Expert Pearls

Abdominal Pain

Abruptio Placenta

Acne

Addiction

Adenomatous Polyps

Adrenoleukodystrophy (ALD)

Adult Respiratory Diistress Syndrome (ARDS)

Age Related Macular Degeneration

Aggression

Aging

AIDS/HIV

Akathisia (Neuroleptic-Induced)

Alcoholism

Alexithymia

Allergic Rhinitus

Allergies

Alzheimer’s Disease

Amenorrhea

Amyotrophic Lateral Sclerosis (ALS)

Anal Fissure

Anaphylaxis (Exercise-Induced)

Anemia (megaloblastic)

Anger (substance abuse)

Angina Pectoris

Anklyosing Spondylitis

Ann Allergy

Anticoagulation Therapy

Antioxidants

Anxiety

Anxiety (substance abusers)

Aphthous Stomatitis

Arrhythmias

Arthritis (polyarthritis)

Asthma

Atherosclerosis

Atopic Dermatitis / Eczema

Atrial Fibrillation

Atrophic Vaginitis

Attention-Deficit /Hyperactivity Disorder

Autism

Autoimmune Disease

Back Pain

Barrett's Esophagus

Behavior (violent)

Behavior Disorder

Behcet’s Disease

Benign Prostatic Hypertrophy (BPH)

Blepharitis

Bone Loss

Breast Feeding

Bronchiectasis

Burns

C-Reactive Protein (lowering)

Cancer

Candidiasis (oral)

Cardiac Function

Cardiomyopathy (idiopathic)

Cardiovascular Disease

Cardiovascular Surgery

Carotid Atherosclerosis

Catabolic State

Cataract

Celiac Disease

Cellulite

Cerebral Atrophy

Cerebral Hypofusion

Cerebral Palsy

Cerebral Vascular Disease

Chemoprevention

Cholestasis

Cholesterol Lowering

Chromium

Chronic Disease

Chronic Obstructive Pulmonary Disease (COPD)

Cirrhosis

Clostridium Dificille (diarrhea)

Cognition

Colic (infantile)

Common Cold

Complex Regional Pain Syndrome (CRPS)

Constipation

Contraception

Coronary Artery/Heart Disease (see also cardiovascular disease)

Cough

Cough (URI)

Cow’s Milk

Critical Illness

Crohn’s Disease

Cystic Fibrosis

Deafness

Delirium

Dementia

Dental Caries

Depression

Diabetes Mellitus

Diabetic Neuropathy

Diarrhea

Diet (general)

Docosahexaenoic Acid (DHA)

Down Syndrome

Dry Eye Syndrome

Dysfunctional Gut Syndrome

Dyslexia

Dysmenorrhea

Dyspepsia

Dysplasia (cervical)

Ear Infection

Eczema

Encephalopathy

Endothelial Function

Enteritis (radiation-induced)

Enuresis (nocturnal)

Epilepsy

Epitaxis

Erectile Dysfunction

Erythema Nodosum

Erythroderma

Estrogen Metabolism

Exercise

Exercise (duodenal ulcer)

Falling

Fatigue

Fibrinogen (lowering)

Fibrocystic Breast Disease

Fibroids (uterine)

Fibromyalgia

Fibrosis

Folic Acid

Fracture

Fracture (hip)

Fragile X Syndrome (FXS)

Gastroesophageal Reflux Disease (GERD)

Gestational Diabetes

Gingivitis (see also periodontal disease)

Glaucoma

Gout

Grave’s Disease

Grave’s Ophthalmopathy

Growth and Development

Halitosis

HDL Cholesterol (elevating)

Headache

Headache (sleep disorder)

Hearing Loss (Presbycusis)

Heart Failure

Heart Rate Variability (HRV)

Helicobacter Pylori

Hemodialysis

Hepatic Detoxification

Hepatic Fibrosis

Hepatic Hepatitis

Hepatic Steatosis (non-alcoholic fatty liver disease)

Hepatitis (Viral)

Hepatitis C

Hepatoxicity

Hereditary Hemorrhagic Telangiectasias

Hirsutism

HIV

Homocysteinemia/Homocystinuria/Hyperhomocysteinemia

Hospitalization

Hyperactivity

Hyperbilirubinemia

Hyperparathyroidism

Hypertension

Hypertension (ocular)

Hypertriglyceridemia (see triglyceride lowering)

Hypothyroidism

Ideation (paranoid)

Immune Function

Infection

Infertility (female)

Infertility (male)

Inflammation

Inflammatory Bowel Disease

Insomnia

Insulin Resistance/Hyperinsulinemia

Intermittent Claudication

Intestinal Permeability

Irritable Bowel Syndrome (IBS)

Ischemic Heart Disease

Kidney Failure / Insufficiency

Kidney Stone

Kidney Transplantation

Lactation (see breast-feeding)

Lactic Acidosis

Lactose Intolerance

Lead Excess/Poisoning

Leukemia

Leukemia - Myelogenous

Libido

Lipoprotein (a) (lowering)

