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ja_mageia

Expert Pearls
Letter "M"
Categories beginning with "M"

MATHS

Meibomian Gland Dysfunction

Melanoma

Melatonin

Memory

Menopausal Symptoms

Menopause

Menstrual Pain

Mental Function

Mercury Exposure/Toxicity

Metabolic Syndrome

Microalbuminuria

Migraine Headache

Mind-Body

Miscarriage

Mitochondrial Cytopathy

Mitral Valve Prolapse

Mobility

Mood Disorders

Mortality

Mortality (from cardiovascular disease)

Motion Sickness

Mucositis (radiation-induced)

Multiple Sclerosis

Muscle Damage (exercise-induced)

Muscle Pain

Muscle Soreness

Muscle Strength

Muscle Wasting

Muscular Dystrophy

Myelofibrosis

Myocardial Infarction

Myopathy (skeletal)

Myositis

 

Entries beginning with "M"

MATHS - Lactose intolerance

Lactose intolerance induced chronic illness described as MATHS - Muscle Pain, Allergy, Tachycardia and Tiredness, Headache caused by Sugar overload in the intestine. Diagnosed by the breath hydrogen test. [The Lancet, April 15, 2000;355:1330. 35005 (2000)] Summary Interview

Meibomian Gland Dysfunction - Linoleic acid/Gamma-linolenic acid

Linoleic acid (28.5 mg) and gamma-linolenic acid (15 mg) 1 tablet daily improved eyelid inflammation. [Cornea, 2007; 26(3): 260-4. 45286 (8/2007)] Summary Interview

Melanoma - Sun exposure

Sun exposure - intermittent high exposure to sunlight may increase melanoma risk. [Br Med J, July 10, 1999; 319:114-116. 32587 (1999)] Summary Interview

Melanoma - Sun tanning

No known cause. Occurs much more frequently on sun exposed versus non-sunexposed areas. Some protection with tanning. [Seminars in Oncology, December, 1996;23(6):650-666. 26818 (1997)] Summary Interview

Melatonin - Glutathione/Mannitol/Vitamin E

Free radical scavenger 5 x greater than glutathione and 15 x greater than mannitol; as good as vitamin E protecting against lipid peroxidation; better than vitamin E as a peroxyl radical scavenger; a water soluble and lipid soluble antioxidant. [Rev Environ Health, 1994;10(3-4):171. 21990 (1995)] Summary Interview

Memory - cocoa, phosphatidylserine - 49578

Two cocoa flavored chews per day, containing 100 mg of soy-derived phosphatidylserine per chewable improved ADHD symptoms and short-term auditory memory; improved functioning and quality of life in school and at home; improved classroom behavior and social skills; and showed improvements in putting things back in their proper places at home. Compliance was excellent and there were no side effects.

[J Hum Nutr Diet, 2013 March 17; [Epub ahead of print]. 49578 (7/2013)] Summary Interview PubMed

Memory - cognition, dha - 49567

DHA at 1.16 g/d from a fish source in capsules with a meal in a single or divided dose improved memory and reaction times of memory and that gender modulated the responses. Reaction times of episodic and working memory improved in the total group but in women, episodic memory improved significantly. ApoE did not modulate the responses to DHA treatment with the group as a whole, but when stratified for gender, ApoE may have resulted in greater improvements in reaction times in men who were carriers of the ApoE4 allele. Gender affected cognitive responses to DHA treatment. [Am J Clin Nutr, 2013 March 20; [Epub ahead of print]. 49567 (4/2013)] Summary Interview PubMed

Memory - concord grape juice - 47663

Concord grape juice 2½ cups per day taken in divided doses with the morning, midday, and evening meals improved memory function. [Br J Nutr, 2009 Dec 23:1-5; [Epub ahead of print]. 47663 (2/2010)] Summary Interview PubMed

Memory - creatine monohydrate - 45660

Creatine monohydrate 5 gm q.i.d. in elderly benefitted verbal and visual short-term memory and long-term memory (with or without meals). [Neuropsychol Dev Cogn B Aging Neuropsychol Cogn, 2007; 14(5): 517-28. 45660 (1/2008)] Summary Interview

Memory - docosahexaenoic acid, eicosapentaenoic acid, phosphatidylserine - 48010

Phosphatidylserine (PS) 300 mg and docosahexaenoic (DHA) + eicosapentaenoic acid (EPA) 79 mg given as a daily in a DHA:EPA ratio of 3:1 given in three doses with meals. [Dement Geriatr Cogn Disord, 2010;29(5):467-474. 48010 (9/2010)] Summary Interview PubMed

Memory - multivitamin - 49384

A multivitamin (Swisse Women’s 50+ formulation) designed for women aged over 50 years was given to women 64-82 years of age for 16 weeks once daily with breakfast improved spatial working memory performance.

