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Expert Pearls

Abdominal Pain

Abruptio Placenta



Adenomatous Polyps

Adrenoleukodystrophy (ALD)

Adult Respiratory Diistress Syndrome (ARDS)

Age Related Macular Degeneration




Akathisia (Neuroleptic-Induced)



Allergic Rhinitus


Alzheimer’s Disease


Amyotrophic Lateral Sclerosis (ALS)

Anal Fissure

Anaphylaxis (Exercise-Induced)

Anemia (megaloblastic)

Anger (substance abuse)

Angina Pectoris

Anklyosing Spondylitis

Ann Allergy

Anticoagulation Therapy



Anxiety (substance abusers)

Aphthous Stomatitis


Arthritis (polyarthritis)



Atopic Dermatitis / Eczema

Atrial Fibrillation

Atrophic Vaginitis

Attention-Deficit /Hyperactivity Disorder


Autoimmune Disease

Back Pain

Barrett's Esophagus

Behavior (violent)

Behavior Disorder

Behcet’s Disease

Benign Prostatic Hypertrophy (BPH)


Bone Loss

Breast Feeding



C-Reactive Protein (lowering)


Candidiasis (oral)

Cardiac Function

Cardiomyopathy (idiopathic)

Cardiovascular Disease

Cardiovascular Surgery

Carotid Atherosclerosis

Catabolic State


Celiac Disease


Cerebral Atrophy

Cerebral Hypofusion

Cerebral Palsy

Cerebral Vascular Disease



Cholesterol Lowering


Chronic Disease

Chronic Obstructive Pulmonary Disease (COPD)


Clostridium Dificille (diarrhea)


Colic (infantile)

Common Cold

Complex Regional Pain Syndrome (CRPS)



Coronary Artery/Heart Disease (see also cardiovascular disease)


Cough (URI)

Cow’s Milk

Critical Illness

Crohn’s Disease

Cystic Fibrosis




Dental Caries


Diabetes Mellitus

Diabetic Neuropathy


Diet (general)

Docosahexaenoic Acid (DHA)

Down Syndrome

Dry Eye Syndrome

Dysfunctional Gut Syndrome




Dysplasia (cervical)

Ear Infection



Endothelial Function

Enteritis (radiation-induced)

Enuresis (nocturnal)



Erectile Dysfunction

Erythema Nodosum


Estrogen Metabolism


Exercise (duodenal ulcer)



Fibrinogen (lowering)

Fibrocystic Breast Disease

Fibroids (uterine)



Folic Acid


Fracture (hip)

Fragile X Syndrome (FXS)

Gastroesophageal Reflux Disease (GERD)

Gestational Diabetes

Gingivitis (see also periodontal disease)



Grave’s Disease

Grave’s Ophthalmopathy

Growth and Development


HDL Cholesterol (elevating)


Headache (sleep disorder)

Hearing Loss (Presbycusis)

Heart Failure

Heart Rate Variability (HRV)

Helicobacter Pylori


Hepatic Detoxification

Hepatic Fibrosis

Hepatic Hepatitis

Hepatic Steatosis (non-alcoholic fatty liver disease)

Hepatitis (Viral)

Hepatitis C


Hereditary Hemorrhagic Telangiectasias









Hypertension (ocular)

Hypertriglyceridemia (see triglyceride lowering)


Ideation (paranoid)

Immune Function


Infertility (female)

Infertility (male)


Inflammatory Bowel Disease


Insulin Resistance/Hyperinsulinemia

Intermittent Claudication

Intestinal Permeability

Irritable Bowel Syndrome (IBS)

Ischemic Heart Disease

Kidney Failure / Insufficiency

Kidney Stone

Kidney Transplantation

Lactation (see breast-feeding)

Lactic Acidosis

Lactose Intolerance

Lead Excess/Poisoning


Leukemia - Myelogenous


Lipoprotein (a) (lowering)

Liver Disease



Meibomian Gland Dysfunction




Menopausal Symptoms


Menstrual Pain

Mental Function

Mercury Exposure/Toxicity

Metabolic Syndrome


Migraine Headache



Mitochondrial Cytopathy

Mitral Valve Prolapse


Mood Disorders


Mortality (from cardiovascular disease)

Motion Sickness

Mucositis (radiation-induced)

Multiple Sclerosis

Muscle Damage (exercise-induced)

Muscle Pain

Muscle Soreness

Muscle Strength

Muscle Wasting

Muscular Dystrophy


Myocardial Infarction

Myopathy (skeletal)


Nausea and Vomiting

Nausea and Vomiting (post-surgery)

