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Cancer (breast) - omega-3:6 fatty acids - 22879

Omega-3:omega-6 fatty acids ratio closer to one inhibits tumor growth. [Oncology, 1995; 52:265-271. 22879 (1995)] Summary Interview PubMed

Cancer (breast) - stress - 24277

Stress - severely threatening life events increased the risk of breast cancer by 11.64 times. [BMJ, December 9, 1995;311:1527-1530. 24277 (1996)] Summary Interview PubMed

Cancer (breast) - unsaturated fatty acids - 24884

Diets high in unsaturated fatty acids (olive oil and seed oils) were associated with a decreased risk. [Lancet, May 18, 1996;347:1351-1356. 24884 (1996)] Summary Interview PubMed

Cancer (breast) - vitamin c - 49837

Vitamin C intravenously at 50 grams per session given twice weekly, two days either side of each chemotherapy session showed a dramatic decreased in fatigue, pain, appetite loss, nausea/vomiting and insomnia with increases in physical, emotional, cognitive and social functioning and a doubling of the patient’s ‘global health status’. [N Z Med J, 2014 Jan 24; 127(1388):66-70. 49837 (5/2014)] Summary Interview PubMed

Cancer (breast) - vitamin D - 43736

Vitamin D 25 hydroxy vitamin D levels (plasma) were inversely related to breast cancer; cases had lowest levels. [Cancer Epidemiol Biomarkers Prev. 2005 Aug;14(8):1991-7. 43736 (11/2005)] Summary Interview PubMed

Cancer (breast) - Vitamin D - 43736

Vitamin D 1, 25-dihydroxy vitamin D (highest levels had reduced risk). [Cancer Epidemiol Biomarkers Prev. 2005 Aug;14(8):1991-7. 43736 (11/2005)] Summary Interview PubMed

Cancer (breast) - vitamin d - 51051

Current vitamin D supplementation was associated with a 26 % decrease in postmenopausal breast cancer risk in menopausal hormone therapy (MHT) users but there was no association in MHT nonusers. [Am J Clin Nutr. 2015 Oct;102(4):966-73 51051 (12/2015)] Interview PubMed

Cancer (cachexia) - carnitine - 48628

L-carnitine 1 gram B.I.D. daily after meals.
[J Cachex Sarcopenia Muscle, 2011 March;2(1):37-44. 48628 (6/2011)] Summary Interview PubMed

Cancer (cachexia) - diet - 44453 / 44981

Diet with high polyphenol content (400 mg) plus antioxidant treatment (300 mg/d alpha-lipoic acid + 2.7 g/d carbocysteine lysine salt + 400 mg/d vitamin E + 30,000 IU/d vitamin A + 500 mg/d vitamin C), and pharmaconutritional support enriched with 2 cans per day (n-3)-PUFA (eicosapentaenoic acid and docosahexaenoic acid), 500 mg/d medroxyprogesterone acetate, and 200 mg/d selective cyclooxygenase-2 inhibitor celecoxib. [Cancer Epidemiol Biomarkers Prev, 2006 May;15 (5):1030-4. 44453/44981 (6/2006)] Summary Interview PubMed

Cancer (chemotherapy) - acetyl-l-carnitine, chemotherapy-induced - 49654

Acetyl-L-carnitine (ALC) at 3,000 mg per day in 409 women with breast cancer undergoing adjuvant taxane-based chemotherapy increased chemotherapy-induced neuropathy (CIPN). [J Clin Oncol, 2013 Jun 3; [Epub ahead of print]. 49654 (7/2013)] Summary Interview PubMed

Cancer (chemotherapy) - Antioxidants

Antioxidants are generally safe and beneficial given at the same time as chemotherapy and started 2 weeks prior to therapy (exceptions are the sulfhydryl antioxidants N-acetyl cysteine, alpha-lipoic acid and glutathione which may interfere with the activity of alkylating agents and platinum coordination complexes; selenium may interfere with platinum coordination complexes; flavonoids, polyphenols and St. John’s Wort may increase chemotherapeutic drug metabolism). [Nutr Cancer, 2000;37(1):1-18. 36236/35744 (2001)] Summary Interview PubMed

Cancer (chemotherapy) - Selenium

Selenium (as kappa-selenocarrageenan) 4000 mcg/d 4 days before and 4 days after I.V. cisplatin significantly reduced nephrotoxicity and bone marrow suppression induced by cisplatin-containing chemotherapy. [Biol Trace Element Res, 1997;56:331-342. 27618 (1997)] Summary Interview PubMed