Liver Disease

Longevity

MATHS

Meibomian Gland Dysfunction

Melanoma

Melatonin

Memory

Menopausal Symptoms

Menopause

Menstrual Pain

Mental Function

Mercury Exposure/Toxicity

Metabolic Syndrome

Microalbuminuria

Migraine Headache

Mind-Body

Miscarriage

Mitochondrial Cytopathy

Mitral Valve Prolapse

Mobility

Mood Disorders

Mortality

Mortality (from cardiovascular disease)

Motion Sickness

Mucositis (radiation-induced)

Multiple Sclerosis

Muscle Damage (exercise-induced)

Muscle Pain

Muscle Soreness

Muscle Strength

Muscle Wasting

Muscular Dystrophy

Myelofibrosis

Myocardial Infarction

Myopathy (skeletal)

Myositis

Nausea and Vomiting

Nausea and Vomiting (post-surgery)

Necrotizing Enterocolitis (NEC)

Nephrolithiasis

Nephropathy

Nephropathy (IgA)

Neural Tube Defect (NTD)

Neurologic Disorder

Neuromuscular Disease

Neuropathic Pain

Neuropathy

Neuropsychiatric Disorder

Neuropsychological Function

Niacin Therapy

Obesity

Obsessive Compulsive Disorder

Obstructive Sleep Apnea Syndrome

Ocular Disorder

Osteoarthritis

Osteoporosis

Otitis Media

Pain

Pain (musculoskeletal)

Pain (Neuropathic)

Pancreatitis

Panic Disorder

Parkinson's Disease

Pelvic Pain

Pemphigus (bullous)

Periodontitis /Periodontal Disease

Peripheral Vascular Disease

Pernicious Anemia

Pet Therapy

Peyronie's Disease

Phenylketonuria

Physical Performance

Phytoestrogens

Pityriasis Rubra Pilaris

Platelet Aggregation

Pneumonia

Poisoning

Polycystic Ovarian Syndrome

Portal Hypertension

Pre-Eclampsia

Pregnancy

Premature Delivery

Premature Graying

Premature Infant

Premature Rupture of Fetal Membranes (PROM)

Premenstrual Syndrome

Probiotics

Prostatitis

Psoriasis

Psychomotor Development

Pulmonary Artery Hypertension

Rabies

Radiation Exposure

Renal

Restless Leg Syndrome

Retinitis Pigmentosa

Retinopathy

Rheumatic Disease

Rheumatic Disease

Rheumatoid Arthritis

Rhinitis (allergic)

Salicylate Intolerance

Sarcoidosis

Sarcopenia

Satiety

Schizophrenia

Seasonal Affective Disorder (SAD)

Seizures

Selenium

Sepsis

Serous Otitis Media (see otitis media)

Sexual Activity/Behavior

Shock (septic shock)

Sickle Cell Anemia

Silicone Breast Implant Syndrome

Sleep Disorder

Smoking

Soy Foods

Stress

Stroke

Substance Abuse

Sudden Infant Death Syndrome

Suicide

Sunburn

Surgery

Syndrome X

Systemic Lupus Erythematosus (SLE)

Testosterone Replacement Therapy

Thalassemia

Thromboembolism

Thyroiditis

Tinnitus

Toxicity

Trans Fatty acids

Transplantation (renal)

Trauma

Triglycerides (lowering)

Tuberculosis (Mycobacteria)

Ulcer (duodenal)

Ulcer (gastric - helicobacter pylori)

Ulcer (pressure)

Ulcerative Colitis

Upper Respiratory Infection (URI)

Uric Acid

Urinary Tract Infection

Urticaria (chronic)

Uveitis

Vaginitis

Vegan / Vegetarian Diet

Ventricular Function

Very Low Birth Weight Infants

Veterinary Medicine

Violence

Vision

Vitamins

Vitiligo

Warts

Warts (genital)

Weight Gain

Wilson Disease

Xerostomia (Dry Mouth)

 

Abdominal Pain - lactobacillus reuteri - 48095

Lactobacillus Reuteri (LRD) at a dose of 2 x 108 live bacteria taken daily away from meals in a single dose significantly lowered pain intensity. [J Paediatr Child Health, 2010 Jul 8; [Epub ahead of print]. 48095 (8/2010)] Summary Interview PubMed

Abruptio Placenta - hyperhomocysteinemia - 32996

Hyperhomocysteinemia has been associated with placental abruption and infarction. 32996 [Placenta, 1999;20:519-529] 1999 Summary Interview PubMed

Acne - diet - 45462/45987

Diet - Low glycemic index and load: natural diet of unprocessed foods; e.g. lean meat and fish (to raise protein and lower carbohydrate intake); whole grain type cereals and some pasta and basmati rice (as little as possible); lots of nonstarchy vegetables and fruit, and low-fat dairy foods; eliminate sweetened drinks, potatoes, white bread, baked goods and snack foods. 45462/45987 [Am J Clin Nutr, Jul 2007;86:1:107-15] 10/2007 Summary Interview PubMed

Addiction - cocaine, n-acetylcysteine - 50973

N-acetylcysteine (NAC) 1200-2400 mg per day with or without food helped those who had quit cocaine stay away from trying it again and reduced the craving. NAC increases cystine which displaces glutamate in brain cells, bringing back glutamate balance, and reducing cravings and impulsivity. [Am J Addict. 2013 Sep-Oct;22(5):443-52. 50973 (10/2015)] Interview PubMed