Necrotizing Enterocolitis (NEC)



Nephropathy (IgA)

Neural Tube Defect (NTD)

Neurologic Disorder

Neuromuscular Disease

Neuropathic Pain


Neuropsychiatric Disorder

Neuropsychological Function

Niacin Therapy


Obsessive Compulsive Disorder

Obstructive Sleep Apnea Syndrome

Ocular Disorder



Otitis Media


Pain (musculoskeletal)

Pain (Neuropathic)


Panic Disorder

Parkinson's Disease

Pelvic Pain

Pemphigus (bullous)

Periodontitis /Periodontal Disease

Peripheral Vascular Disease

Pernicious Anemia

Pet Therapy

Peyronie's Disease


Physical Performance


Pityriasis Rubra Pilaris

Platelet Aggregation



Polycystic Ovarian Syndrome

Portal Hypertension



Premature Delivery

Premature Graying

Premature Infant

Premature Rupture of Fetal Membranes (PROM)

Premenstrual Syndrome




Psychomotor Development

Pulmonary Artery Hypertension


Radiation Exposure


Restless Leg Syndrome

Retinitis Pigmentosa


Rheumatic Disease

Rheumatic Disease

Rheumatoid Arthritis

Rhinitis (allergic)

Salicylate Intolerance





Seasonal Affective Disorder (SAD)




Serous Otitis Media (see otitis media)

Sexual Activity/Behavior

Shock (septic shock)

Sickle Cell Anemia

Silicone Breast Implant Syndrome

Sleep Disorder


Soy Foods



Substance Abuse

Sudden Infant Death Syndrome




Syndrome X

Systemic Lupus Erythematosus (SLE)

Testosterone Replacement Therapy






Trans Fatty acids

Transplantation (renal)


Triglycerides (lowering)

Tuberculosis (Mycobacteria)

Ulcer (duodenal)

Ulcer (gastric - helicobacter pylori)

Ulcer (pressure)

Ulcerative Colitis

Upper Respiratory Infection (URI)

Uric Acid

Urinary Tract Infection

Urticaria (chronic)



Vegan / Vegetarian Diet

Ventricular Function

Very Low Birth Weight Infants

Veterinary Medicine






Warts (genital)

Weight Gain

Wilson Disease

Xerostomia (Dry Mouth)


Depression - aerobic exercise - 22928

Aerobic exercise and fitness reduces depression. [Arch Physical Med Rehab, 1995;76:647-652. 22928 (1996)] Summary Interview PubMed

Depression - aerobic exercise - 33547

Aerobic exercise (e.g., walking, jogging and biking), 3 times per week for 30 minutes per session at an intensity of 70% to 85% of their maximum heart rate reserve. [Arch Intern Med 1999;159.2349-2356. 33547 (2000)] Summary Interview PubMed

Depression - aerobic exercise - 34749/23164

Aerobic exercise 2 to 5 times per week with a duration of 30 to 40 minutes, including 10 minutes of warm-ups (including stretching) and cool down at each session. The exercise should be performed at 60% to 70% of the maximal intensity. [The Physician Sports Med, September 1995;23(9):44-56. 34749/23164 (1996)] Summary Interview PubMed

Depression - aerobic exercise - 37328

Aerobic exercise training consisting of walking on a treadmill daily for 30 minutes at 80% of one’s maximal heart rate followed by interval training x 10 days improved mood. [Br J Sports Med, 2001;35:114-117. 37328 (2001)] Summary Interview PubMed

Depression - aerobic training - 37328

Aerobic training - walking on a treadmill daily 30 min/d followed by interval training program (80 percent of the maximal heart rate). [Br J Sports Med, 2001;35:114-117. 37328 (2001)] Summary Interview PubMed

Depression - antioxidants - 50274

Depression can be treated with anti-inflammatory and antioxidative therapies that include individual or combinations of nutrients such as zinc, coenzyme Q10, glutathione, melatonin, melatonin receptor agonists, allopregnanolone, PDE4 inhibitors, statins, aspirin, sodium benzoate, tryptophan-enriched diets, and antioxidants, including epigallocatechin gallate, curcumin, quercetin, alpha-lipoic acid and resveratrol. A combination of antioxidants used by themselves or with medication include NAC (1.2 g/day), coenzyme Q10 (up to 1.0 g/day) together with curcumin or alpha lipoic acid with minimal side effects. [Curr Pharm Des. 2013 Oct 28. [Epub ahead of print] 50274 (01/2014)] Interview PubMed

