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Expert Pearls

Cystic Fibrosis - beta-carotene - 39678

Beta-carotene 20 mg t.i.d. (0.6 mg/kg t.i.d.) lowered plasma tumor necrosis factor-alpha and malondialdehyde. [Acta Paediatr, 2002;91:793-798. 39678 (2003)] Summary Interview PubMed

Cystic Fibrosis - n-acetylcysteine - 50370

N-acetylcysteine may be beneficial in a wide range of conditions with oxidative stress and depleted intracellular glutathione including acetaminophen overdose, diabetic atherothrombosis, cystic fibrosis and contrast-induced nephropathy. It’s effectiveness may be dose-dependent with the degree of glutathione depletion. In acetaminophen overdose dosing has been three consecutive intravenous infusions of 150, 50, 100 mg/kg respectively each over 1 hour and oral and nebulized doses between 700-2800 mg/d. [Pharmacol Ther. 2014 Feb;141(2):150-9. 50370 (6/2014)] Interview PubMed

Cystic Fibrosis - vitamin d - 47329

Vitamin D3 50,000 IU weekly provided better blood levels than vitamin D2 50,000 IU weekly, though both raised levels significantly. [J Clin Endocrinol Metab, 2009;94(6):2037-43. 47329 (9/2009)] Summary Interview PubMed
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