Addiction - dhea - 45738

DHEA 25-50 mg/d in chronic opioid users may be beneficial. J Pain. Dec 2006 7 12 901-7 45738 5/2007 Interview PubMed

Addiction - dheas - 45738

DHEAS levels in opioid users were low and frequently undetectable. 45738 [J Pain, Dec 2006;7(12):901-7] 5/2007 Interview PubMed

Addiction - n-acetylcysteine - 45645

N-acetylcysteine 600 mg b.i.d. - 1200 mg t.i.d. has reduced cocaine and heroin craving. Am J Psychiatry 2007 164 7 1115-7 45645 [Am j Psychiatry, 2007;164(7):1115-7] 11/2007 Summary Interview PubMed

Adenomatous Polyps - eicosapentaenoic acid - 47914

Eicosapentaenoic acid - one gram twice daily with meals of a 99% eicosapentaenoic acid (EPA) supplement.
[Gut, 2010 March 26; [Epub ahead of print]. 47914 (6/2010)] Summary Interview PubMed

Adrenoleukodystrophy (ALD) - methyl vitamin B12 - 24043

Methyl vitamin B12 1500 mcg/d normalized circadian rhythms. Brain and Development 1995 17 428-431 24043 1995 Summary Interview PubMed

Adult Respiratory Distress Syndrome (ARDS) - ginger - 47775

Ginger extract - 120 mg in divided doses with three meals during tube feeding. [J Crit Care, 2010 Feb 9; [Epub ahead of print]. 47775 (4/2010)] Summary Interview PubMed

Age Related Macular Degeneration (AMD) - endothelial dysfunction, lifestyle - 51070

Age-related macular degeneration (AMD) is a result of lifestyle factors that result in disordered functioning of endothelium (ED) in the vessels supplying the affected ocular structures with blood (choroidalneovascularization [CNV]). AMD is a local manifestation of systemic vascular disease. Treatment includes lifestyle modification by AMD-patients: (1) smoking cessation; (2) reduction of body weight (slimming); (3) regular, appropriate physical activity; (4) prescribing a low glycemic, phytochemically rich diet which includes: (a) flavonoids, (b) polyphenols (c) omega-3 long-chain polyunsaturated fatty acids (docosahexaenoic acid and eicosapentaenoic acid); (d) carotenoids (lutein and zeaxanthin); (e) management of dietary glycemic index (GI); (5) caloric restriction (CR); (6) elimination/discontinuance of the stressful lifestyle. Orv Hetil. 2015 Jul 12;156(28):1128-32. 51070 (12/2015) Interview PubMed

Age Related Macular Degeneration - acetyl-carnitine - 43591/43893

Acetyl-carnitine 100 mg/d. Ophthalmologica May-June 2005 219 3 154-66 43591/43893 11/2005 Summary Interview PubMed

Age Related Macular Degeneration - cardiovascular disease, infection, zinc - 50683

Zinc at 45 mg of elemental zinc daily as acetate or gluconate administered in the post absorptive state (2-3 h after dinner) has been shown to reduce cardiovascular risk. Zinc has been shown to be deficient in 30% of some elderly populations and has shown therapeutic value in slowing age-related macular degeneration, cardiovascular risk markers and infections. Doses of elemental zinc of 50 mg or more should be taken with 1 mg of copper. Serum levels of zinc are the most clinically efficient way to assess for zinc status. [J Trace Elem Med Biol. 2014 Oct;28(4):364-371. 50683 (2/2015)] Interview PubMed

Age Related Macular Degeneration - carotenoid - 45466

Carotenoid 21.8 mg/d (14.9 mg of meso-zeaxanthin, 5.5 mg of lutein and 1.4 mg of zeaxanthin) increased macular pigment optical density. Nutr Metab (Lond), 2007 4 12 45466 9/2007 Summary Interview PubMed

Age Related Macular Degeneration - coenzyme Q10 - 43591/43893

Coenzyme Q10 10 mg/d (along with acetyl-l-carnitine 100 mg and omega-3 fatty acid 500 mg from fish oil). Ophthalmologica May-Jun 2005 219 3 154-66 43591/43893 11/2005 Summary Interview PubMed

Age Related Macular Degeneration - diet - 44227/45481/45762/44790

Diet - Low glycemic index (low in refined carbohydrates), high in fruit and vegetables reduces risk; high glycemic index diet increases risk. Am J Clin Nutr, Apr 2006 83 4 880-886 44227;45481;45762/44790 7/2006 Summary Interview PubMed

Age Related Macular Degeneration - egg yolk - 47554

Egg yolks 2-4/d increased macular pigment optical density (MPOD). [Am J Clin Nutr, 2009; 90(5): 1272-9. 47554 (12/2009)] Summary Interview PubMed

Age Related Macular Degeneration - eggs - 44828

Eggs - 6 per week for 12 weeks increased zeaxanthin and macular pigment optical density (MPOD). J Nutr, 2006 136 10 2568-73 44828 5/2007 Summary Interview PubMed