Cancer (chemotherapy) - Vitamin E

Vitamin E (alpha tocopherol) 100 mg (25 IU/ kg/day) b.i.d. applied topically, or chewed, swished and swallowed, improved uncomplicated mucositis in chemotherapy treated pediatric cancer patients. Vitamin E 100 mg (25 IU/ kg/day) b.i.d. P.O. after meals may prevent mucositis. [J Clin Pediatr Dent, 2007; 31(3):167-70. 45438 (10/2008)] Summary PubMed

Cancer (colorectal) - butyrate, carbohydrate, glycemic index, insulin, starch - 50959

Carbohydrates – a high intake of high glycemic index (GI) carbohydrates increase colorectal cancer risk while a high intake of low GI carbohydrates reduce colorectal cancer risk. High GI carbohydrates create an excessive increase in blood glucose and insulin. Insulin stimulates cell proliferation by direct activation of insulin/insulin-like growth factor (IGF) receptors, or via inhibition of IGF binding proteins, which may result in increased levels of bioavailable IGF-1, which plays an important role in the etiology of colon cancer. A high GI diet is low in resistant starch and resistant starch has been associated with reduced postprandial insulin levels. Resistant starch is fermented by the large intestine flora resulting in increased butyrate levels which play an important role in maintaining intestinal homeostasis and appear to induce the selective apoptosis of colon cancer cells. [Int J Cancer. 2015 Jun 15;136(12):2923-31. 50959 (11/2015)] Interview PubMed

Cancer (colorectal) - Diet

Diet - increasing risk with increasing intake of bread and cereal dishes, potatoes, cakes and desserts and refined sugar. Intakes of fish, raw and cooked vegetables, and fruit other than citrus fruit showed an inverse risk. Consumption of eggs and meat (white, red or processed meats) had no effect. [Internat J Cancer, 1997;72:56-61. 27716 (1997)] Summary Interview PubMed

Cancer (colorectal) - Diet - 2

Diet - reduce risk with high intake of fruits, grains, nuts and vegetables. [JNCI, July 16, 1997;89(14):10006-10014. 27860 (1997)] Summary Interview PubMed

Cancer (colorectal) - Diet - 3

Diet - significant associations were observed for refined grain (OR=1.32 for an increase of one serving per day), and red meat (OR=1.54), pork and processed meat (OR=1.27), alcohol (OR=1.28), and significant protections for whole grain (OR=0.85), raw (OR=0.85) and cooked vegetables (OR=0.69), citrus (OR=0.86) and other fruits (OR=0.85), and for coffee (OR=0.73). Garlic was also protective (OR=0.32 for the highest tertile of intake). [Br J Can 1999;79(7/8): 1283-1287. 32144 (1999)] Summary Interview PubMed

Cancer (colorectal) - Folic acid

Folic acid 1 mg/d x 1 year reduced by 50% the recurrence of precancerous colon polyps. [Proc Assoc Am Physicians, 1995;107:218-227. 24343 (1996)] Summary Interview PubMed

Cancer (colorectal) - Folic acid - 2

Folic acid 10 mg/d x 6 months significantly reduced biochemical alterations thought to precede cancer in the colonic lining. [Proc Assoc Am Physicians, 1995;107:218-227. 24343 (1996)] Summary Interview PubMed

Cancer (colorectal) - Tea

Tea -10 cups Japanese green tea containing 1 gm tea polyphenols reduced risk. [Mutation Research, 1998;402:307-310. 30769/30770 (1999)] Summary Interview PubMed

Cancer (colorectal) - Vitamin D

Vitamin D 2000 IU/d increased serum 25 hydroxyvitamin D to 34 ng/ml and reduced colorectal cancer rate by 50%. [Am J Prev Med, 2007 Mar;32 (3):210-6. 45061/45894 (7/2007)] Summary Interview PubMed

Cancer (colorectal) - Vitamin D - 2

Vitamin D - incidence rates of cancers of the breast, colon and ovary are much lower in sunny places in the world; cancers of the kidney and endometrium are lower in sunny regions; inverse associations of serum 25(OH)D with cancers of the breast and ovary; and study showing vitamin D levels reduce colon cancer risk. [J Steroid Biochem Molec Biol, 2007;103(3-5):708-711. 45265 (2/2008)] Summary Interview PubMed

Cancer (colorectal) - Vitamin E

Vitamin E (alpha-tocopherol and gamma-tocopherol) 50 mg/d. [JNCI, July 16, 1997;89(14):10006-10014. 27860 (1997)] Summary Interview PubMed

Cancer (colorectal) - Wheat bran

Wheat bran is slowly fermented all along the colon. [Clinical Investigation, 1994;72:742-748. 21315 (1996)] Summary Interview PubMed

