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Expert Pearls

Endothelial Function - alpha lipoic acid - 50564

Alpha lipoic acid (ALA) at 1800 mg per day in obese subjects with hypertension, diabetes mellitus, or hypercholesterolemia lead to modest weight loss. [Curr Med Chem. 2014 Jul 6. [Epub ahead of print] 50564 (11/2104)] Interview PubMed

Endothelial Function - arginine - 32138

Arginine (L-) 5-8 gm/d is minimum effective dose; 18-20 gm/d is a maximum effective dose without significant side effects. [Cardiology 1999;90:153-159. 32138 (1999)] Summary Interview

Endothelial Function - calcium - 36718 / 39257

Calcium 1000 mg/d plus 2 mg estriol increased BMD and improved endothelial function. [J Am Geriatri Soc, April 2002;50(4):777-778. 36718 / 39257 (2002)] Summary

Endothelial Function - citrulline - 48344

L-citrulline with water at 2.4 grams in the morning before breakfast and 3.2 grams in the evening before sleeping. [Int J Cardiol, 2010, Nov 8; [Epub ahead of print]. 48344 (1/2011)] Summary Interview PubMed

Endothelial Function - coenzyme q10 - 45545

Coenzyme Q10 100 mg t.i.d. with meals improved endothelial function and extracellular SOD. [Eur Heart J, 2007 Jul 19; [Epub ahead of print]. 45545 (9/2007)] Summary Interview

Endothelial Function - curcumin - 49419

Curcumin (Theracurumin®; Theravalues Corp, Japan), at 150 mg per day divided into 6 capsules (1 capsule contained 25 mg curcumin), 3 capsules after breakfast and 3 after dinner, improved endothelial function. [Nutr Res, 2012 Oct; 32(10): 795-9. 49419 (12/2012)] Summary Interview PubMed

Endothelial Function - diet - 28669

Diet - high fat meal increases endothelial dysfunction. [JAMA, November 26, 1997;278(20):1682-1686. 28669 (1998)] Summary Interview

Endothelial Function - diet / trans fatty acids - 42103

Diet rich in trans fatty acids (margarine, commercially baked products, and deep-fried fast food) impairs endothelial function. [Am J Clin Nutr, 2004;80:1029-1035. 42103 (11/2004)] Summary Interview

Endothelial Function - folic acid - 22602 / 22112

Folic acid 5 mg/d and vitamin B6 250 mg/d. [Eur J Clin Investigation, 1995;25:176-181. 22602/22112 (1996)] Summary Interview

Endothelial Function - garlic - 49298

Garlic - aged garlic extract compound (Kyolic Formula 109) delivering1200 mg of AGE and 120 mg of CoQ10 (4 tablets per day). [Nutrition, 2012 Aug 1; [Epub ahead of print]. 49298 (8/2012)] Summary Interview PubMed

Endothelial Function - green tea catechins - 47757

Green tea catechins 80 to 580 mg/day once daily with meals. [Circ J, 2010 Feb 4; [Epub ahead of print]. 47757 (3/2010)] Summary Interview PubMed

Endothelial Function - isoflavone - 46714

Isoflavone 80 mg/day in a single dose with or without food. [Eur Heart J, 2008 Sept 23; [Epub ahead of print]. 46714 (12/2008) Summary

Endothelial Function - magnesium - 48178

Magnesium pidolate, a bioavailable organic salt, given by mouth at a dose of 4.5 grams per day providing 368 milligrams of elemental magnesium in two divided doses (morning and evening), with or without meals improve endothelial function. [Magnes Res, 2010 Aug 24; [Epub ahead of print]. 48178 (10/2010)] Summary Interview PubMed

Endothelial Function - omega-3 fatty acids - 46407

Omega-3 fatty acids (2 g/d DHA and 3 g/d EPA, fish oil) in 3 divided doses with meals increased stroke volume and cardiac output. [Eur J Appl Physiol, 2008 June 18; [Epub ahead of print]. 46407 (8/2008)] Summary Interview

Endothelial Function - tea (black) - 45109

Tea (black) - the addition of milk negates the enhancement of nitric oxide and improvement in endothelial function that plain tea provides by milk caseins forming complexes with the protective tea catechins. [Eur Heart J, 2007; 28(2): 219-23. 45109 (6/2007)] Summary Interview

Endothelial Function - vitamin c - 28669

Vitamin C 1,000 mg/d and vitamin 800 IU/d after high fat meal. [JAMA, November 26, 1997;278(20):1682-1686. 28669 (1998)] Summary Interview

Endothelial Function - vitamin c - 29230 / 29224

Vitamin C 2 gm/d in heart failure patients. [Circulation, 1998;97:363-368. 29230/29224 (1998)] Summary Interview

Endothelial Function - vitamin c - 33832

Vitamin C 3 gm in an intravenous infusion of 100 ml 0.9% saline over 10 minutes. [Eur Heart J 1999;1676-1680. 33832 (2000)] Summary Interview

Endothelial Function - vitamin c - 33832

Vitamin C .5-2gm/d. [Eur Heart J, 1999;1676-1680. 33832 (2000)] Summary Interview

Endothelial Function - vitamins c - 40905

Vitamins C 500 mg/d and E 400 IU/d. [Circulation, 2003;108:1059-1063. 40905 (2003)] Summary Interview

Endothelial FunctionDiet - fruits / vegetables / fish - 42103

Diet rich in fruits (antioxidants), vegetables (folic acid), and fish (n-3 fatty acid) benefits endothelial function. [Am J Clin Nutr, 2004;80:1029-1035. 42103 (11/2004)] Summary Interview
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