Age Related Macular Degeneration - lutein - 26771

Lutein supplementation can increase serum levels by 15 times and in macular pigment by 40%. Lutein converts to zeaxanthin in the retina. Advances in Pharmacology 1997 38 38 537-553 26771 1997 Summary Interview PubMed

Age Related Macular Degeneration - omega-3 fatty acids - 43591/43893

Omega-3 fatty acids 500mg/d. (750 mg fish oil with n-3 concentration of 60%). Ophthalmologica May-Jun 2005 219 3 154-66 43591/43893 11/2005 Summary Interview PubMed

Aggression - tryptophan - 21426

Amino acid mixtures given to aggressive healthy subjects in the ratio of human breast milk, with or without 10.6 g of tryptophan, showed with tryptophan reduced aggressiveness; without tryptophan increased aggressiveness. Arch Gen Psych December 1994 51 1004-1005 21426 1995 Summary Interview PubMed

Aging - (male) propionyl-L-carnitine - 42609

Carnitine - propionyl-L-carnitine 2 g/day + acetyl-L-carnitine 2 g/day produced a significant increase in nocturnal penile tumescence (NPT), sexual function, level of the mood and resistance to muscular exercise greater than testosterone replacement. Urology 2004 63 4 641-646 42609 02/2005 Summary Interview PubMed

Aging - (skin) niacinamide - 43579/43537

Niacinamide 5% topical (glycerol, panthenol, vitamin E, vehicle pH 6). Dermatol Surg Jul 2005 31 7 Pt 2 860-5; discussion 865 43579 / 43537 9/2005 Summary Interview PubMed

Aging - amino acids - 42895/43681

Amino acids mixture 12 gm/d. (L-leucine 3.8, L-lysine 2, L-isoleucine 1.9, L-valine 1.9, L-threonine 1.1, L-cystine 0.4, L-histidine 0.4, L-phenylalanine 0.3, L-methionine 0.2, L-tyrosine 0.1, and L-tryptophan 0.1.) Gerontology Sep-Oct 2005 51 5 302-8 42895/43681 11/2005 Summary Interview PubMed

Aging - b vitamins - 40953

B vitamins - 30% of 168 women 60-70 years of age did not reach the RDA for thiamine and more than 80% failed to meet the RDA for folate equivalents. Am J Clin Nutr 2003 78 765-772 40953 2003 Summary Interview PubMed

Aging - b vitamins - 40953

B vitamins - 1/3 of 168 women 60-70 years of age had indexes of thiamine and pyridoxine, and serum cobalamin indicating insufficient status; tHcy was elevated in 17.4 % (suggesting insufficient folate, vitamin B12 and/or vitamin B6); MMA was elevated in 9.6 % of the women (inadequate vitamin B12); subjects in the lowest quartile of serum folate had a 23 % higher tHcy concentration than subjects in the highest quartile. Am J Clin Nutr 2003 78 765-772 40953 2003 Summary Interview PubMed

Aging - cardiovascular diseaes, macular degeneration, zinc - 50683

Zinc at 45 mg of elemental zinc daily as acetate or gluconate administered in the post absorptive state (2-3 h after dinner) has been shown to reduce cardiovascular risk. Zinc has been shown to be deficient in 30% of some elderly populations and has shown therapeutic value in slowing age-related macular degeneration, cardiovascular risk markers and infections. Doses of elemental zinc of 50 mg or more should be taken with 1 mg of copper. Serum levels of zinc are the most clinically efficient way to assess for zinc status. [J Trace Elem Med Biol. 2014 Oct;28(4):364-371. 50683 (2/2015)] Interview PubMed

Aging - cardiovascular fitness - 33860

Cardiovascular fitness maintenance (aging male) minimum 4 x per week for 1 hour: aerobic exercise - maintain a respiratory rate of 25-30 per minute or be able to carry on a conversation. Heat rate monitoring Karvonen formulae: Age 70 = 20-21 HR per 10 seconds; age 60 = 21-22 HR per 10 seconds, age 50 = 22-24 HR per 10 seconds, age 40 = 23-25 HR per 10 seconds and age 30 = 24-26 HR per 10 seconds. Age and Ageing 1999 28 531-536 33860 2000 Summary Interview PubMed

Aging - creatine - 45920

Creatine 3 to 25gms/d with water or juice 1 hour before and immediately after working out (training days only). Cycle creatine supplementing 4-6 weeks on and then 4-6 weeks off. J Nutr Health Aging Mar-Apr 2007 11 2 185-8 45920 10/2007 Summary Interview PubMed

Aging - creatine monohydrate - 45660

Creatine monohydrate 5 gm q.i.d. in elderly benefitted verbal and visual short term memory and long term memory (with or away from meals). Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 2007 14 5 517-28 45660 1/2008 Summary Interview PubMed

Aging - glutathione - 21961

Glutathione - higher levels are associated with longevity. Cruciferous vegetable family including cauliflower, broccoli, cabbage, kale, brussels sprouts, etc. contain glutathione; and N-acetylcysteine, pine bark extract (pycnogenol), melatonin, bilberry grape extract and turmeric enhance glutathione. J Clin Epidemiol 1994 47 9 1021-1026 21961 1996 Summary Interview PubMed