Cancer (colorectal) - Whole grain

Whole grain intake is inversely related to colon cancer risk. [Br J Can 1999;79 (7/8): 1283-1287. 32144 (1999)] Summary Interview PubMed

Cancer (esoohageal) - calcium, fruit, polycyclic aromatic hydrocarbons, vegetable - 50936

Calcium dietary intake was inversely associated with esophageal cancer. Fruit and vegetable consumption reduces risk while exposure to polycyclic aromatic hydrocarbons (PAH) increase risk. [Am J Clin Nutr. 2015 Jul;102(1):102-8. 50936 (9/2015)] Interview PubMed

Cancer (general) - Antioxidant therapy

Antioxidant therapy: 1) alpha lipoic acid 200 mg/day orally; N-acetylcysteine 1800 mg/day i.v. or carboxycysteine-lysine salt 2.7 g/day orally; 2) amifostine 375 mg/day i.v.; 3) reduced glutathione 600 mg/day i.v.; 4) and a combination of vitamin A 30,000 IU/day orally, vitamin E 70 mg/day orally and vitamin C 500 mg/day orally. Each antioxidant treatment was administered for 10 consecutive days. All treatments reduced oxidative stress and markers of inflammation. [J Environ Pathol Toxicol Oncol, 2003;22(1):17-28. 42913 (4/2005)] Summary Interview PubMed

Cancer (general) - Antioxidant therapy - 2

Antioxidant therapy: polyphenol-rich diet containing at least 400 mg/day (1-2 glasses of red wine + plus fresh fruit and vegetables such as apples, oranges, onions + green tea); alpha lipoic acid 200-300 mg/day; carbocysteine lysine salt 2.7 g/day (1 sachets); and a combination of vitamin A 30,000 IU/day, vitamin E 70 mg/day and vitamin C 500 mg/day orally. The best antioxidant regimen to give to an inpatient is the same as for home patients plus reduced glutathione 600 mg/day I.V.. [J Environ Pathol Toxicol Oncol, 2003;22(1):17-28. 42913 (4/2005)] Summary Interview PubMed

Cancer (general) - Apheresis

Apheresis (whole blood filtration) reduces tumor necrosis factor receptors which inhibit tumor necrosis factor’s ability to destroy the cancer. [Therapeutic Apheresis, 1999;3(1):40-49. 36666 (2001)] Summary Interview PubMed

Cancer (general) - artificial light at night (alan), led, melatonin - 50792

Artificial light at night (ALAN), mainly of short wavelength as LED, suppresses pineal melatonin production, and epigenetic changes as global DNA modification (hypo-methylation), may increase the risk to cancer, especially breast cancer and prostate cancer. [Philos Trans R Soc Lond B Biol Sci. 2015 May 5;370(1667). 50792 (6/2015)] Interview PubMed

Cancer (general) - Carnitine

Carnitine 6 gm/d. [Nutrition, 2006; 22(2): 136-45. 44062 (3/2006)] Summary Interview PubMed

Cancer (general) - Cholesterol

Cholesterol lowering (fibrates and statins) causes cancer in rodent models. [JAMA, January 3, 1996;275(1):55-60. 24024/24021 (1996)] Summary Interview PubMed

Cancer (general) - Diet

Diet during chemotherapy - a polyphenol-rich diet containing at least 400 mg/day; 1-2 glasses of red wine + plus fresh fruit and vegetables such as apples, oranges, onions + green tea. [J Environ Pathol Toxicol Oncol, 2003;22(1):17-28. 42913 (4/2005)] Summary Interview PubMed

Cancer (general) - Dietary prevention

Dietary prevention by consuming lots of green leafy vegetables (vitamin E); milk and dairy (CLA); fish (omega-3 fatty acids); tumeric and ginger used frequently in cooking; hot green or black tea with shreds of ginger. [Prostaglandins, Leukotrienes and Essential Fatty acids, 1996;54:3-16. 24636 (1996)] Summary Interview PubMed

Cancer (general) - Glutamine

Glutamine 20-30 gm/d P.O. or I.V. for catabolic state. [J Nutr, 2001:2569S-2577S. 38827 (2003)] Summary Interview PubMed

Cancer (general) - Green tea

Green tea (10 Japanese cups of green tea per day = 1 gm tea polyphenols) delayed cancer onset by 7.3 years among females and 3.2 years among males, compared with patients who consumed less than three cups per day. [Mutation Research, 1998;402:307-310. 30769/30770 (1999)] Summary Interview PubMed

Cancer (general) - Melatonin

Melatonin 10-40 mg 1 hour before bed. [J Pineal Res, 2005 Nov;39(4):360-6. 44561 (4/2006)] Summary Interview PubMed

