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Expert Pearls

Atherosclerosis - arginine, folic acid, garlic, vitamin b6, vitamin b12 - 47355

Aged garlic extract (250 mg) plus vitamin B12 (100 μg), folic acid (300 μg), vitamin B6 (12.5 mg) and L-arginine (100 mg) in one capsule given daily in the morning. [Prev Med, 2009 June 29; [Epub ahead of print]. 47355 (2/2010)] Summary Interview PubMed

Atherosclerosis - citrulline - 48344

L-citrulline with water at 2.4 grams in the morning before breakfast and 3.2 grams in the evening before sleeping. [Int J Cardiol, 2010, Nov 8; [Epub ahead of print]. 48344 (1/2011)] Summary Interview PubMed

Atherosclerosis - dhea - 44210 / 44638

DHEA 50 mg/d (↓platelet adhesion, aggregation, ↑vasodilation, cGMP). Clin Endocrinol (Oxf), 2006 Mar;64(3):260-4. 44210/44638 [(4/2006)] Summary Interview PubMed

Atherosclerosis - folic acid - 29156

Folic acid 2.5 mg/d, pyridoxine 25 mg/d and vitamin B12 250 mcg/d regressed plaque in hypertensives and hyperhomocysteinemics. [The Lancet, January 4, 1998;351:263-264. 29156 (1998)] Summary Interview PubMed

Atherosclerosis - green tea catechins - 47757

Green tea catechins 80 to 580 mg/day once daily with meals. [Circ J, 2010 Feb 4; [Epub ahead of print]. 47757 (3/2010)] Summary Interview PubMed

Atherosclerosis - heart failure, statin - 51028

Statins - The epidemic of atherosclerosis and heart failure may be exacerbated by the widespread use of statins to lower cholesterol by inhibiting vitamin K2 synthesis which effects coronary calcification and testosterone production which is cardioprotective; decreasing selenoprotein production reduces antioxidant enzymes thereby increasing peroxidative damage to heart tissue; inhibiting coenzyme Q10 production thereby acting as a mitochondrial toxin which reduces energy production in heart tissue; and inhibits Heme A biosynthesis which also effects electron transport and energy production. [Expert Rev Clin Pharmacol. 2015 Mar;8(2):189-99. 51028 (10/2015)] Interview PubMed

Atherosclerosis - melatonin - 35206

Melatonin 6 mg/d between 9 and 10 p.m. reduced LDL oxidation in postmenopausal women. [J Pineal Res, 2000;28:136-142. 35206 (2000)] Summary Interview PubMed

Atherosclerosis - plant-based diet - 44333

Antioxidant-rich plant-based diet. [Atherosclerosis, 2005 Nov 25; [Epub ahead of print]. 44333 (2/2006)] Summary Interview PubMed

Atherosclerosis - pomegranate - 46918

Pomegranate juice 50 ml/d or pomegranate polyphenol extract 5 mL/d in a single dose with a meal. [J Agric Food Chem, 2008; 56(18): 8704-13. 46918 (3/2009)] Summary Interview PubMed

Atherosclerosis - selenium - 45088

Selenium (selenomethionine from yeast) - 55 mcg bid with lunch and dinner prevented the postprandial increase in atherogenic LDL and LDL susceptibility to oxidation. Nutr Metab Cardiovasc Dis, 2007 Feb 13; [Epub ahead of print]. 45088 [(5/2007)] Summary Interview PubMed

Atherosclerosis - vitamin c - 33975

Vitamin C 2 gm decreased platelet aggregation and the augmentation index (reduced arterial stiffness). [J Cardiovas Pharmacol 1999;34:690-693. 33975 (2000)] Summary PubMed

Atherosclerosis - vitamin c - 45084

Vitamin C 1 gm b.i.d. (with breakfast and dinner) prevented monocyte dysfunction in smokers; normal monocyte function stimulates collateral arteriogenesis. [Arterioscler Thromb Vasc Biol, 2007; 27(1): 120-6. 45084 (4/2007)] Summary Interview PubMed

Atherosclerosis - vitamin e - 30824

Vitamin E 200-400 IU/d. [J Nutr, 1998;28:1593-1596. 30824 (1999)] Summary Interview PubMed

Atherosclerosis - vitamin k - 26239 / 26230

Vitamin K insufficiency is a potential risk factor. [Calcif. Tissue Int., 1996;59:352-356. 26239/26230 (1997)] Summary Interview PubMed

Atherosclerosis - zinc - 47961

Zinc (elemental from gluconate) 45 mg per day as a gluconate, one capsule (15 mg Zn) given one hour before breakfastand two capsules given 2 h after dinner. [Am J Clin Nutr, 2010 Apr 28; [Epub ahead of print]. 47961 (9/2010)] Summary Interview PubMed
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