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Expert Pearls

Chronic Disease - alpha lipoic acid, ATP Fuel, carnitine, coq10, mitochondria, nadh - 50467

Chronic diseases of all types, including aging, result in some type of mitochondrial dysfunction. Key mitochondrial supportive nutrients (ATP Fuel®) and therapeutic dose ranges include: L-Carnitine varying from 140 mg to over 2 g per day with most recommendations in the range of 1-2 g per day in divided doses. Up to 6 g per day of dietary supplementation of L-carnitine is safe; CoQ10 has been used in doses up to 1.2 g per day. Frequent daily doses are 30-300 mg per day; Alpha lipoic acid at 200 to 600 mg per day; Microcarrier-stabilized NADH varies from 10-30 mg per day; and Lipid Replacement Therapy (NTFactor®) at 1-2 g of stabilized phospholipids. [Altern Ther Health Med. 2014 Winter; 20 (Suppl 1):18-25. 50467 (9/2014)] Interview PubMed

Chronic Disease - Diet

Diet - 1 serving of fruit/vegetable (80 gms) can reduce coronary heart disease mortality by 10% for middle aged adults and about 7% for older people; reduces ischemic stroke 6% and 4% respectively. [Aust N Z J Public Health, 2006 Feb;30(1):26-31. 44474/45018 (7/2006)] Summary Interview

Chronic Disease - Diet - 2

Diet - model after chimp diet composed of 75% ripe wild fruit; 20% of leaves and pith; and 5% foods of animal origin (by dry weight ‘wild fruit’ contains fats, proteins, carbohydrates, digested and undigested fiber in the approximate proportions 5 : 7 : 14 : 17 : 17). About half of the fat component is EFAs (23% linoleic and 16% alpha-linolenic). To mimic the ‘modern’ chimpanzee diet eat organic fruit, brazil nuts, flax seeds, avocados, eggs, grass-fed bison and 20% of diet as big leafy green salads. [Med Hypothesis, 2005;64(4):882. 43129 (6/2005)] Summary Interview

Chronic Disease - Diet - 3

Diet - More plant protein decreases insulin hypersecretion while animal protein increases insulin hypersecretion; plant protein leads to less excretion of calcium and achieves calcium balance with lower calcium intake than an animal protein rich diet. [Nutrition Research, 1994;14(12):1853-1895. 22584 (1996)] Summary Interview

Chronic Disease - Exercise

Exercise - daily participation in the prescribed exercise program has highly beneficial effects on cardiovascular diseases, diabetes, arthritis, hyperlipidemia, depression, cancer and COPD by: a) Increasing blood supply to all organs and tissues; b) By improving muscle/tendon/ligament/strength, mobility and flexibility; c) By the release of endorphins (the feel good hormones); d) By increasing bone formation; and e) By stimulating creativity. Exercise restores/improves the function of all body tissues and organs. [The Physician and Sports Medicine, February, 1996;24(2):72-78. 24181B (1996)] Summary Interview

Chronic Disease - Folic acid

Folic acid fortification may correct nucleotide polymorphisms (SNPs) that may reduce the risk to cardiovascular disease, cancer and birth defects. [BMJ USA, March 2004;4:127-131. 41556 (2004)] Summary Interview

Chronic Disease - Folic acid - 2

Folic acid fortification with pteroylmonoglutamic acid (PGA) is not the natural form of the folic acid but is cheap and stable. 5-methyl-H4folate (5-MTHF) is the major transport form of the vitamin outside the cell. A single dose of 400 (or less) micrograms of PGA is converted efficiently into 5-methyl-H4folate during absorption. The absorption and biotransformation process is saturated at this 400 microgram dose, and anything higher intake will lead to unmodified PGA appearing in the blood which have unknown toxicity. [BMJ USA, March 2004;4:127-131. 41556 (2004)] Summary Interview
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