Cancer (general) - Melatonin - 2

Melatonin 10-40 mg 1 hour before bed. [Support Care Cancer, 2002;10:110-116. 39523 (2002)] Summary Interview PubMed

Cancer (general) - Melatonin - 3

Melatonin 10-50 mg/d. [Am J Hospice Palliative Med, July/August 2005;22(4):295-305. 43503 (9/2005)] Summary Interview PubMed

Cancer (general) - Melatonin - 4

Melatonin - more data on benefit in cancer treatment than prevention - both promising. [Cancer Res, 2006 Oct 15;66(20):9789-93. 45406 (2/2007)] Summary Interview PubMed

Cancer (general) - metabolic therapy, hydroxycitrate, lipoic acid, naltrexone -

Metabolic Therapy - A combination of lipoic acid at 600 mg I.V. (Thioctacid); hydroxycitrate 500 mg t.i.d. (Solgar); and low-dose Naltrexone at 5 mg (Revia) at bedtime in 10 patients with chemoresistant advanced metastatic cancer slowed cancer growth in a wide range of different tumor types with minimal toxicity. [Anticancer Res. 2014 Feb;34(2):973-80. 50387 (7/2014)] Interview PubMed

Cancer (general) - N-acetylcysteine

N-acetylcysteine 600 mg/d may prevent secondary tumors in treated cancer patients. [Eur J Cancer, 1995; 31A(6):921-923. 23078 (1995) Summary Interview PubMed

Cancer (general) - Selenium

Selenium 200 mcg/d reduced cancer mortality by 50%, with mortality from cancers of the prostate and lung being particularly reduced. [Br Med J, February 8, 1997;314:387-388. 26998 (1997)] Summary Interview PubMed

Cancer (general) - Sunlight

Sunlight - inverse relation between solar UVB and 17 types of internal cancers plus melanoma, and a direct relationship between solar UVB and squamous cell carcinoma (SCC), and a direct relationship between solar UVA (320-400 nm) and basal cell carcinoma (BCC) and melanoma. [J Natl Med Assoc, 2006 Mar;98(3):357-64. 44662 (4/2006)] Summary Interview PubMed

Cancer (general) - Tocotrienols

Tocotrienols 200 mg b.i.d. with meals may be of benefit. [Mol Aspects Med. 2007 Oct-Dec;28(5-6):692-728. Epub 2007 Mar 27. 46221 (6/2008)] Summary Interview PubMed

Cancer (general) - vegetarian diet - 49219

Vegetarians have lower: all cause mortality; ischemic heart disease (IHD); mortality from circulatory diseases; mortality from cerebrovascular disease; significantly lower cancer incidence than nonvegetarians. Vegetarians have reduced cardiovascular risk factors compared with omnivores including: decreased body mass index; waist to hip ratio; blood pressure; plasma total cholesterol (TC); triglycerides; LDL-C levels; serum lipoprotein(a); plasma factor VII activity; the ratio of TC/HDL-C, LDL-C/HDL-C and TAG/HDL-C, and serum ferritin levels. [Ann Nutr Metab, 2012 Jun 1;60(4):233-240. 49219 (7/2012)] Summary Interview PubMed

Cancer (general) - Vitamin B1

Vitamin B1 (thiamine) and transketolase play a central role in the RNA/DNA synthesis, which determines cell proliferation rate and the rapid progression of tumors. Thiamin supplementation and fortification may INCREASE cancer risk. [Anticancer Res, 2000;20:2245-2248. 35864 (2000)] Summary Interview PubMed

Cancer (general) - Vitamin C

Vitamin C I.V. to achieve a plasma level of ≥ 400 mg/dl (usually 60-100 gms per infusion; patient must be G6PD negative) prior to the first dose of chemotherapy along with oral doses of vitamin E 200 IU/d and vitamin C 3,000-9,000 mg/d. [J Am Coll Nutr, 2003;22(2): 118-123. 40433 (2003)] Summary Interview PubMed

Cancer (general) - vitamin c, inflammation - 50314

Vitamin C (15 g -75 g intravenously) at .5-1 grams per minute, after the first IVC of 15 grams, followed by either 25 or 50 grams of IVC dose twice a week (5-18 treatments) until post IVC plasma levels were reached (350- 400 mg/dL) reduced inflammation markers (C-reactive protein and inflammatory cytokines) in cancer patients. [J Transl Med, 2012 Sep 11;10:189. 50314 (5/2104)] Interview PubMed