Depression - benfotiamine, b1 - 50892

Benfotiamine is a thiamine (B1) given at 600 mg taken in one dose or divided doses with or without meals in males with alcohol dependence reduced psychiatric symptoms including depression. [Drug Alcohol Depend. 2015 Jul 1;152:257-63. 50892 (8/2015)] Interview PubMed

Depression - bipolar - omega-3 fatty acids - 46950

Omega-3 fatty acids EPA 360 mg/day and DHA 1560 mg/day in divided doses with food a.m. and p.m.. [Eur J Clin Nutr, 2009 Jan 21; [Epub ahead of print]. 46950 (6/2009)] Summary Interview PubMed

Depression - bipolar disorder, dha, epa, lna - 48880

Omega-3 fatty acids up to DHA 3.4g, EPA 6.2mg, α-LNA 6.6g or as little as 3g-4g (2-4 capsules) per day. [The Journal of Clinical Psychiatry, 2011 Aug 9 [Epub ahead of print]. 48880 (11/2011)] Summary Interview PubMed

Depression - cholesterol levels - 33674

Cholesterol levels naturally low (<5 mmol/l), not pharmacologically reduced, were associated with depression and suicide. [Br J Psychiatry 1999;175: 259-262. 33674 (2000)] Summary Interview PubMed

Depression - dha, epa - 49885

Fish oil at a lower dose of EPA + DHA dose of 2.4 g/day (EPA 1.6 g + DHA 0.8 g; four capsules/day) and higher dose of 16.2 g/day (high-dose: EPA, 10.8 g + DHA 5.4 g; two tbsp/day) in adolescents with selective serotonin reuptake inhibitor (SSRIs) resistant depression had symptoms decrease significantly in the high-dose group and there was a trend in the low-dose group. [Pharma Nutrition, 2014 April 1;2(2):38-46. 49885 (8/2014)] Summary Interview PubMed

Depression - dha, epa, vitamin e - 49676

DHA 2.0 g, EPA 0.6 g and vitamin E 10 mg (8 x 1 gm capsules) taken with meals, either at one time or in split doses, improved depression scores without side effects. EPA acts to increase cerebral blood flow via eicosanoid metabolism, whereas DHA affects neurotransmission by increasing membrane fluidity, neurite outgrowth, glucose uptake in the brain, neuronal survival and protecting the brain from neurodegeneration.

[Lipids, 2013 Jun 4; [Epub ahead of print]. 49676 (8/2013)] Summary Interview PubMed

Depression - diet - 12081

Diet - eliminate caffeine, sucrose and eat a higher protein and lower carbohydrate diet x 2 weeks. [The Nutrition Report, March 1991;9(3):17,24. 12081 (1996)] Summary Interview

Depression - eicosapentaenoic acid - 44637

Eicosapentaenoic acid (EPA) - 1 gm/d. [Prev Med, 2006 Jan;42(1):4-13. Epub 2005 Dec 7. 44637 (12/2006)] Summary Interview PubMed

Depression - eicosapentaenoic acid - 45042

Eicosapentaenoic acid (EPA) - 2 gm/d (adults). [Am J Psychiatry, 2006 Jun;163(6): 1098-1100. 45042 (7/006)] Summary Interview PubMed

Depression - eicosapentaenoic acid / docosahexaenoic acid - 44385/45042

Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) (EPA/DHA 2:1) - 1 gm/d (children). [Am J Psychiatry, 2006 Jun;163(6):1098-100. 44385/45042 (7/006)] Summary Interview PubMed

Depression - fatty acids - 24849

Fatty acids - severity of depression was correlate with an increased ratio of arachidonic acid (AA) to eicosapentaenoic acid (EPA) in the plasma and erythrocytes. [Lipids, 1996(Supp.):31:S-157- S-161. 24849 (1996)] Summary Interview PubMed

Depression - folic acid - 44283/44868

Folic acid 5 mg/d x 2 months. [Clin Nutr, 2006 Feb;25(1):60-7. Epub 2005 Oct 10. 44283/44868 (6/2006)] Summary Interview PubMed

Depression - folic acid serum - 44283/44868

Folic acid serum < 3.1 ng/ml. [Clin Nutr, 2006 Feb;25(1):60-7. Epub 2005 Oct 10. 44283/44868 (6/2006)] Summary Interview PubMed

Depression - green tea - 50050

Green tea consumption in ascending order of intake 1 to 5 or more cups per day is associated with a reduction in functional disability (cognitive function, depression, psychological distress, stroke) and healthy life expectancy, in a dose dependent fashion. [Am J Clin Nutr. 2012 March;95(3):732–739. 50050 (5/2012)] Interview PubMed