[Physiol Behav, 2012, Aug 23;107(3):346-354 49384 (11/2012)] Summary Interview PubMed

Memory - nutraceutical combination - 46908

Nutraceutical Combination - Folic acid 400 mcg/d, vitamin E 30 IU/d, vitamin B12 6 mcg/d, S-adenosyl methionine 400mg/d, N-acetylcysteine 600mg/d and acetyl-L-carnitine 500 mg/d in 2 pills per day taken at any time improved cognition and mood. [J Alzheimer's Dis Other Demen, Feb-Mar 2009;24(1):27-33. Epub 2008 Dec 3 ] [ Am J Alzheimer's Dis Other Demen, Dec 2008 – Jan 2009;23(6):571-85. Epub 2008 Dec 1]. 46908 (2/2009)] Summary Interview PubMed

Memory - nutraceutical vombination - 46908

Nutraceutical Combination - Folic acid 400 mcg/d, vitamin E 30 IU/d, vitamin B12 6 mcg/d, S-adenosyl methionine 400mg/d, N-acetylcysteine 600mg/d and acetyl-L-carnitine 500 mg/d in 2 pills per day taken at any time improved cognition and mood. [J Alzheimer's Dis Other Demen, Feb-Mar 2009;24(1):27-33. Epub 2008 Dec 3 ] [ Am J Alzheimer's Dis Other Demen, Dec 2008 – Jan 2009;23(6):571-85. Epub 2008 Dec 1]. 46908 (2/2009)] Summary Interview PubMed

Memory - thyroid function - 45945

Thyroid function - high concentrations of TSH were negatively associated with memory and verbal and quantitative skills in children. [Clin Endocrinol (Oxf), 2007 Jun;66(6):890-8. 45945 (1/2008)] Summary Interview

Memory - walking - 23627

Walking > 1000 steps per day improves memory in cardiac patients. [J Int Med, 1995;238:423-428. 23627 (1995)] Summary Interview

Menopausal Symptoms - climacteric - dhea - 48915

DHEA 10 mg/d orally (female). [Climacteric, 2011 Dec;14(6):661-8. 48915 (1/2012)] Summary Interview PubMed

Menopausal Symptoms - isoflavone - 44038 / 44438

Isoflavone - 300 mg of the standardized soy extract with a medium dose of 120 mg isoflavones/d as glycoside and aglycone (60 mg twice a day) reduced vasomotor symptoms with no endometrial proliferation, but did not improve signs of atrophic vaginitis. [Maturitas, 2006 Jan 10;53(1):49-58. Epub 2005 Oct 27. 44038 / 44438 (4/2006)] Summary Interview PubMed

Menopausal Symptoms - magnesium oxide - 48726

Magnesium oxide 400 mg escalating to 800 mg by mouth daily, many times taken before bed reduced hot flash frequency and severity. [Support Care Cancer, 2011 June;19(6):859-63. 48726 (08/2011)] Summary Interview PubMed

Menopausal Symptoms - soy protein - 45256

Soy protein - 25 gms of soy nuts (½ cup = 101 mg of aglycone isoflanvones). [Arch Int Med, 2007;167:1060-1067; J Womens Health (Larchmt), 2007;16(3): 361-9. 45256 (1/2008)] Summary Interview PubMed

Menopausal Symptoms - st. john's wort - 47859

St John's wort extract at 20 drops (1 milligram) three to four times daily with or away from meals reduced hot flashes. [Menopause, March 2010, 17(2):326-31. 47859 (6/2010)] Summary Interview PubMed

Menopause (surgical) - Testosterone

Testosterone replacement at 300 micrograms per day from a transdermal testosterone patch significantly increased sexual desire, satisfying sexual activity and reduced personal distress. Median free testosterone levels were within the upper part of the young female reference range after testosterone replacement. [Arch Intern Med, July 25, 2005;165:1582-1589. 43504 (9/2005)] Summary Interview

Menopause - Hormone replacement therapy

Hormone replacement therapy (estradiol 1-2 mg/d plus synthetic progestins) reduced risk of cognitive impairment by 64%. [Menopause, 2005;12(1):12-17. 43029 (5/2005)] Summary Interview

Menopause - klamath microalgae extract - 48291

Klamath microalgae extract, Klamin® 1 tablet (800 mg) 1 hour after breakfast and 1 tablet an hour before dinner in menopausal women. [Minerva Ginecol, 2010;62(5):381-8. 48291 (11/2010)] Summary Interview PubMed

