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Expert Pearls

Anxiety - inflammation, melatonin, pain, sleep, surgery - 50788

Melatonin given perioperatively between 2-10 mg in a single or multiple doses throughout the day, up to possibly 300 mg/kg/bw, has analgesic, anxiolytic, anti-inflammatory and sleep normalizing effects, and an excellent safety profile, any of which may significantly improve quality of life in surgical patients. [Anaesthesia. 2014 Oct;69(10):1163-71. 50788 (5/2105)] Interview PubMed
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