Aging - green tea - 50050

Green tea consumption in ascending order of intake 1 to 5 or more cups per day is associated with a reduction in functional disability (cognitive function, depression, psychological distress, stroke) and healthy life expectancy, in a dose dependent fashion. [Am J Clin Nutr. 2012 March;95(3):732-739. 50050 (5/2012)] Interview PubMed

Aging - homocysteine - 20547

Homocysteine elevation - maybe 5 to 10% of elderly individuals may be deficient in vitamin B12 without neurologic damage, megaloblastic anemia or a high MCV. Am J Clin Nutr 1994 60 2-11 20547 1996 Summary Interview PubMed

Aging - lifestyle - 24217

Lifestyle Measures 1) moderate amount of exercise; 2) keeping dietary fat below 20% of the caloric intake; 3) antioxidant supplements, e.g. 400 IU of vitamin E per day, 500 mg of vitamin C 3 times a day, 25,000 IU of beta-carotene every other day, 30 mg of coenzyme Q10 per day and 100 mcg of selenium daily in yeast tablets or as the selenite. Moderation in smoking and drinking and restrict caloric intake to an acceptable level. Age 1995 18 51-62 24217 1996 Summary Interview

Aging - melatonin - 24221

Melatonin may have antiaging properties. Aging and Clinical Experimental Research 1995 7 338-339 24221 1998 Summary Interview PubMed

Aging - melatonin - 44135

Melatonin < 3 mg/d Endocrine Jul 2005 27 2 201-12 44135 12/2005 Summary Interview PubMed

Aging - methylmalonic acid - 20547

Methylmalonic acid elevation - maybe 5 to 10% of elderly individuals may be vitamin B12 deficient with neurologic damage, without megaloblastic anemia or a high MCV. Am J Clin Nutr 1994 60 2-11 20547 1996 Summary Interview PubMed

Aging - multivitamin/mineral - 27904

Multivitamin/mineral supplement no more than 2-3 times the RDAs. Am J Clin Nutr 1997 66 478S-84S 27904 1997 Summary Interview PubMed

Aging - pet therapy/ownership - 23982

Pet therapy/ownership can lower blood pressure and has showed improvement in self-care functioning, irritable behavior, and withdrawn behavior, especially in elderly patients. Am J Occupat Therapy Jan 1996 50 1 47-51 23982 1997 Summary Interview PubMed

Aging - selenium - 43794/44052

Selenium 100 mcg/d. Clin Chem Nov 2005 51 11 2117-23 43794/44052 3/2006 Summary Interview PubMed

Aging - vitamin b12 - 33146

Vitamin B12 - 69 of 266 subjects > 70 years of age had serum B12 <300 pmol/L and serum methylmalonic acid (MMA) ≥0.37 µmol/L or serum total homocysteine (tHcy) ≥15 µmol/L. 1 mg cyanocobalamin I.M. injections initially followed by 2 mg orally normalized MMA in 13 of 15 subjects. Additional folic acid 5 mg/d normalized tHcy in all but 1. J Intern Med 1999 246 317-324 33146 1999 Summary Interview PubMed

Aging - vitamin d - 22863

Vitamin D deficiency is common in the elderly. Risk factors include lack of sunlight, medications, malabsorption and surgery. Vitamin D deficiency has been associated with bone loss, increased risk of fractures, muscle weakness, pain and impairment of immunologic function. J Am Geriatric Soc 1995 43 822-828 22863 1996 Summary Interview PubMed

Aging - vitamin d - 22863

Vitamin D - 30 minutes of sunlight 2 to 3 times a week; vitamin D2 100,000 IU every 3 months or vitamin D3 800-1600 I.U./d. J Am Geriatric Soc 1995 43 822-828 22863 1996 Summary Interview PubMed

Aging - zinc - 23041

Zinc deficiency in the elderly can lead to reduced immune function and increased infections. Aging and Clinical and Experimental Research 1995 7 2 75-76 23041 1995 Summary Interview PubMed

Aging - zinc gluconate - 45884

Zinc gluconate (45 mg elemental zinc) daily in a single or divided dose away from meals reduced infections, tumor necrosis factor alpha, oxidative stress markers. Am J Clin Nutr Mar 2007 85 3 837-44 45884 8/2007 Summary Interview PubMed

AIDS/HIV - b vitamins - 25119

B vitamins - B1 at 5 to 140 x RDA (median = 8 x RDA); B2 at 5 to 118 x RDA (median = 6.7 x RDA); B6 at 2 to 100 x RDA (median = 3 x RDA); B3 (niacin) at 3.5 to 20 x RDA (median = 5 x RDA), total intake (food and supplements combined) associated with improved survival. Am J Epidemiol 1996 143 12 1244-1256 25119 1996 Summary Interview PubMed

AIDS/HIV - beta-carotene - 25243

Beta-carotene 60 mg/d (mild increase in GPX activity). Am J Clin Nutr 1996 64 101-107 25243 1996 Summary Interview PubMed

AIDS/HIV - curcumin - 25538

Curcumin 1-2 tablets initially tapering up to two 500 mg tablets t.i.d. with meals. J National Med Assoc June 1996 88 6 333 25538 1996 Summary Interview PubMed