Menopause - sleep, valerian - 50096

Valerian at 530 mg of a concentrated valerian extract (CVE) showed significant improvement in sleep quality in postmenopausal women without side effects. [Menopause, 2011 Sep;18(9):951-5. 50096 (5/2012)] Interview PubMed

Menopause - Sun exposure

Early menopause 1) inadequate sun exposure leads to earlier menopause; 2) women whose mothers experienced menopause at a younger age (<50) are more likely to experience early menopause; 3) lower socioeconomic status (not owning a house) is associated with earlier menopause; 4) women who report heavy or very heavy premenopausal lifelong physical activity are more likely to report early menopause compared to those who report light-normal physical activity. [Maturitas. 2005 Nov-Dec;52(3-4):235-48. 44358 (1/2006)] Interview

Menstrual Pain - ginger - 51077

Ginger capsules 250 mg each before breakfast, lunch and dinner starting the day before menstrual bleeding starts till day 3 of the cycle resulted in a remarkable decrease in the amount of hemorrhage per menstrual cycle in participants receiving ginger during the three months of intervention. [Phytother Res. 2015 Jan;29(1):114-9. 51077 (1/2016)] Interview PubMed

Mental Function - Walking

Walking > 1000 steps per day improves mental function in cardiac patients. [J Int Med, 1995;238:423-428. 23627 (1995)] Summary Interview

Mercury Exposure/Toxicity - Antibiotic resistance

Antibiotic resistance - in monkeys amalgam mercury increases the proportion of intestinal bacteria that are resistant to mercury, and these same bacteria then become resistant to oral antibiotics. [The FASEB Journal, April, 1995;9:504-508. 22436/24423 (1997)] Summary Interview

Mercury Exposure/Toxicity - Cardiomyopathy

Cardiomyopathy - toxic metal accumulation in cardiac muscle of mercury and antimony more than 10,000 times normal. [J Am Coll Cardiol 1999;33: 1578-83. 32141 (1999)] Summary Interview

Mercury Exposure/Toxicity - Fecal excretion

Fecal excretion of mercury is significant with chronic or acute exposure. [The FASEB Journal, April, 1995;9:504-508. 22436/24423 (1997)] Summary Interview

Mercury Exposure/Toxicity - Mercury

Mercury - amalgam should be substituted gradually over time with new and improved materials; the Restoration of teeth using silver amalgam or the removal of amalgam restorations during the period of pregnancy or nursing should be avoided. [Biol Trace Elem Res. 2005 Aug;106(2): 145-52. 43773 (12/2005)] Summary Interview

Mercury Exposure/Toxicity - Mercury - 2

Mercury leaks from dental amalgams and mercury levels increase according to the number of dental amalgam surfaces for all the anatomic sites that were investigated (brain frontal cortex, pituitary gland, thyroid, and kidneys). [Am J Forensic Med Pathol, 2006 Mar;27(1):42-5. 44204/ 44745 (5/2006)] Summary Interview

Mercury Exposure/Toxicity - Mercury - 3

Mercury in the urine samples from dentists were about three times higher than non-exposed matched controls (6.2±3.5 µg/l and 1.97±0.9 µg/l, respectively) (p<0.001). Dentists are occupationally exposed to Hg and they may be under risk of chronic exposure compared to non-occupationally exposed people in the normal population. [Hum Exp Toxicol. 2005 Aug;24(8):383-8. 43780 (2/2006)] Summary Interview

Mercury Exposure/Toxicity - Mercury - 4

Mercury in amalgams is not inert and is released and stored in significant concentrations in soft tissue such as the brain, kidney and liver. Blood levels of mercury are poor indicators of mercury exposure. [The FASEB Journal, April, 1995;9:504-508. 22436/24423 (1997)] Summary Interview

Mercury Exposure/Toxicity - Mercury - 5

Mercury exposure to dental personnel can increase the risk to infertility and neurobehavioral problems. [The FASEB Journal, April, 1995;9:504-508. 22436/24423 (1997)] Summary Interview

Mercury Exposure/Toxicity - Mercury - 6

Mercury release from mercury vapor in dental offices occurred at a rate of 60 mg of mercury per dentist, per day. This was in addition to mercury in the liquid and solid components of the waste water from the offices. [Arch Environ Health, July/August, 1996;51(4):335-337. 25593 (1997)] Summary Interview