Depression - hypericum extract - 33969

Hypericum extract 350 mg (STEI 300 extract) equivalent to 2 gm of dried herb at 6 gms/d (1050 mg/d). [BMJ December 11, 1999;319:1534-1539. 33969 (2000)] Summary Interview PubMed

Depression - inositol - 23703

Inositol 6-12 gm/d of oral powder mixed in juice. [Psychopharmacology Bulletin, 1995;31:167-175. 23703 (1995)] Summary Interview PubMed

Depression - klamath microalgae extract - 48291

Klamath microalgae extract, Klamin® 1 tablet (800 mg) 1 hour after breakfast and 1 tablet an hour before dinner in menopausal women. [Minerva Ginecol, 2010;62(5):381-8. 48291 (11/2010)] Summary Interview PubMed

Depression - menopausal - melatonin - 38002/44837

Melatonin 3 mg qhs 10-11 p.m.. [Ann N Y Acad Sci, 2005 Dec;1057:393-402. 38002/44837 (6/2006)] Summary Interview PubMed

Depression - omega-3 fatty acids - 44481/45041

Omega-3 fatty acids (EPA>DHA) 1 gm/d. [Am J Psychiatry, 2006 Jun;163(6): 96978. 44481/45041 (8/2006)] Summary Interview PubMed

Depression - omega-6:omega-3 polyunsaturated fatty acids - 24849

Omega-6:omega-3 polyunsaturated fatty acids in the Western diet is between 10 - 20:1 may increase risk to depression compared with estimates of about 1:1 in the diet of our hunter-gatherer ancestors. [Lipids, 1996(Supp.): 31:S-157- S-161. 24849 (1996)] Summary Interview PubMed

Depression - processed food - 47563

Whole food diets containing large amounts of vegetables, fruits and fish reduced the incidence of depression while processed food diets containing large amounts of sweetened desserts, fried foods,processed meat, refined grains and high-fat dairy products increased the risk to depression. [Br J Psychiatry, 2009; 195(5): 408-13. 47563 (1/2010)] Summary Interview PubMed

Depression - s-adenosyl-l-methionine - 42868

S-adenosyl-l-methionine (SAMe) 800-1600 mg/d. [J Clin Psychopharmacol, December 2004;24(6):661-664. 42868 (04/2005)] Summary Interview PubMed

Depression - st. john's wort - 43182

St. John's Wort Extract WS® 5570 (hypericum extract (LI160); standardized to 3-6% hyperforin and 0.12-0.28 % hypericin) 900-1800 mg/d. [BMJ, March 5, 2005;330:503-506. 43182 (6/2005)] Summary Interview PubMed

Depression - st. john’s wort - 38145

St. John’s Wort - 2 x 1 tablet of 250 mg St. John’s Wort extract Ze 117 daily (ethanol 50% (m/m);drug-extract ratio 4-7:1; 0.2% total hypericin;<1% hyperforin). [Pharmacopsychiatry, 2001;34(Suppl 1):S49-S50. 38145 (2002)] Summary Interview

Depression - st. john’s wort - 46729

St. John’s Wort extract 500-900 mg/d (up to 1800 mg/d) benefits major depression. [Cochrane Database Syst Rev, 2008 Oct 8;(4):CD000448. 46729 (10/2008)] Summary Interview PubMed

Depression - vitamin b12 - 28725

Vitamin B12 normal ranges should be 600 to 2000 pg/ml. Below 550 to 600 pg/ml deficiencies start to appear in the CSF. Humans are born with serum levels of about 2000 pg/ml, which decline gradually throughout life. [Medical Hypotheses, 1991;34:131-140. 28725 (1998)] Summary Interview PubMed

Depression - vitamin b12 - 35168

Vitamin B12 500-1000 mcg/d orally. [Am J Psychiatry, 2000;157:715-721. 35168 (2000)] Summary Interview PubMed

Depression - vitamin b12 - 35168

Vitamin B12 deficiency - higher methylmalonic acid (MMA; more than 271 nmol/L) in combination with low serum vitamin B12 levels (less than 258 pmol/L for a high cut-off and more than 148 pmol/L for a low cut off) associated with depression. [Am J Psychiatry, 2000;157;715-721. 35168 (2000)] Summary Interview PubMed

Depression - vitamin b12 - 44283/44868

Vitamin B12 1000 mcg/d IM x two weeks; t.i.w. x 2 weeks; weekly x 4 weeks; then 1000 to 2000 mcg/ day orally. [Clin Nutr, 2006 Feb;25(1):60-7. Epub 2005 Oct 10. 37838, 44283/44868 (6/2006)] Summary Interview PubMed

