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Expert Pearls

Crohns Disease - vitami d - 50292

Vitamin D3 50,000IU orally weekly for 8 weeks to achieve a serum concentration of 30-36 ng/mL or Crohn’s disease patients with a serum 25(OH)D concentration below 3ng/mL may be given 5000IU per day; patients with levels between 4-9ng/mL given 4000IU/day; patients with levels between 10-15ng/mL given 3000IU/day; and those with levels above 16ng/mL may be prescribed between 1000-2000IU/day. Thereafter a maintenance dose of between 1500-2000IU/d or a dose to keep the serum level between 30-36 ng/mL with an upper range of ≥ 60 ng/mL and a toxicity range between 100-150 ng/ml. Vitamin D3 levels should be monitored every 3-6 months to maintain levels between 30-36 ng/mL. The dosages should be multiplied by a factor of 1.5-3 in patients with body mass index >30. [JPEN J Parenter Enteral Nutr, 2013 Oct 23. [Epub ahead of print] 50292 (4/2014)] Interview PubMed

Crohn's Disease - fatigue, vitamin b1 - 50512

Vitamin B1 (thiamine) between 600 mg/day (60 kg = 132 lbs) to 1,500 mg/day (90 kg = 198 lbs) taken orally in patients with Crohn’s Disease or Ulcerative Colitis with normal blood levels of thiamine and thiamine pyrophosphate showed regression of fatigue. Too much thiamine can cause a reversible tachycardia and sleep disturbance. [Altern Complement Med. 2013 Aug;19(8):704-8. 50512 (11/2014)] Interview PubMed

Crohn’s Disease - Fructo-oligosaccharides

Fructo-oligosaccharides 15 mg/d. [Gut, 2006;55(3):348-55. 44075 (4/2006)] Summary

Crohn’s Disease - Omega-3 fatty acids

Omega-3 fatty acids 2.7 gm/d (EPA 180 mg/DHA 120 mg per capsule; 9 capsules/d). [NEJM, June 13, 1996;334(24): 1557-60. 25051 (1996)] Summary

Crohn’s Disease - Omega-3 fatty acids - 2

Omega-3 fatty acids 3 gms or more per day; reduce omega-6 fatty acids. [Aliment Pharmacol Ther, 2005 Dec;22(11-12):1121-8. 44467/44280 (1/2006)] Summary
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