Mercury Exposure/Toxicity - Mercury - 7

Mercury vapor inhalation in animals produces a molecular lesion in brain protein metabolism which appears to be identical to a lesion present in 90% of Alzheimer's disease brains. [The FASEB Journal, April, 1995;9:504-508. 22436/24423 (1997)] Summary Interview

Metabolic Syndrome - beans, rice - 48826

Beans - Substituting one serving of beans for one serving of white rice was associated with a 35% lower risk of the metabolic syndrome. [Am J Clin Nutr, 2011;94(3):869-76. 48826 (10/2011)] Summary Interview PubMed

Metabolic Syndrome - Diet

Diet - rye bread and pasta-based carbohydrate modification enhances early insulin secretion in persons with the metabolic syndrome. Emphasis of rye and pasta intake coupled with effective weight maintenance may have long-term benefits on beta-cell function and glucose tolerance in individuals at high risk for developing type 2 diabetes and cardiovascular disease. [Am J Clin Nutr, 2005 Dec;82(6):1218-27. 44290 (1/2006)] Summary Interview

Metabolic Syndrome - Fruit and vegetables

Fruit and vegetable intake reduce risk. [Am J Clin Nut., 2006;84(6):1489-97. 44896 (2/2007] Summary Interview

Metabolic Syndrome - grape - 49322

Grape powder (46 grams freezed-dried; equivalent to 252 grams of fresh grapes - 1 ½ cups). [J Nutr, 2012 Sep;142(9):1626-32. 49322 (9/2012)] Summary Interview PubMed

Metabolic Syndrome - omega-3 fatty acids - 47890

Omega-3 fatty acids in 1000 mg capsules with at least 85% EPA/DHA (approximately 400 mg from EPA and 450 mg from DHA) per capsule twice daily with meals. [Clin Exp Hypertens, 2010;32(2):137-44. 47890 (7/2011)] Summary Interview PubMed

Metabolic Syndrome - Soy products

Soy products 30 gm/d (soy protein was washed and soaked for 30 minutes then boiled in water with turmeric, lemon juice and tomato paste for 10 minutes. Soy nut was used as a daily snack) reduced lipids and improved glycemic control in metabolic syndrome. Soy nut had a greater beneficial effect. [Am J Clin Nutr, 2007;85(3):735-41. 45120 (6/2007)] Summary Interview

Metabolic Syndrome - Transcendental Meditation

Transcendental Meditation (TM) 2 x per day for 20 minutes each session reduced blood pressure, blood sugar, blood insulin, insulin resistance and heart rate variability improved. [Arch Intern Med, 2006 Jun 12;166(11):1218-24. 45012 (10/2006)] Summary Interview

Metabolic Syndrome - Vitamin E

Vitamin E - alpha-tocopherol 800 mg/d and gamma-tocopherol 800 mg/d. [Free Radic Biol Med, 2008; 44(6): 1203-8. 46362 (06-14-08)] Summary Interview

Microalbuminuria - Thiamin

Thiamin 100 mg x 3 daily; one at breakfast, one in the early afternoon and one in the evening in type 2 diabetic patients (21 male, 19 female) showed improvement in kidney function reducing CVD risk. [Diabetologia, 2008 Dec 5; [Epub ahead of print]. 46881 (2/2009) Summary Interview PubMed

Migraine Headache - antioxidant, mineral, fatty acid combination - 27183

Antioxidant, mineral, fatty acid combination - 6 caps/d x 6 months, 4 caps/d during months 6-9, then 2 to 4 caps/d as a long-term dosage (1 capsule equals - evening primrose oil 300 mg, wheat-germ oil 100 mg, linseed oil 15 mg, vitamin E 25 mg, soy phosphatides 20 mg, magnesium 50 mg, vitamin C 20 mg, niacin 3mg, beta-carotene 1.3 mg, vitamin B6 .3mg). [Cephalalgia, 1997;17:127-130. 27183 (1998)] Summary Interview PubMed

Migraine Headache - coenzyme q10 - 45025

Coenzyme Q10 1-3 mg/kg in a liquid gel given in a single dose. [Headache, 2007; 47(1): 73-80. 45025 (5/2007)] Summary Interview PubMed

Migraine Headache - ginkgo, coenzyme q10, riboflavin, magnesium - 48264

Ginkgolide B at 60 mg, coenzyme Q10 10 mg, riboflavin 2.4 mg and magnesium 300 mg (daily dose) in two divided doses (one pill in the morning after breakfast and one after lunch). [Neurol Sci, 2010 Sept 25; [Epub ahead of print]. 48264 (12/2010)] Summary Interview PubMed