Depression - vitamin b12 - 44868

Vitamin B12 serum < 200 pg/ml. [Clin Nutr, 2006 Feb;25(1):60-7. Epub 2005 Oct 10. 44868 (6/2006)] Summary Interview PubMed

Depression - vitamin c, fluoxetine - 49560

Vitamin C at 1000 mg given once daily after a meal with fluoxetine (10–20 mg/day) in pediatric patients with major depressive disorder significant decrease in depressive symptoms compared to the fluoxetine plus placebo group. There were no serious side effects and the compliance was excellent. Nutr J, March 9, 2013;12:31. 49560 (4/2013)] [Nutr J, March 9, 2013;12:31. 49560 (4/2013)] Summary Interview PubMed

Depression - vitamin d3 - 46728

Vitamin D3 20,000 - 40,000 IU/week by mouth. [J Intern Med, Sept 2008; [Epub ahead of print]. 46728 (11/2008)] Summary Interview PubMed

Depression - zinc - 47058

Zinc 25 mg (hydroaspartate) after breakfast improved response in imipramine resistant patients. [J Affect Disord, 2009 March 9; [Epub ahead of print]. 47058 (6/2009)] Summary Interview PubMed

Diabetes Mellitus - 5-hydroxy-tryptophan - 30375

5-hydroxy-tryptophan (5-HTP) 750 mg/d reduced carbohydrate intake and cravings in non-insulin dependent diabetics. [Intern J Obesity, 1998; 22:628-654. 30375 (1998)] Summary

Diabetes Mellitus - alpha lipoic acid - 47306

Alpha lipoic acid 400 mg/d. [Aging Clinical and Experimental Research, 2009;21(2):198. 47306 (10/2009)] Summary Interview PubMed

Diabetes Mellitus - alpha-linolenic acid - 44946

Alpha-linolenic acid (diet) increased fasting insulin. [Obesity (Silver Spring), 2006 Feb;14(2):295-300. 44946 (9/2006)] Summary Interview

Diabetes Mellitus - alpha-lipoic acid - 45077

Alpha-lipoic acid 600 mg q. 12 hrs, 30 minutes before meals improved insulin sensitivity and glucose disposal rate. [Hormones (Athens), 2006; 5(4): 251-8. 45077 (6/2007)] Summary

Diabetes Mellitus - beta-glucan - 48935

Beta glucan (barley) 3g/d and 6g/d per day given as a flavored water beverage (1g or 2g dose) taken in a divided dose 3 times a day with meals. [Nutr Metab (Lond), 2011 Aug 16; 8:58. 48935 (12/2011)] Summary Interview PubMed

Diabetes Mellitus - breakfast - 50243

Breakfast – Irregular breakfast consumption (0–6 times/wk) increase type 2 diabetes risk in older women. [Am J Clin Nutr. 2013 Aug;98(2):436-43. 50243 (8/2103)] Interview PubMed

Diabetes Mellitus - breast-feeding - 27905

Breast-feeding - being exclusively breast-fed for at least two months reduced risk to diabetes in Pima Indians by 50% compared to those not breast-fed. [The Lancet, July 19, 1997;350:166-168. 27905 (1997)] Summary Interview

Diabetes Mellitus - caffeine - 41815

Caffeine at 5 mg/kg body weight increased insulin resistance in obese non-diabetics. [Am J Clin Nutr,2004;80:22-28. 41815 (2004)] Summary Interview

Diabetes Mellitus - carnitine - 47974

Carnitine (L)1 gram two times daily before main meals. [JPEN J Parenter Enteral Nutr, 2010 May- June;34(3): 295-9. 47974 (7/2010)] Summary Interview PubMed

Diabetes Mellitus - carotid atherosclerosis, fruit, vegetables, yogurt - 51046

Diabetic subjects consuming more fruit and vegetables and dairy products (yogurt), suggesting improved diet quality, had a greater reduction in carotid intima media thickness. (Note: dairy foods actually weren’t increased in the intervention group as expected, though the intervention group had a higher intake of yogurt, along with more fruits and vegetables). [Am J Clin Nutr. 2015 Oct;102(4):771-9. 51046 (12/2015)] Interview PubMed

Diabetes Mellitus - chromium - 44312

Chromium - yeast bound 400 mcg/d. [Biol Trace Elem Res, 2006;109(3):215-30. 44312 (7/2006)] Summary Interview