Cancer (general) - Vitamin D

Vitamin D - incidence rates of cancers of the breast, colon and ovary are much lower in sunny places in the world; cancers of the kidney and endometrium are lower in sunny regions; inverse associations of serum 25(OH)D with cancers of the breast and ovary; and study showing vitamin D levels reduce colon cancer risk. [J Steroid Biochem Molec Biol, 2007;103(3-5):708-711. 45265 (2/2008)] Summary Interview PubMed

Cancer (general) - Vitamin D - 45265

Vitamin D - incidence rates of cancers of the breast, colon and ovary are much lower in sunny places in the world; cancers of the kidney and endometrium are lower in sunny regions; inverse associations of serum 25(OH)D with cancers of the breast and ovary; and study showing vitamin D levels reduce colon cancer risk. [J Steroid Biochem Molec Biol, 2007;103(3-5):708-711. 45265 (2/2008)] Summary Interview PubMed

Cancer (general) - Wheat-germ extract

Wheat-germ extract (fermented, Avemar®) 6 g/m2 orally twice a day (adults 8.5 gms q.d. or b.i.d.) reduced febrile neutropenia risk post-chemotherapy 43%. [J Pediatr Hematol Oncol, October 2004;26(10):631-635. 42296 (01/2005)] Summary Interview PubMed

Cancer (head and neck) - Eicosapentaenoic acid

Cancer (head and neck) Eicosapentaenoic acid (EPA)1.47 grams or 1.61grams per day (n3:n6 ratio of 1.47 and .99 respectively) stabilized weight and serum protein. [Eur Rev Med Pharmacol Sci, 2008;12(3):177-81. 46684 (1/2009)] Summary PubMed

Cancer (Head and Neck) - Eicosapentaenoic acid 2

Eicosapentaenoic acid (EPA)1.47 grams or 1.61grams per day (n3:n6 ratio of 1.47 and .99 respectively) stabilized weight and serum protein. [Eur Rev Med Pharmacol Sci, 2008;12(3):177-81. 46684 (1/2009)] Summary Interview

Cancer (head and neck) - Glutamine

Glutamine 16 g suspension in 240 ml of normal saline given in 30-ml doses, swished for 3 minutes and expectorated 4 times per day significantly reduced the duration and severity of objective oral mucositis during radiotherapy. [Int J Radiation Oncol Biol Phys, 2000;46(3):535-539. 35019 (2000)] Summary Interview PubMed

Cancer (head and neck) - Selenium

Selenium 600 mcg/d (sodium selenite) reduced irradiation-induced supraglottic edema. [Trace Elements Electrolytes, 2002;19(1):33-37. 38846 (2002)] Summary Interview

Cancer (head and neck) - Zinc

Zinc in plasma low. [Int J Clin Pract, July 2004;58(7):662-668. 42200 (12/2004)] Summary Interview PubMed

Cancer (head and neck) - Zinc - 2

Zinc 25 mg (Pro-Z) 3 q.d.. [Int J Radiat Oncol Biol Phys, 2007 Oct 31; [Epub ahead of print]. 45931 (2/2008)] Summary Interview PubMed

Cancer (head and neck) - Zinc sulphate

Zinc sulphate 50 mg t.i.d.. [Int J Clin Pract, July 2004;58(7):662-668. 42200 (12/2004)] Summary Interview PubMed

Cancer (hepatocellular) - Active hexose correlated compound

Active hexose correlated compound (AHCC) 3-6 gm/d. Functional food manufactured from the mycelium of mushrooms is cultured; compounds are extracted; AHCC is obtained through a freeze-dry method. The active component of AHCC is probably an oligosaccharide. AHCC includes a significant amount of alpha-glucan. Mushroom-related functional foods are usually beta-glucan rich. The molecular weight of alpha-glucan is approximately one tenth that of beta-glucan. AHCC enhances natural killer cell activity and acts as a biological response modifier. [J Hepatol, 2002;37:78-86. 40348 (2003)] Summary Interview PubMed

Cancer (hepatocellular) - Branch chain amino acids

Branch chain amino acids at 13 gms/d (Aminoleban EN™, Otsuka Pharmaceutical Co., Ltd., Tokyo) prior to liver resection. [Dig Dis Sci, 2007 May 18; [Epub ahead of print]. 45345 (8/2007)] Summary Interview PubMed

Cancer (hepatocellular) - Glycyrrhizin

Glycyrrhizin I.V. with an average dose of 100 mL 3 times a week (usual dose: 40ml to 100ml once daily, 3-5 times a week) reduced the incidence of HCC from interferon resistant hepatitis C patients. [Hepatol Res, 2007 Sept;37 Suppl 2:S287-93. 46248 (8/2008)] Summary Interview PubMed

Cancer (hepatocellular) - Tea

Tea -10 cups Japanese green tea containing 1 gm tea polyphenols reduced risk. [Mutation Research, 1998;402:307-310. 30770 (1999)] Summary Interview PubMed

