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Expert Pearls

Neuropsychiatric Disorder - alpha lipoic acid, ATP Fuel, carnitine, coq10, mitochondria, nadh - 50467

Chronic diseases of all types, including aging, result in some type of mitochondrial dysfunction. Key mitochondrial supportive nutrients (ATP Fuel®) and therapeutic dose ranges include: L-Carnitine varying from 140 mg to over 2 g per day with most recommendations in the range of 1-2 g per day in divided doses. Up to 6 g per day of dietary supplementation of L-carnitine is safe; CoQ10 has been used in doses up to 1.2 g per day. Frequent daily doses are 30-300 mg per day; Alpha lipoic acid at 200 to 600 mg per day; Microcarrier-stabilized NADH varies from 10-30 mg per day; and Lipid Replacement Therapy (NTFactor®) at 1-2 g of stabilized phospholipids. [Altern Ther Health Med. 2014 Winter; 20 (Suppl 1):18-25. 50467 (9/2014)] Interview PubMed

Neuropsychiatric Disorder - alzheimer's disease, green tea, l-theanine - 50428

L-theanine (LT), a non-essential amino acid, increases neuroinhibitory neurotransmitters (GABA and glycine) and reduces norepinephrine. LT may be neuroprotective by inhibiting glutamate release as well as increasing GABA and glycine. LT may help in Alzheimer’s treatment and prevention by reducing amyloid β levels and inhibition of amyloid β-induced neuronal cell death. Dose ranges are from 20-45 mg in a cup of green tea (to a lesser extent black tea). LT has been shown to improve cognitive function in Japanese elderly at 50 mg/d and has been used in schizophrenia in doses of 400 mg/d. 400 mg per day has been shown to be safe. [Nutr Neurosci. 2014 May 28;17(4):145-55. 50428 (8/2014)] Interview PubMed
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