Diabetes Mellitus - cinnamon - 45393 / 46012

Cinnamon 6 gms/d. [Am J Clin Nutr. 2007 Jun;85(6):1552-6. 45393/46012 (10/2007)] Summary Interview

Diabetes Mellitus - cinnamon - 48116

Cinnamon bark powder 1 gram daily with breakfast. [J Am Board Fam Med, 2009; 22(5): 507-12. 48116 (9/2010)] Summary Interview PubMed

Diabetes Mellitus - cow’s milk - 37796

Cow’s milk (fermented or non-fermented) is insulinemic and insulinotrophic but low glycemic. [Am J Clin Nutr, 2001;74:96-100. 37796 (2001)] Summary Interview

Diabetes Mellitus - curcumin - 49352

Curcumin in a 150 mg capsule 30 minutes after breakfast and another 30 minutes after supper significantly decreased fasting blood glucose, the insulin resistance index (HOMA-IR), serum total FFAs and triglycerides while increasing LPL activity. No side effects were noted. [Nutr Food Res, 2012 Aug 29; [Epub ahead of print]. 49352 (10/2012)] Summary Interview PubMed

Diabetes Mellitus - curcumin, tumeric - 49279

Curcumin 3 250 mg capsules of dried rhizomes of turmeric (Curcuma longa Linn.) two times daily after breakfast and dinner (1.5 gm/d). [Diabetes Care, 2012 Jul 6; [Epub ahead of print]. 49279 (8/2012)] Summary Interview PubMed

Diabetes Mellitus - daflon® - 34595

Daflon® 500 (containing 450 mg diosmin and 50 mg hesperidin) q.i.d. a day with meals. [Diab Nutr Metab, 1999;12:256-263. 34595 (2000)] Summary Interview

Diabetes Mellitus - diet - 21878

Diet - reduces neuropathy with vegan diet which excludes any food or drink that comes from animal, fish, meat, milk or eggs; excludes refined foods such as free fats (oil, shortening or margarine, etc.); free carbohydrates (sugar, syrups, starch, etc.); or refined cereals (white rice, white flour, etc.); or refined legumes (soy protein isolate or soy protein concentrate products). Eat only whole nuts, beans, seeds, whole grains, fruit and vegetables. [J Nutritional Med, 1994;4:431-439. 21878] Summary Interview

Diabetes Mellitus - diet - 44514

Diet - low-fat, low-glycemic, high fiber vegan diet (reduced HA1c, weight, cholesterol). [Diabetes Care, 2006; 29(8):1777-83. 44514 (8/2006)] Summary Interview

Diabetes Mellitus - diet, vegetarian - 50846

Vegetarian diets prevent and treat type 2 diabetes. [J Am Coll Nutr. 2015 Apr 27:1-11. [Epub ahead of print] 50846 (6/2015)] Interview PubMed

Diabetes Mellitus - flax gum - 47282

Flax gum 5 gm per day from 6 wheat chapattis. [Int J Food Sci Nutr, 2009 Jun 22; [Epub ahead of print]. 47282 (9/2009)] Summary Interview PubMed

Diabetes Mellitus - flaxseed - 47387

Flaxseed-derived lignan capsules at 360 mg lignan per day. [Am J Clin Nutr 2009;90:288-97. 47387 (7/2011)] Summary Interview PubMed

Diabetes Mellitus - flaxseed-derived lignans - 45832

Flaxseed-derived lignans (FDL) 120 mg t.i.d. before or after meals but not with meals. [PLoS ONE, 2007; 2(11): e1148. 45832 (1/2008)] Summary Interview

Diabetes Mellitus - fluoroquinolones, magnesium, tendinopathy - 50453

Fluoroquinolones may induce an intracellular magnesium deficit that can lead to insulin resistance and the subsequent development of type 2 diabetes. Induced magnesium deficiency may also be a partial cause of fluoroquinolone-induced tendinopathy. [Med Hypotheses. 2014 May 29. pii: S0306-9877(14)00217-5. 50453 (8/2104)] Interview PubMed

Diabetes Mellitus - ginkgo biloba extract - 43223

Ginkgo biloba extract (EGb 761) 120 mg q.a.m.. [Diabetes Research and Clinical Practice, 2005;68:29-38. 43223 (7/2005)] Summary Interview

Diabetes Mellitus - green tea, pomegranate, vitamin c - 47602

PomGT tablet  (pomegranate extract (500 mg), green tea extract (300 mg) and vitamin C (60 mg) per tablet)1 capsule 2 hours after dinner. [J Endocrinol Invest, 2009 Oct 15; (DOI: 10.3275/6564 ) [Epub ahead of print] 47602 (01/2010)] Summary Interview PubMed