Cancer (hepatocellular) - Vitamin K2

Vitamin K2 45 mg/d reduced the incidence of hepatocellular cancer in patients with viral cirrhosis. [Hepatol Res. 2007 Sep;37 Suppl 2:S303-7. 46249 (4/2008)] Summary Interview PubMed

Cancer (hepatocellular) - Vitamin K2 - 2

Vitamin K2 45 mg/d reduced the incidence of hepatocellular cancer in patients with viral cirrhosis. [JAMA, July 21, 2004;292 (3):358-361. 41865 (10/2004)] Summary Interview PubMed

Cancer (hepatocellular) - Zinc sulphate

Zinc sulphate 45 mg t.i.d.. [Cancer, May 15, 1998;82(10):1938-1945. 29900, 30253/30000 (1998)] Summary Interview PubMed

Cancer (lung) - Alpha-ketoglutarate

Alpha-ketoglutarate (AKG) 7.2 g and 5-hydroxymethylfurfural (5-HMF) 720 mg per day (SANOPAL), given in three single doses a day just before breakfast, lunch and dinner. [Eur J Cardiothorac Surg, 2007 Nov;32(5):776-82. Epub 2007 Sep 4. 46255 (07/2008)] Summary Interview PubMed

Cancer (lung) - DHA

DHA 8.2 gm/d and EPA 6.8 gm/d. [Nutr Cancer. 2005;52(2):121-9. 43800/ 44144 (1/2006)] Summary Interview PubMed

Cancer (lung) - Myo-Inositol

Myo-Inositol 18 gm/d (chemoprevention-significant increase in the rate of regression of pre-existing bronchial dysplastic lesions). [Cancer Epidemiol Biomarkers Prev, 2006 Aug;15(8):1526-31. 44653/46297 (11/2006)] Summary Interview PubMed

Cancer (lung) - omega-3 fatty acids - 49100

Lung cancer patients took EPA from fish oil at 2 grams per day, with lesser amounts of DHA, with meals to reduce “fishy burps” as either 5 pills spread throughout the day or 2 teaspoons of syrup. Patients receiving standard of care lost muscle and had higher amounts of fat within their muscle than the group taking fish oil, who did not lose muscle. Fish oil enhanced chemotherapy’s effectiveness at killing the tumor as well as well as improving one year survival. [Curr Opin Clin Nutr Metab Care. 2012 Feb 23. [Epub ahead of print]. 49100 (4/ 2012)] Summary Interview PubMed

Cancer (lung) - omega-3 fatty acids, epa, dha - 48203

Omega 3 fatty acids (EPA 2.0 g + DHA 0.9 g daily total) in divided doses of two cans daily mid meal during chemoradiotherapy. [J Nutr 2010 Oct;140(10):1774-80. Epub 2010 Aug 25] 48203 (12/2010)] Summary Interview PubMed

Cancer (lung) - Supplements

Supplements - broad spectrum vitamins, trace elements and specific fatty acids in pharmacologic doses in combination with regular cancer treatment reduces the risk for metastases and secondary tumors. [Anticancer Research, 1992;12:599-606. 20848 (1995)] Summary Interview PubMed

Cancer (lung) - Tea

Tea -10 cups Japanese green tea containing 1 gm tea polyphenols reduced risk. [Mutation Research, 1998;402:307-310. 30770 (1999)] Summary Interview PubMed

Cancer (lung) - Vitamin E

Vitamin E (dl-alpha-tocopherol acetate) 300 mg b.i.d. and pentoxifylline 400 mg t.i.d. reduced radiation-induced lung toxicity. [Med Oncol, 2007; 24(3): 308-11. 45673 (12/2007)] Summary Interview PubMed

Cancer (nasopharyngeal) - zinc - 47181

Zinc capsules at 75 mg/d (3 x 25 mg Pro-Z: Banner Pharmacaps, High Point, NC) during chemo - and
radiotherapy.
[Larygoscope, 2009 April 28; [Epub ahead of print]. 47181 (6/2009)] Summary Interview PubMed

Cancer (neurologic) - Vitamin E

Vitamin E 300 mg/d (d-alpha tocopherol) reduced cisplatin-induced neurotoxicity. [J Clin Oncol, March 1, 2003;21(5):927-931. 42852 (04/2005)] Summary Interview PubMed

Cancer (oral) - Tobacco chewing/Smoking/Alcohol

Tobacco chewing, smoking and alcohol are risk factors while oral vitamin E and beta-carotene my be preventive. [Arch Otolaryngol Head Neck Surgery, February 1995;121:141-144. 15521, 17678, 23813/22181 (1996)] Summary Interview PubMed