Migraine Headache - magnesium - 23887

Magnesium - approximately 50% of patients had low ionized magnesium levels, and of those 85% responded in minutes with an I.V. infusion of 1 gm magnesium sulfate in a 10% solution administered over 5 minutes. [Clinical Science, 1995;89:633-636. 23887 (1996)] Summary Interview PubMed

Migraine Headache - magnesium sulfate - intravenous - 37735

Magnesium sulfate (MgSO4) 1 gm I.V. over 15 minutes. [Headache, 2001;41:171-177. 37735 (2001)] Summary Interview PubMed

Migraine Headache - magnesium sulphate - 37735

Magnesium sulphate 1 gm intravenously in 10 mL of 0.9% saline. [Headache, 2001;41:171-177. 37735 (2001)] Summary Interview

Migraine Headache - melatonin - 42194

Melatonin 3 mg 30 minutes before bed reduced headaches (menstrual as well) in 1 month. [Neurology, August 2004(2 of 2);63:757. 42194 (11/2004)] Summary Interview PubMed

Migraine Headache - riboflavin (vitamin b2) - 29283

Riboflavin (vitamin B2) 400 mg/d. [Neurology, 1998;50:466-470. 29283 (1998)] Summary Interview PubMed

Mind-Body - Type A

Type A personality with and without hostility is related to a variety of chronic diseases. [World Health, March-April 1994;447(2):6-7. 20558 (1995)] Summary Interview

Miscarriage - Hyperhomocysteinemia

Hyperhomocysteinemia has been associated with recurrent pregnancy loss. [Placenta 1999;20:519-529. 32996 (1999)] Summary Interview

Mitochondrial Cytopathy - Creatine monohydrate

Creatine monohydrate 10 gm/d for five days followed by 5 gm/d for five days (and maintenance for 5 days). [Neurology March, 1999;52:854-855. 31840 (1999)] Summary Interview

Mitral Valve Prolapse - Magnesium

Magnesium deficiency is a cause of idiopathic mitral valve prolapse. [Magnesium Research, 1994(3):4:339-340. 27848 (1997)] Summary Interview

Mitral Valve Prolapse - Magnesium - 2

Magnesium 5 mg/kg/d orally is safe and may be of benefit. [Magnesium Research, 1994(3):4:339-340. 27848 (1997)] Summary Interview

Mobility - vitamin d2 - 48348

Vitamin D2 1000 IU per day with the evening meal. [J Am Geriatr Soc, 2010;58(11):2063-8. 48348 (1/2011)] Summary Interview PubMed

Mood Disorders - Exercise

Exercise - as little as 10 minutes of brisk walking can reduce psychological tension and enhance feelings of energy. Moderate intensity that elevates breathing and a degree of sweating occurs, is generally sufficient. More exercise, in general, seems to be better than just a little. People who exercised for 2 to 7 hours a week were psychologically "healthier" than people who did little or no exercise at all. Exercisers who engaged in 8 to 10 hours of activity a week were even "healthier." People should do whatever form of exercise they enjoy for as long as they can manage. Something is better than no exercise. [J Psychosomatic Med, 1996;40(2):123-141. 24395 (1997)] Summary Interview

Mood Disorders - Omega-3 fatty acids

Omega-3 fatty acids (EPA>DHA) 1 gm/d. [Am J Psychiatry, 2006 Jun;163(6): 96978. 44481/45041 (8/2006)] Summary Interview

Mood Disorders - Thiamine

Thiamine 50 mg/d. [Psychopharmacology, 1997;129:66-71. 26997 (1997)] Summary Interview

Mood Disorders - vitamin c - 49724

Vitamin C at 500 mg two times daily with or without meals in acutely hospitalized patients reduced mood disturbance and distress while 5000 IU of vitamin D had no effect. Vitamin C levels normalized while vitamin D levels remained deficient. Vitamin D may need a much larger loading dose, possibly 300,000 IU, to normalize levels in the acute care setting. [Am J Clin Nutr, 2013 July 24; [Epub ahead of print]. 49724 (9/2013)] Summary Interview PubMed

Mood Disorders - vitamin-mineral supplements - 49627

Vitamin and mineral supplementation had positive benefits on perception of stress, mild psychiatric symptoms and general mood in non-clinical, healthy adult populations in a meta-analysis of 8 double-blind randomized controlled trials. [Psychosom Med, 2013 Feb;75(2):144-53. 49627 (8/2013)] Summary Interview PubMed

