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Expert Pearls

Chronic Fatigue Syndrome (see fatigue) - Acetyl-carnitine

Acetyl-carnitine 4 gm/d. [Carnitine Today, 1997;Chapter 10:195-213. 29191 (1998)] Summary Interview

Chronic Fatigue Syndrome (see fatigue) - Acetyl-carnitine - 2

Acetyl-carnitine serum levels are low while serum free carnitine levels are frequently normal. [Carnitine Today, 1997;Chapter 10:195-213. 29191 (1998)] Summary Interview

Chronic Fatigue Syndrome (see fatigue) - D-ribose

D-ribose at 5 gms t.i.d. with or without meals for approximately 3 weeks (loading dose) then 5 gm b.i.d. for up to six weeks (can stop if no benefit). [J Altern Complement Med, 2006 Nov;12(9):857-62. 44986/45599 (4/2007)] Summary Interview

Chronic Fatigue Syndrome (see fatigue) - Diet

Diet - eliminate caffeine, sucrose and eat a higher protein and lower carbohydrate diet x 2 weeks. [The Nutrition Report, March 1991;9(3):17,24. 12081 (1996)] Summary Interview

Chronic Fatigue Syndrome (see fatigue) - Exercise

Exercise in a graded fashion; staying at same level of exercise if fatigue worsens (small minority of subjects) then increasing with symptom stabilization. [British Medical Journal, June 7, 1997;314:1647-1652. 27549 (1997)] Summary Interview

Chronic Obstructive Pulmonary Disease (COPD) - soy - 47315

Soy consumption (i.e. tofu, bean sprouts, soy milk) reduced respiratory symptoms, improved lung function with no side effects. [Respir Res, 2009;10:56. 47315 (8/2009)] Summary Interview PubMed

Chronic Obstructive Pulmonary Disease (COPD) - beta-agonist (chronic) therapy - 21987

Beta-agonist (chronic) therapy may increase bronchospasm by suppressing endogenous catecholamines. [Arch Intern Med, March 13, 1995;155: 496-500. 21987 (1996)] Summary Interview PubMed

Chronic Obstructive Pulmonary Disease (COPD) - beta-hydroxy-β-methylbutyrate - 44762

Beta-hydroxy-β-methylbutyrate (HMB) 1.5 gm b.i.d through a feeding tube reduced inflammation and improved ventilator weaning. [Asia Pac J Clin Nutr, 2006;15(4): 544-50. 44762 (2/2007] Summary Interview PubMed

Chronic Obstructive Pulmonary Disease (COPD) - magnesium sulfate - 21987

Magnesium sulfate 1.2 gm I.V. over 20 minutes after using a standard beta-agonist treatment in acute exacerbations increased improve peak expiratory flow. [Arch Intern Med, March 13, 1995;155:496-500. 21987 (1996)] Summary Interview PubMed

Chronic Obstructive Pulmonary Disease (COPD) - n-acetylcysteine - 50368

N-acetylcysteine (NAC) 600 mg two times daily in 120 stable Chinese COPD patients in a double-blind controlled trial for one-year showed NAC reduced exacerbations and prolonged the time to the first exacerbation in high-risk COPD patients. These benefits were not observed in the low-risk COPD patients. Chronic use of NAC is a safe and well-tolerated treatment. No major adverse effects were reported in this study. [Chest. 2014 May 15. [Epub ahead of print] 50368 (6/2014)] Interview PubMed

Chronic Obstructive Pulmonary Disease (COPD) - n-acetylcysteine - 41843

N-acetylcysteine 1800 mg/d improved quadricep endurance performance. [Am J Respir Crit Care Med, 2004; 169:1022-1027.-R71. 41843 (09/2004)] Summary Interview PubMed
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