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Expert Pearls

Addiction - cocaine, n-acetylcysteine - 50973

N-acetylcysteine (NAC) 1200-2400 mg per day with or without food helped those who had quit cocaine stay away from trying it again and reduced the craving. NAC increases cystine which displaces glutamate in brain cells, bringing back glutamate balance, and reducing cravings and impulsivity. [Am J Addict. 2013 Sep-Oct;22(5):443-52. 50973 (10/2015)] Interview PubMed

Addiction - dhea - 45738

DHEA 25-50 mg/d in chronic opioid users may be beneficial. J Pain. Dec 2006 7 12 901-7 45738 5/2007 Interview PubMed

Addiction - dheas - 45738

DHEAS levels in opioid users were low and frequently undetectable. 45738 [J Pain, Dec 2006;7(12):901-7] 5/2007 Interview PubMed

Addiction - n-acetylcysteine - 45645

N-acetylcysteine 600 mg b.i.d. - 1200 mg t.i.d. has reduced cocaine and heroin craving. Am J Psychiatry 2007 164 7 1115-7 45645 [Am j Psychiatry, 2007;164(7):1115-7] 11/2007 Summary Interview PubMed
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