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Expert Pearls

Nephrophathy (Contrast-Induced) - n-acetylcysteine - 50370

N-acetylcysteine may be beneficial in a wide range of conditions with oxidative stress and depleted intracellular glutathione including acetaminophen overdose, diabetic atherothrombosis, cystic fibrosis and contrast-induced nephropathy. It’s effectiveness may be dose-dependent with the degree of glutathione depletion. In acetaminophen overdose dosing has been three consecutive intravenous infusions of 150, 50, 100 mg/kg respectively each over 1 hour and oral and nebulized doses between 700-2800 mg/d. [Pharmacol Ther. 2014 Feb;141(2):150-9. 50370 (6/2014)] Interview PubMed
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