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Expert Pearls

Psychomotor Development - hydroxycobalamin - 49775

Hydroxycobalamin 400 ug IM once in infants with feeding difficulties, subtle neurologic symptoms, or delayed psychomotor development with biochemical signs of impaired cobalamin function, defined as a plasma tHcy concentration ≥6.5 μmol/L, showed improvement in all markers of impaired cobalamin status (ie, plasma tHcy decreased by 54%, and MMA decreased by 84%) and a median (IQR) increase in the Alberta Infants Motor Scale (AIMS) score and a higher proportion had improvements in regurgitations (69% compared with 29%, respectively). [Am J Clin Nutr, 2013 Sept 11;[Epub ahead of print]. 49775 (12/2013)] Summary Interview PubMed
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