Mortality (cardiovascular disease) - fiber, fruit - 50613

Fiber intake was associated with a reduction in overall mortality in high risk CVD patients and fruit intake was associated with a reduction in CVD mortality. [Am J Clin Nutr. 2014 Dec;100(6):1498-507. 50613 (1/2015)] Interview PubMed

Mortality (from cardiovascular disease) - Cholesterol

Cholesterol lowering may not lower mortality. [Nutr Metab Cardiovasc Dis, 2006 Sep;16(6):387-90. Epub 2006 Jul 26. 45469 (3/2007)] Summary Interview

Mortality (from cardiovascular disease) - Exercise

Exercise reduces mortality. There is no "threshold" level at which the benefits from physical exercise in terms of reduced mortality become apparent. Any exercise is better than no exercise, and more exercise is better than a little exercise. Moderate improvements in fitness -- particularly among those who are least fit, bring substantial reductions in mortality. In order to achieve "moderate improvements," exercise two to three times a week for 20 to 30 minutes at a level where sweating and shortness of breath occur. [The Lancet, September 5, 1998;352:759-762. 30688 (1999)] Summary Interview

Mortality (from cardiovascular disease) - Mediterranean diet

Mediterranean diet has been shown to reduce cardiac and overall mortality. [Nutr Metab Cardiovasc Dis, 2006 Sep;16(6):387-90. Epub 2006 Jul 26. 45469 (3/2007)] Summary Interview

Mortality (from cardiovascular disease) - Mediterranean diet - 2

Mediterranean diet has been shown to reduce cardiac and overall mortality. [ NEJM, June 26, 2003;348:2599-2608. 40654 (2003)] Summary Interview

Mortality (from cardiovascular disease) - nuts - 50759

The risk of death was 26% lower among men consuming nuts 5+ times per week compared to men consuming nuts <1 time/month. The inverse relation between nut consumption and death was observed mainly for cardiovascular deaths and not for cancer deaths. Regular consumption of 28 to 45 grams (1-1 ½ ounces, palm full) of tree nuts, if non-allergic, along with a healthful dietary pattern, is health promoting. Consumption should be with unsalted nuts in subjects at cardiovascular risk. [Am J Clin Nutr. 2015 Feb;101(2):407-12. 50759 (6/2015)] Interview PubMed

Mortality - exercise, physical activity, sedentary - 50906

Physical activity (non-sedentary lifestyle) reduces mortality risk. Sedentary time is positively associated with an increased risk for dying (from all-causes, cancer and cardiovascular diseases) and increasing risk for certain forms of cancer (specifically breast, colon, colorectal, endometrial, and epithelial ovarian cancer), cardiovascular disease and type 2 diabetes. Regular exercise has protective effects over the risk of premature death associated with sedentary behaviour (sitting time), but does not completely undo the harm. [Ann Intern Med. 2015 Jan 20;162(2):123-32. 50906 (8/2015)] Interview PubMed

Motion Sickness - Acupressure

P6, pulsed acupressure, relieves symptoms of car sickness, sea sickness, boat sickness and airplane sickness (the P6, Neiguan point, is on the pericardial meridian, about 3 cm from the distant palmer crease of the wrist, between the palmaris longus and flexor carpi radialis tendons). The pulsed acupressure means that the experimenter or therapist manually presses the local acupressure point at rhythmic intervals of applied one finger pressure with about 1 push per second. [J Aviation, Space and Environ Med, July 1995;66(7): 631-634. 23069 (1996)] Summary Interview

Mucositis (radiation-induced) - Glutamine

Glutamine 16 g suspension in 240 ml of normal saline given in 30-ml doses, swished for 3 minutes and expectorated 4 times per day significantly reduced the duration and severity of objective oral mucositis during radiotherapy. [Int J Radiation Oncol Biol Phys, 2000;46(3):535-539. 35019 (2000)] Summary Interview

Mucositis (radiation-induced) - Vitamin E

Vitamin E (alpha tocopherol) 100 mg (25 IU/ kg/day) b.i.d. applied topically, or chewed, swished and swallowed, improved uncomplicated mucositis in chemotherapy treated pediatric cancer patients. Vitamin E 100 mg (25 IU/ kg/day) b.i.d. P.O. after meals may prevent mucositis. [J Clin Pediatr Dent, 2007; 31(3):167-70. 45438 (10/2008)] Summary

Mucositis (radiation-induced) - Zinc sulphate

Zinc sulphate 50 mg t.i.d.. [Int J Clin Pract, July 2004;58(7):662-668. 42200 (12/2004)] Summary Interview

Multiple Sclerosis - coq10, ubiquinol - 49623

Coenzyme Q10 (ubiquinone) 500 mg daily, divided into 100 mg capsules given with meals (2 capsules with breakfast, 2 capsules with lunch and 1 capsule with dinner)significantly increased SOD activity and decreases in MDA levels without side effects.