AIDS/HIV - fish oil - 24119/24112

Fish oil - Five food bars per day containing 2 gm fish oil per bar. J Parent Ent Nutr 1996 20 1 43-49 24119/24112 1996 Summary Interview PubMed

AIDS/HIV - multivitamin/mineral - 25119

Multivitamin/mineral (high potency) with B vitamins 3-5 times the RDA. Am J Epidemiol 1996 143 12 1244-1256 25119 1996 Summary Interview PubMed

AIDS/HIV - myopathy - 43916

Myopathy (skeletal) induced by nucleoside reverse transcriptase inhibitor (NRTI) therapy - coenzyme Q10 300 mg/d reversed myopathy with concurrent zidovudine use. Int J STD AIDS 2005 16 12 827-9 43916 3/2006 Summary Interview PubMed

AIDS/HIV - selenium - 20378

Selenium (yeast bound) 200-300 IU/d (under medical supervision 800 mcg/d). Chemico-Biological Interactions 1994 91 188-205 20378 1996 Summary Interview PubMed

AIDS/HIV - selenium - 25243

Selenium (selenomethionine) 100 mcg/d (increase in GPX activity; decrease in beta-2 microglobulin). Am J Clin Nutr 1996 64 101-107 25243 1996 Summary Interview PubMed

AIDS/HIV - selenium - 27325

Selenium (sodium selenite) 200-400 mcg/d (increase in GPX activity). Bio Trace Element Res 1997 56 31-41 27325 1997 Summary Interview PubMed

AIDS/HIV - vitamin b12 - 27086

Vitamin B12 - low serum levels were associated with progression to AIDs. J Nutr 1997 127 345-351 27086 1997 Summary Interview PubMed

Akathisia (Neuroleptic-Induced) - vitamin B6 - 42386

Vitamin B6 600 mg b.i.d.. [J Clin Psychiatry, November 2004, 65;11:1550-1554 42386 (01/2005)] Summary Interview PubMed

Alcoholism - benfotiamine, depression, vitamin b1 - 50892

Benfotiamine is a thiamine (B1) given at 600 mg taken in one dose or divided doses with or without meals in males with alcohol dependence reduced psychiatric symptoms including depression. Drug Alcohol Depend. 2015 Jul 1;152:257-63. 50892 (8/2015) Interview PubMed

Alcoholism - nicotinamide - 28598/28599

Nicotinamide 1.25 gm with meals and wine intake reduced the effect of alcohol on lactate/pyruvate ratio, prevented the reduction of albumin and fibrinogen secretory rates therefore counteracting the acute hepatotoxic effect of ethanol by ameliorating the redox state. J Nutr 1997 127 2199-2204 28598/28599 1998 Summary Interview PubMed

Alexithymia - vitamin d - 50500

Alexithymia is inversely associated with vitamin D levels and higher rates of alexithymia are associated with mental disorders (autistic spectrum disorder (ASD), depression and eating disorders) and neurodegenerative disorders (Parkinson’s disease, Alzheimer’s disease, multiple sclerosis). The prevalence of alexithymia in the general population is around 10%, however, more than 50% of patients with autism spectrum conditions show higher degree of alexithymia. [Nutr Neurosci, 2014 Mar 4. [Epub ahead of print] 50500 (10/2014)] Interview PubMed

Allergic Rhinitus - trans fats - 32340

Trans fats increase risk. [The Lancet, June 12, 1999;353:2040-2041. 32340 (1999) ] Summary Interview PubMed

Allergy (atopic) - lactobacillus - 26730

Allergy (atopic) Lactobacillus GG 5 x 108 CFU/d in infants. J Allergy Clin Immunol 1997 99 179-185 26730 1997 Summary Interview PubMed

Allergy (atopic) - omega-3 fatty acids - 32892

Omega-3 fatty acids (eicosapentaenoic acid (20:5 ω-3), docosahexaenoic acid (22:6 ω-3) ) reduce atopic sensitization while omega-6 fatty acid excess (arachidonic acid (AA; 20:4 ω-6)) increase inflammatory mediators and increase atopic expression; approximate 1:1 omega-3/omega-6 ratio is optimal. Ann Med 1999 31 282-287 32892 1999 Summary Interview PubMed

Allergy (atopic) - trans fats - 32340

Trans fats increase risk. [The Lancet, June 12, 1999;353:2040-2041 32340 (1999)] Summary Interview PubMed

Allergy (childhood) - common cold - 28908

Common cold symptoms - possibly mold allergy; reduce allergy symptoms by reducing humidity in house; clean house regularly; look for stains or wet surfaces; teach children not to eat in the bedroom, not to leave the TV in the bedroom, and not to lie on carpet; clean the carpet regularly; maintain good circulation of the air throughout the house; and open the windows when weather permits. [Clinical Pediatrics, December, 1997;695-699 28908 (1998)] Summary Interview PubMed

Allergy (childhood) - constipation/cow’s milk - 21598

Constipation (allergic) due to T-cell reaction to cow’s milk protein. Total elimination diet trial. J Pediatr January 1995 126 34-39 21598 1995 Summary Interview PubMed