Diabetes Mellitus - hibiscus sabdariffa - 46873

Hibiscus Sabdariffa (Sour Tea) tea infusions b.i.d. in diabetics. [J Hum Hypertens, 2008 Aug 7; [Epub ahead of print]. 46873 (4/2009)] Summary Interview PubMed

Diabetes Mellitus - infant feeding - 40942

Infant feeding guidelines to reduced risk to developing autoantibodies to Islet cells/autoimmune type I diabetes mellitus - exclusively breast-feed, or if breast-feeding is not possible, milk-formula feed their newborns until 6 months of age. The first recommended solid foods introduced after 6 months of age are vegetables (mostly carrots), followed by meat and potatoes, and then cereals from 7 months of age. [JAMA, October 1, 2003;290(13):1721-1728. 40942 (2004)] Summary Interview

Diabetes Mellitus - infant feeding - 40942

Infant feeding - early introduction of gluten-containing food is a risk factor for the development of type 1 diabetes associated autoimmunity in children of parents with type 1 DM with the HLA-DR3/DR4-DQ8 genotype. [JAMA, October 1, 2003;290(13):1721-1728. 40942 (2004)] Summary Interview

Diabetes Mellitus - infant feeding - 40942

Infant feeding - the prevalence of islet autoimmunity could be reduced if all families complied with infant feeding guidelines and did not introduce gluten-containing and solid foods to infants until after age 3 months. [JAMA, October 1, 2003;290(13):1721-1728. 40942 (2004)] Summary Interview

Diabetes Mellitus - interval walking - 49462

Interval walking for 60 minutes, 5 days per week in type 2 diabetics, defined as alternating between 3 minutes of high speed walking and 3-minutes of low speed walking (high speed walking is the equivalent of the fastest speed you can possibly walk without breaking into a jog), showed statistically-significant improvements in body weight, abdominal visceral adiposity, VO2 peak, LDL-cholesterol, fasting insulin, and CGM glucose. The continuous walking group showed no improvement, but had no decline in the above parameters. The control group showed a decline in the above parameters. [Diabetes Care, 2012 Sept 21; [Epub ahead of print]. 49462 (2/20013)] Summary Interview PubMed

Diabetes Mellitus - lithium carbonate - 31480

Lithium carbonate 100 mg/d. [Biological Trace Element Research,1997;60:131-137. 31480 (1999)] Summary Interview

Diabetes Mellitus - magnesium - 48178

Magnesium pidolate, a bioavailable organic salt, given by mouth at a dose of 4.5 grams per day
providing 368 milligrams of elemental magnesium in two divided doses (morning and evening), with
or without meals improve endothelial function.
[Magnes Res, 2010 Aug 24; [Epub ahead of print]. 48178 (10/2010)] Summary Interview PubMed

Diabetes Mellitus - magnesium chloride - 41392

Magnesium chloride 2.5 gm/d (325 mg elemental magnesium) by taking 50 ml of a magnesium chloride solution (50 g of magnesium chloride per 1000 ml makes a 5% solution). [Diabetes Care, April 2003;26(4):1147-1152. 41392 (2004)] Summary Interview

Diabetes Mellitus - magnesium deficiency - 23713

Magnesium deficiency common. [Ann Nutr Metab, 1995;39:217-223. 23713 (1996)] Summary Interview

Diabetes Mellitus - magnesium deficiency - 43396

Magnesium deficiency is (lower [Mg2+]) is associated with a faster renal function deterioration rate in DMII patients. [Clin Nephrology, July 2005;63(6): 429-436. 43396 (8/2005)] Summary Interview

Diabetes Mellitus - magnesium oxide - 43396

Magnesium oxide 400 mg P.O. b.i.d. if proven deficient by serum magnesium is less than or equal to 1.6 mg/dl. [Clin Nephrology, July 2005;63(6):429-436. 43396 (8/2005)] Summary Interview

Diabetes Mellitus - Melatonin - 50209

Lower urinary melatonin secretion was independently associated with a higher risk of developing type 2 diabetes. Lower melatonin secretion has been shown to be associated with increased insulin resistance. Too little (less than 6 hours) and too much sleep (greater than 9 hours) have been associated with increased incidence of diabetes. Red meat has been associated with lower levels of melatonin secretion. [JAMA, April 3, 2013;309(13):1388-1396. 50209 (4/2013)] Interview PubMed