[Int J Neurosci, 2013 May 10; [Epub ahead of print]. 49623 (6/2013)] Summary Interview PubMed

Multiple Sclerosis - fatigue, vitamin B1 - 50487

Vitamin B1 (thiamine) between 600 mg (60 kg/bw) and 1800 mg (80 kg/bw) per day in divided doses 2 to 3 times daily with the last intake of thiamine taken before 5:00 p.m.. Intramuscular injections with thiamine at 100 mg/ml every 7 days. [BMJ Case Rep, 2013 Jul 16;2013. 50487 (12/2014)] Interview PubMed

Multiple Sclerosis - Homocysteine

Homocysteine is elevated in the blood and CSF of MS patients. A functional B12 deficiency may be present and possible injectable I.M. vitamin B12 therapy may be warranted. [Biogenic Amines, 1995;11(6):479-485. 24073 (1997)] Summary Interview

Multiple Sclerosis - lipoic acid - 50444

Lipoic acid 600 mg twice daily (every 12 hours) 1 hour after meals improved serum antioxidant capacity and decreased inflammatory cytokines including INF-γ, ICAM-1 and MMP-9 with minimal side effects. [Neuroimmunomodulation. 2014;21(6):291-6. 50444 (9/2104)] Interview PubMed

Multiple Sclerosis - melatonin - 49562

Melatonin 10 mg at 6 p.m. daily increase antioxidant enzymes and decrease lipid peroxidation in progressive MS patients in 30 days. [J Neuroimmunol, Apr 15, 2013;257(1-2):97-101. 49562 (4/2013)] Summary Interview PubMed

Multiple Sclerosis - melatonin - 50581

Melatonin benefits immune and glial cells, inflammation, mitochondrial energy production, and gut permeability. Doses used are 2-10 milligrams for sleep induction, 10-20 milligrams in cancer treatment, and in late-stage cancer and motor neuron disease, up to 3,000 mg, which has produced no serious side-effects. [Mult Scler Relat Disord. 2015 Mar;4(2):112-23. 50581 (5/2015)] Interview PubMed

Multiple Sclerosis - omega-3 fatty acids, omega-6 fatty acids - 50561

Omega-3 and 6 fatty acids at approximately 16 grams (PLP10) or a daily dose of a 19.5 ml mixture of EPA (1650 mg)/DHA (4650 mg)/GLA (2000 mg)/LA (3850 mg)/total other Ω-3 (600 mg)/total MUFA (1714 mg) + total SFA (18:0 160 mg and 16:0 650 mg)/vitamin A (0.6 mg)/vitamin E (22 mg) plus pure γ-tocopherol (760 mg) plus citrus-aroma in a ratio of Ω-3 (DHA/EPA 3:1) and Ω-6 (LA and GLA 2:1) in 1:1 wt/wt reduced relapses and probability of disability progression. [BMJ Open. 2013 Apr 17;3(4). 50561 (9/2014)] Interview PubMed

Multiple Sclerosis - Picotesla electromagnetic therapy

Picotesla electromagnetic therapy - The amplitude or intensity of the magnetic field is extremely low. The electromagnetic field device produces an alternating current field of an amplitude of 7.5 picotesla (i.e., 7.5 x 10-12 Tesla or 0.000075 mG) which can be measured with a superconducting magnetometer. The amplitude of the signal field used in the treatment is several million fold weaker than the background signal of the earth's magnetic field. [Int J Neurosci, 1995;83:187-198. 24113 / Int J Neurosci, 1995;83:69-79. 23966 / Int J Neurosci, 1995;82:223-242. 22870 / Int J Neurosci,1996;84:157-164. 24371 (1997)]

Multiple Sclerosis - vitamin a - 50324

Vitamin A normalization by diet, possibly supplementation, along with vitamin D may help in multiple sclerosis. Retinoic acid appears to decrease inflammation and at the same time increase tolerance of autoimmunity. It may also help in brain protection. [CNS Drugs, 2014 Apr;28(4):291-9. 50324 (6/2014)] Interview PubMed

Multiple Sclerosis - Vitamin D

Vitamin D supplementers 40% lower risk. [Ann Pharmacother, 2006 May 9 [Epub ahead of print]. 44285 (6/2006)] Summary Interview

Multiple Sclerosis - Vitamin D - 2

Vitamin D 5000 IU/d from 20 gm of cod liver oil. [Ann Pharmacother, 2006 May 9 [Epub ahead of print]. 44285 (6/2006)] Summary Interview