Allergy (childhood) - constipation/cow’s milk - 38427 / 37932 / 38145

Constipation (allergic) due to T-cell reaction to cow’s milk protein. Total elimination diet trial. Clin Pediatr July 2001 399-402 38427;37932/ 38145 2002 Summary Interview PubMed

Allergy (childhood) - diet - 45039

Diet - A high intake of margarine and vegetable oils during pregnancy increases the risk for eczema in the offspring, while high fish intake decreases the risk. Infants born to mothers who ate a lot of celery, citrus fruit, raw sweet pepper and deep-frying vegetable fat during pregnancy were at increased risk for allergic sensitization. [Am J Clin Nutr, 2007;85(2)530-7 (45039) 5/2007 Summary Interview PubMed

Allergy (childhood) - infection - 33409

Infection - early is protective. Clin Exp All 1999 29 1304-1308 33409 1999 Summary Interview PubMed

Allergy (childhood) - lactobacillus reuteri - 45163

Lactobacillus reuteri ATCC 55730 (LRA) 1 x 108 bacteria/d in a single daily dose orally [to mothers from 36 weeks gestation to delivery and the child from birth through 12 months] reduced IgE sensitization (and IgE eczema) (in oil drops in infants). J Allergy Clin Immunol March 7 2007 [Epub ahead of print] 45163 8/2007 Summary Interview PubMed

Allergy (childhood) - omega-3/omega-6 - 45163

Omega-3/omega-6 balance reduces risk. Clin Exp Allergy 1999 29 1304-1308 c 1999 Summary Interview PubMed

Allergy (childhood) - siblings - 33409

Siblings increase early infections which may be protective. Clin Exp All 1999 29 1304-1308 33409 1999 Summary Interview PubMed

Allergy (food) - prevention - 33918

Prevention - 1) Rotate the foods in your diet; 2) Avoid or reduce the intake of processed foods, especially foods high in sugar; 3) Make as much of your diet organic as possible; 4) Do not drink alcoholic beverages before eating; 5) Eat a balanced diet including grains, fresh fruit and vegetables, fresh meats, etc; 6) Chew your food well; and 7) Do not drink water during a meal. It dilutes your digestive juices. "Immunology of Food Allergy," Marinkovich, Vincent A, Personal Monograph 1999 1-7 33918 2000 Summary Interview

Allergy (food) - constipation - 21598

Constipation in children (cow’s milk protein, eggs, tomatoes, fish and citrus fruit, etc.). J Pediatr January 1995 126 34-39 21598 1995 Summary Interview PubMed

Allergy (food) - constipation - 38427 / 37932 / 38145

Allergy (food) Constipation in children (cow’s milk protein, eggs, tomatoes, fish and citrus fruit, etc.). Clin Pediatr July 2001 399-402 38427 / 37932 / 38145 2002 Summary Interview PubMed

Allergy (food) - Igg mast testing - 33918

IgG MAST testing - food and mold plate has foods and molds attached covalently to cellulose threads and are contained in a single pipette chamber. "Immunology of Food Allergy," Marinkovich, Vincent A, Personal Monograph, 1999 1-7 33918 2000 Summary Interview

Allergy (food) - prevention, treatment - 24067

Prevention and Treatment - Alka Seltzer (gold) can prevent food reactions if taken before the intake of food - works about 2/3 of time, or, when reacting to food take Alka Seltzer (gold) which relieves symptoms in about 20 minutes. J Learning Disabilities 1979 12 42-50 24067 1996 Summary Interview PubMed

Allergy (food) - prevention, treatment - 24068

Prevention and Treatment - Alka Seltzer (gold) can prevent food reactions if taken before the intake of food - works about 2/3 of time, or, when reacting to food take Alka Seltzer (gold) which relieves symptoms in about 20 minutes. J Learning Disabilities 1978 11 56-64 24068 1996 Summary Interview PubMed

Allergy (general) - herbal medications - 32662

Herbal medications (ex. Echinacea). J Asthma 1999 36 1 1-65 32662 1999 Summary Interview PubMed

Allergy (general) - lactobacillus reuteri - 32662

Lactobacillus reuteri ATCC 55730 (LRA) 1 x 108 bacteria/d in a single dose reduced IgE sensitization/IgE eczema (in oil drops in infants). J Allergy Clin Immunol March 7 2007 [Epub ahead of print] c 8/2007 Summary Interview PubMed

Allergy (general) - vitamin e - 36406

Vitamin E in diet 9 mg/d may prevent/reduce IgE allergy. The Lancet Nov. 4 2000 356 1573-1574 36406 2001 Summary Interview PubMed

Allergy (mold) - common cold - 28908

Common cold symptoms - possibly mold allergy; reduce allergy symptoms by reducing humidity in house; clean house regularly; look for stains or wet surfaces; teach children not to eat in the bedroom, not to leave the TV in the bedroom, and not to lie on carpet; clean the carpet regularly; maintain good circulation of the air throughout the house; and open the windows when weather permits. Clinical Pediatrics December 1997 695-699 28908 1998 Summary Interview PubMed

Allergy (wheat) - diet - 43145 / 45167

Diet - delaying introduction of wheat, barley, rye and oats until after 6 months of age was associated with an increased risk of wheat allergy. JAMA May 18 2005 293 19 2343-51 43145/45167 2/2007 Summary Interview PubMed