Cancer (oral) - Vitamin E

Vitamin E (alpha tocopherol) 100 mg (25 IU/ kg/day) b.i.d. applied topically, or chewed, swished and swallowed, improved uncomplicated mucositis in chemotherapy treated pediatric cancer patients. Vitamin E 100 mg (25 IU/ kg/day) b.i.d. P.O. after meals may prevent mucositis. [J Clin Pediatr Dent, 2007; 31(3):167-70. 45438 (10/2008)] Summary PubMed

Cancer (ovarian) - Dairy

Dairy product consumption daily with four or more servings showed a 60% increased risk of ovarian cancer. The increased risk was mainly attributed to milk consumption. Yogurt consumption was weakly associated with ovarian cancer. There was a significant positive association between intake of the milk sugar lactose and risk of ovarian cancer. [Am J Clin Nutr, 2004;80:1353-1357. 42306 (12/2004)] Summary Interview PubMed

Cancer (pancreatic) - Coffee enemas

Coffee enemas. [Nutrition and Cancer 1999;33(2):117-124. 32653 (1999)] Summary Interview PubMed

Cancer (pancreatic) - curcumin - 48918

Curcumin 8 grams per day with or without meals with gemcitabine therapy. [Cancer Chemother Pharmacol, 2011 Jul;68(1):157-64. 48918 (11/2011)] Summary Interview PubMed

Cancer (pancreatic) - Diet

Diet of fruits, vegetables, nuts, whole grains and seeds, and with minimal to no animal protein. [Nutrition and Cancer 1999;33(2):117-124. 32653 (1999)] Summary Interview PubMed

Cancer (pancreatic) - overweight - 50253

Being overweight or obese any time in life and the duration of being overweight or obese, especially if diabetic, was associated with an increased risk of pancreatic cancer. Fat, specifically animal fat, and overall poor diet quality may increase the risk to pancreatic cancer. [Am J Clin Nutr. 2013 Oct;98(4):1057-65. 50253 (12/2013)] Summary PubMed

Cancer (pancreatic) - Pancreatic enzymes

Pancreatic enzymes 130 and 160 capsules per day between meals. [Nutrition and Cancer, 1999;33(2):117-124. 32653 (1999)] Summary Interview PubMed

Cancer (pancreatic) - selenium - 49475

Pancreatic cancer risk was inversely related to dietary selenium intake but not other antioxidants consumed or in dietary supplements taken. Selenium supplements negated this benefit. [Cancer, 2012 Dec 21; [Epub ahead of print]. 49475 (2/2013)] Summary Interview PubMed

Cancer (pancreatic) - Supplements

Supplements of vitamins, minerals, trace elements, amino and fatty acids, and animal-derived glandular and organ concentrates. [Nutrition and Cancer 1999;33(2):117-124. 32653 (1999)] Summary Interview PubMed

Cancer (prostate) - broccoli, green tea, pomegranate, turmeric - 50656

A pomegranate, green tea, broccoli and turmeric combination product equaling 150 mg of each ingredient twice a day in capsule form – roughly equivalent to a bowl of broccoli, quarter of a teaspoon of turmeric, 4 cups of green tea and a quarter of a pomegranate a day. [Prostate Cancer Prostatic Dis. 2014 Jun;17(2):180-6. 50656 (1/2015)] Interview PubMed

Cancer (prostate) - Alpha-linolenic acid

Cancer (prostate) Alpha-linolenic acid (ALA) overall intake was associated with increased risk of advanced prostate cancer. ALA rich foods such as flax seed, almonds, walnuts rich in ALA were not associated with prostate cancer risk. [Am J Clin Nutr, 2004;80:204-16. 41819 (09/2004)] Summary Interview PubMed

Cancer (prostate) - coq10, dha, epa, gla, omega-3 fatty acid - 49459

Fatty Acids - omega-3 fatty acids totaling 1.12 g EPA and 0.72 g DHA per day taken as two capsules twice daily after meals; Co10 (ubiquinone) at 400 mg per day as 200 mg every 12 hours after meals; and GLA at 600 mg per day divided as 300 mg every 12 hours after meals resulted in a 30% and 33% decrease and 15% increase respectively in PSA levels. PSA levels were strongly correlated with duration of EPA, CoQ10 and GLA use. These men did not have prostate cancer and were between 40 and 70 years of age and not alcohol or drug dependent. [Br J Nutr, 2012 Nov 30:1-8; [Epub ahead of print]. 49459 (1/2013)] Summary Interview PubMed

Cancer (prostate) - dha, epa, coq10 - 49459

Fatty Acids - omega-3 fatty acids totaling 1.12 g EPA and 0.72 g DHA per day taken as two capsules twice daily after meals; Co10 (ubiquinone) at 400 mg per day as 200 mg every 12 hours after meals; and GLA at 600 mg per day divided as 300 mg every 12 hours after meals resulted in a 30% and 33% decrease and 15% increase respectively in PSA levels. PSA levels were strongly correlated with duration of EPA, CoQ10 and GLA use. These men did not have prostate cancer and were between 40 and 70 years of age and not alcohol or drug dependent.

