic acid 400 mcg/d, vitamin E 30 IU/d, vitamin B12 6 mcg/d, S-adenosyl methionine 400mg/d, N-acetylcysteine 600mg/d and acetyl-L-carnitine 500 mg/d in 2 pills per day taken at any time improved cognition and mood. [J Alzheimer's Dis Other Demen, Feb-Mar 2009;24(1):27-33. Epub 2008 Dec 3 ] Summary Interview PubMed

Alzheimer’s Disease - nutraceutical combination - 46908

Nutraceutical Combination - Folic acid 400 mcg/d, vitamin E 30 IU/d, vitamin B12 6 mcg/d, S-adenosyl methionine 400mg/d, N-acetylcysteine 600mg/d and acetyl-L-carnitine 500 mg/d in 2 pills per day taken at any time improved cognition and mood. [ Am J Alzheimer's Dis Other Demen, Dec 2008 – Jan 2009;23(6):571-85. Epub 2008 Dec 1]. 46908 (2/2009)] Summary Interview PubMed

Alzheimer’s Disease - pesticide exposure - 34948

Pesticide exposure. J Applied Nutr 1999 51 1 3-15 34948 2000 Summary Interview

Alzheimer’s Disease - vitamin b1 - 23739

Vitamin B1 (thiamine) plasma levels significantly lower; antecdotal improvement vitamin B1 3-5 gm/d. Archives of Neurology November 1995 52 1081-1085 23739 1996 Summary Interview PubMed

Alzheimer’s Disease - vitamin b12 - 28725

Vitamin B12 normal ranges should be 600 to 2000 pg/ml. Below 550 to 600 pg/ml deficiencies start to appear in the CSF. Humans are born with serum levels of about 2000 pg/ml, which decline gradually throughout life. Medical Hypotheses 1991 34 131-140 28725 1998 Summary Interview PubMed

Alzheimer’s Disease - vitamin b12 - 37878

Vitamin B12 (serum) less than 251 pmol/L and folic acid (serum) less than 13 nmol/L increases risk. Neurology 2001 56 1188-1194 37878 2001 Summary Interview PubMed

Alzheimer’s Disease - vitamin b12 - 39403

Vitamin B12 functional deficiency occurs from Alzheimer’s disease-related oxidative stress. Neurology 2002 58 1395-1399 39403 2002 Summary Interview PubMed

Alzheimer’s Disease - vitamin B12 - 46641

Vitamin B12 - low levels associated with reduced brain volume. B12 levels >300 pmol/L (406.5 pg/ml) may be protective. Neurology 2008 71 11 826-32 46641 10/2008 Summary Interview PubMed

Alzheimer’s Disease - vitamin b3 - 42169

Vitamin B3 (niacin) from diet at 22.4 mg/d (highest quintile) compared with the 12.6 mg/d (lowest quintile) resulted in a 70% reduction in risk. J Neurol Neurosurg Psychiatry 2004 75 1093-1099 42169 12/2004 Summary Interview PubMed

Alzheimer’s Disease - vitamin e - 39518

Vitamin E high in diet reduced risk significantly. JAMA June 26 2002 287 24 3230-3237 39518 2002 Summary Interview PubMed

Alzheimer’s Disease - zinc - 24249

Zinc bound thymulin in plasma is very low. Biological Trace Element Research 1996 51 55-61 24249 1996 Summary Interview PubMed
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