Multiple Sclerosis - Vitamin D - 3

Vitamin D lower levels associated with multiple sclerosis. [J Am Diet Assoc, Mar 2006;106(3):418-24. 44101/44585 (5/2006)] Summary Interview

Multiple Sclerosis - vitamin d - 47965

Vitamin D at 2000 IU can reduce pediatric relapse by one half. Increasing vitamin D by 10 ng/mL correlated with a 34 percent decrease in the rate of subsequent relapses. [Ann Neurol, 2010;67(5):618-24. 47965 (09/2010)] Summary Interview PubMed

Muscle Damage (exercise-induced) - Cherry juice

Cherry juice (tart crushed cherries = 60 cherries per dose) 12 fl. oz. b.i.d.. [Br J Sports Med, 2006 Aug;40(8):679-83; discussion 683. Epub 2006 Jun 21. 44390/46219 (10/2006)] Summary Interview

Muscle Pain - ginger - 47991

Two grams of ground ginger (either "raw" or "heat-treated") divided into 6 capsules was taken in a single dose orally with water away from meals. [J Pain, 2010 Apr 23; [Epub ahead of print]. 47991 (8/2010)] Summary Interview PubMed

Muscle Soreness - carnitine - 25588

Carnitine (-L) 3 gm/d reduced DOMS (delayed onset muscle soreness) and CPK levels after eccentric exercise of the quadriceps (20 minute single step test). [Int J Sports Med, 1996;17:320-324. 25588 (1997)] Summary Interview PubMed

Muscle Soreness - citrulline mallate - 47908

Citrulline malate 8 grams one hour before the training session. [J Strength Cond Res, 2010 Apr 7; [Epub ahead of print]. 47908 (6/2010)] Summary Interview PubMed

Muscle Soreness - curcumin, meriva, turmeric - 49915

Curcumin as the Phytosome® delivery system 1 g twice daily (200 mg curcumin b.i.d.) before exercise and given twice daily (4 days in total). [ J Int Soc Sports Nutr 2014 Jun 18;11:31. 49915 (1/2015)] Summary Interview PubMed

Muscle Strength - vitamin d - 49628

Vitamin D3 2000 IU per day in elite ballet dancers significantly increased isometric strength and vertical jump, and significantly reduced injuries compared to controls. Vitamin D insufficiency was defined as a circulating serum 25(OH)D level between 10–30 ng/ml (25–75 nmol/l) and deficiency as a level below 10 ng/ml (25 nmol/l)).

[J Sci Med Sport, 2013 April 22; [Epub ahead of print]. 49628 (6/2013)] Summary Interview PubMed

Muscle Strength - vitamin d2 - 48348

Vitamin D2 1000 IU per day with the evening meal. [J Am Geriatr Soc, 2010;58(11):2063-8. 48348 (1/2011)] Summary Interview PubMed

Muscle Wasting - Creatine

Creatine 20 g/d loading dose x 5 days then 2-5 gm/d (questionable benefit for ‘sprinting’ exercises). [Clin J Sports Med 1998;8(4):286-297. 32700 (1999)] Summary Interview

Muscular Dystrophy - Creatine monohydrate

Creatine monohydrate 10 gm/d for five days followed by 5 gm/d for five days. [Neurology March, 1999;52:854-855. 31840 (1999)] Summary Interview

Myelofibrosis - carnitine, celecoxib, curcumin, lactoferrin, rhuepo - 50732

L-carnitine (LC) at 2 g/day each morning approximately 10.00 a.m.; curcumin 4 g/day with 2 tablets with lunch and 2 tablets with dinner; but can be taken four tablets together at lunch or dinner based on preference; lactoferrin 200 mg/day in 2 divided doses, one tablet at 10.00 a.m. and 1 tablet at 4.00 p.m. (far from meals); rHuEPO 30000 International Units once a week; and the cyclo-oxygenase inhibitor Celecoxib at 200 mg/day with a meal in a single dose. [Nutrition, 2015 Jan;31(1):239-43. 50732 (5/2015)] Interview PubMed

Myocardial Infarction - adiponectin, e-selectin, hdl, hesperidin - 50850

Hesperidin 600 mg with breakfast in myocardial infarction patients significantly decreased the serum levels of E-selectin and increased adiponectin and high-density lipoprotein cholesterol (HDL-C) concentrations. Minimal side effects were noted. [J Am Coll Nutr. 2015 May-Jun;34(3):205-11. 50850 (7/2015)] Interview PubMed
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