[Br J Nutr, 2012 Nov 30:1-8; [Epub ahead of print]. 49459 (1/2013)] Summary Interview PubMed

Cancer (prostate) - Diet

Diet - Pritikin Program of a low-fat diet with a good omega-6:omega-3 fatty acids, high in fiber consisting of natural foods, whole grains, fruits and vegetables; 60 minutes of daily aerobic activities as well as stretching and flexibility; and resistance training 3 days per week slowed cultured prostate cell epithelial growth with no change in apoptosis. [Prostate Cancer Prostatic Dis, 2008 Feb 19; [Epub ahead of print]. 46077 (4/2008)] Summary Interview PubMed

Cancer (prostate) - green tea - 50722

Green Tea - Green tea at 6 cups consumed throughout the day (~800 mg of polyphenols per day, EGCG) in prostate cancer patients resulted in green tea polyphenols found in almost all prostate tissues; a decrease of nuclear NFkB (nuclear factor kappa B); a systemic oxidation marker of urinary oxidative DNA damage (8-hydroxydeoxyguanosine) was decreased in men consuming GT; and there was a small, but significant decrease in serum PSA after GT consumption. [Prostate. 2015 Apr;75(5):550-9 50722 (4/2015)] Interview PubMed

Cancer (prostate) - Green tea catechins

Green tea catechins 600 mg/d. [Cancer Res, 2006 Jan 15;66(2):1234-40. 44815 (5/2005)] Summary Interview PubMed

Cancer (prostate) - Insulin

Insulin - hyperinsulinemia is a promoter of clinical prostate cancer. Hyperinsulinemia and other metabolic disorders precede deaths caused by prostate cancer. Insulin levels could be used as a prospective marker of the clinical prostate cancer aggressiveness and the prostate cancer prognosis, regardless of the patient’s prostate cancer stage and grade and the patient’s PSA level. In patients with G1 tumors, the median fasting plasma insulin level was 8.6 mU/l, while in those with G2 tumors it was 9.6 mU/l and in patients with G3 tumors 11.0 mU/l. [Eur J Cancer, 2005 Dec;41(18):2887-95. Epub 2005 Oct 20. 44412 (5/2006)] Summary Interview PubMed

Cancer (prostate) - lycopene, tomato - 50131

Prostate cancer (PCa) risk is lowered by tomato product consumption. [ J Oncol, 2012;2012:271063. Epub 2012 May 28. 50131 (10/2012)] Interview PubMed

Cancer (prostate) - metformin, zyflamend - 50990

Zyflamend one tablet twice daily (i.e. turmeric, holy basil, green tea, oregano, ginger, rosemary, Chinese goldthread, hu zhang, barberry, and basil skullcap), Metformin 500 milligrams twice daily,used alone or in combination as adjunctive therapies in four prostate cancer patients resulted in decreased PSA levels.

[Case Rep Oncol Med. 2015;2015:471861. 50990 (10/2015)] Interview PubMed

Cancer (prostate) - Omega-3 fatty acids

Omega-3 fatty acids (EPA and DHA, not ALA) intake is associated with lower prostate cancer risk. [Am J Clin Nutr, 2004;80:204-16. 41819 (09/2004)] Summary Interview PubMed

Cancer (prostate) - Testosterone

Testosterone does not cause prostate cancer. [Eur Urol, 2006 Nov;50(5):935-9. Epub 2006 Jul 27. 26251/45529 (3/2007)] Summary Interview PubMed

Cancer (prostate) - Walnuts

Walnuts 75 gm (3.0 oz = 3/4 cup) /d. [Nutr J, 2008;7(1):13. 46327 (8/2008)] Summary Interview PubMed

Cancer (radiation therapy) - Antioxidants

Antioxidants (lipid-soluble, e.g., vitamin E and coenzyme Q10) beneficial during radiation therapy while water-soluble antioxidants are too effective against ROS and should not be used during radiation therapy. (N-acetyl cysteine, alpha-lipoic acid, and glutathione). [Nutr Cancer, 2000;37(1):1-18. 36236/35744 (2001)] Summary Interview PubMed
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