Alzheimers Disease - curcumin - 47274

Curcumin BCM-95 1 - 4 gm/d with food. [Journal of Clinical Psychopharmacology, 2008;28:110-13. 47274 (7/2009)] Summary Interview PubMed

Alzheimer's Disease - turmeric - 49645

Turmeric 764 mg/day (curcumin 100 mg/day) divided into two doses, after meals, if possible with warm milk to increase absorption (supplied by KANEHIDE BIO Co. LTD). No side effects were noted and there was good compliance. Turmeric may work by preventing the amyloid-β cascade, tau phosphorylation, neuroinflammation, oxidative stress, acetylcholinesterase activity, choline acetyltransferase activity, and a synthesizing enzyme for acetylcholine.

[Ayu, 2012 Oct; 33(4): 499-504. 49645 (6/2013)] Summary Interview PubMed

Alzheimer’s Disease - diet - 34806

Diet after age 60 predominant risk factor. J Alzheimer’s Dis 1999 1 197-201 34806 1999 Summary Interview PubMed

Alzheimer’s Disease - diet - 34806

Diet low in fat and total energy, increased in fruits, vegetables and whole grains reduces the risk of Alzheimer’s disease. J Alzheimer’s Dis 1999 1 197-201 34806 1999 Summary Interview PubMed

Alzheimer’s Disease - diet - 42067

Diet high in total carbohydrate (refined or unrefined) with APOE4 allele (inhibit lipid metabolism similar to a high carbohydrate diet) increases risk. Medical Hypothesis 2004 62 689-700 42067 11/2004 Summary Interview PubMed

Alzheimer’s Disease - dietary pattern - 50334

Dietary pattern that is low-fat, plant-based diet with few processed foods, includes omega-3 fatty acid (e.g., fish oil) supplements, moderate alcohol consumption, no smoking, keeping serum 25-hydroxyvitamin D levels above 30-40 ng/mL (75-100 nmol/L), and exercise on a regular basis. Rice consumption may be protective. [J Alzheimers Dis. 2014;38(3):611-20. 50334 (6/2014)] Interview PubMed

Alzheimer’s Disease - fat - 34806

Fat - high in total fat, saturated fat and cholesterol increase risk. [J Alzheimer’s Dis, 1999;1:197-201. 34806 1999)] J Alzheimer’s Dis 1999 1 197-201 34806 1999 Summary Interview PubMed

Alzheimer’s Disease - faty acids - 42067

Fatty acids - increase the omega 3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Medical Hypothesis 2004 62 689-700 42067 11/2004 Summary Interview PubMed

Alzheimer’s Disease - fish - 34806

Fish consumption reduced risk. J Alzheimer’s Dis 1999 1 197-201 34806 1999 Summary Interview PubMed

Alzheimer’s Disease - folic acid (serum) - 37878

Folic acid (serum) less than 13 nmol/L and vitamin B12 (serum) less than 251 pmol/L increases risk. [Neurology 2001;56:1188-1194 37878 2001] Summary Interview PubMed

Alzheimer’s Disease - genetics - apoe4 allele - 34806

Genetics - APOE4 allele is associated with an increased risk; only 10 % of Alzheimer’s disease is related to genetics. [J Alzheimer’s Dis, 1999;1:197-201 34806 1999] Summary Interview PubMed

Alzheimer’s Disease - ginkgo biloba - 24968

Ginkgo biloba special extract Egb 761® 240 mg/d. Pharmacopsychiat 1996 29 47-56 24968 1996 Summary Interview PubMed

Alzheimer’s Disease - ginkgo biloba - 46792

Ginkgo biloba special extract Egb 761® 240 mg/d. Alzheimer's and Dementia July 2008 4 4 Supplement, T165-T166 46792 11/2008 Summary

Alzheimer’s Disease - homocysteine - 39403

Homocysteine (a functional test for vitamin B12) is inversely related to Alzheimer’s disease/cognitive decline. Folic acid 1 mg/d, vitamin B12 500 mcg/d, vitamin B6 40 mg/d may lower homocysteine levels. Neurology 2002 58 1395-1399 39403 2002 Summary Interview PubMed

Alzheimer’s Disease - melatonin - 34948

Melatonin reduces formation of beta-amyloid. J Applied Nutr 1999 51 1 3-15 34948 2000 Summary Interview

Alzheimer’s Disease - melatonin - 45955

Melatonin 3-6 mg (fast-release) at bedtime may improve cognitive function. J Pineal Res 2007 43 4 404-409 45955 3/2008 Summary Interview PubMed

Alzheimer’s Disease - mitochondrial energy - 34948

Mitochondrial energy production deficit (acetyl-l-carnitine, CoQ10, phosphatidylserine, magnesium enhance mitochondrial ATP production). J Applied Nutr 1999 51 1 3-15 34948 2000 Summary Interview

Alzheimer’s Disease - nadh - 24840

NADH 2 - 5 mg tablets/d. Annals of Clinical and Laboratory Science 1996 26 1 1-9 24840 1996 Summary Interview PubMed
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