Diabetes Mellitus - n-acetylcysteine - 50370

N-acetylcysteine may be beneficial in a wide range of conditions with oxidative stress and depleted intracellular glutathione including acetaminophen overdose, diabetic atherothrombosis, cystic fibrosis and contrast-induced nephropathy. It’s effectiveness may be dose-dependent with the degree of glutathione depletion. In acetaminophen overdose dosing has been three consecutive intravenous infusions of 150, 50, 100 mg/kg respectively each over 1 hour and oral and nebulized doses between 700-2800 mg/d. [Pharmacol Ther. 2014 Feb;141(2):150-9. 50370 (6/2014)] Interview PubMed

Diabetes Mellitus - omega-3 fatty acids - 46407

Omega-3 fatty acids (2 g/d DHA and 3 g/d EPA, fish oil) in 3 divided doses with meals increased stroke volume and cardiac output. [Eur J Appl Physiol, 2008 June 18; [Epub ahead of print]. 46407 (8/2008)] Summary Interview

Diabetes Mellitus - periodontitis, zinc - 50739

Zinc insufficiency as measured in the serum, saliva or gingival tissues in individuals with both periodontitis and diabetes may warrant supplementation and be beneficial in both these conditions. [Curr Diabetes Rev. 2014;10 (6):397-401. 50739 (4/2015)] Interview PubMed

Diabetes Mellitus - pomegranate - 46918

Pomegranate juice 50 ml/d or pomegranate polyphenol extract 5 mL/d in a single dose with a meal reduced atherosclerotic risk. [J Agric Food Chem, 2008; 56(18): 8704-13. 46918 (3/2009)] Summary Interview PubMed

Diabetes Mellitus - pomegranate juice - 50230

Pomegranate juice 1-2 ml/kg (70 kg = 70-140 ml; 240 ml = 1 cup = 8 oz) reduces insulin resistance, fasting blood sugar and oxidative stress which makes it useful in diabetes type 1 and 2, cardiovascular disease and cancer. [ Nutr Res 2013 May;33(5):341-8. 50230 (2/2014)] Interview PubMed

Diabetes Mellitus - probiotic - lactobacillus rhamnosus gg - bifidobacterium bb12 - 47769

Probiotics Lactobacillus rhamnosus GG and Bifidobacterium lactis Bb12 at 1010 CFU per day of each strain in capsules given once daily in healthy pregnant females from the first trimester through the end of exclusive breast feeding was safe and reduced the incidence of gestational diabetes. [ Br J Nutr., 2010 Feb 4:1-8. [Epub ahead of print]. 47769 (4/2010)] Summary Interview PubMed

Diabetes Mellitus - protein - 46326

Protein (30% soy protein, 35% textured soy protein and 35% animal protein) .8 mg/kg/d. [Diabetes Care, 2008; 31(4): 648-54. 46326 (8/2008)] Summary Interview

Diabetes Mellitus - sesame oil - 48437

Sesame oil 35 grams per day with a fatty acid breakdown of 15.23g of linoleic acid (omega-6)/35g of oil and 14.42g of oleic acid (MUFA)/35g of oil. [Clin Nutr, 2010 Dec 15; [Epub ahead of print]. 48437 (4/2011)] Summary Interview PubMed

Diabetes Mellitus - taurine - 44368 / 44736

Taurine .5-1.5 gm/d. [Curr Opin Clin Nutr Metab Care, 2006 Jan;9(1):32-6. 44368/44736 (6/2006)] Summary Interview

Diabetes Mellitus - thiamin - 46881

Thiamin 100 mg x 3 daily; one at breakfast, one in the early afternoon and one in the evening in type 2 diabetic patients (21 male, 19 female) showed improvement in kidney function. [Diabetologia, 2008 Dec 5; [Epub ahead of print]. 46881 (2/2009) Summary Interview PubMed

Diabetes Mellitus - tomato juice - 35817

Tomato juice 500 ml/d. [Diabetes Care, June, 2000;23(6):733-738. 35817 (2000)] Summary Interview

Diabetes Mellitus - vanadium - 32657

Vanadium (inorganic vanadium as vanadyl sulfate, vanado-tartrate and sodium meta vanadate) 20-50 mg/d of elemental vanadium per day. [J Altern Complement Med, 1999;5(3):273-291. 32657 (1999)] Summary Interview

Diabetes Mellitus - vanadium - 32657

Vanadium (organic vanadium as Bis-maltolato oxovanadium or bis-glycinato-oxovanadium) 300 mcg of elemental vanadium per tablet, taken 1 to 3 times a day. [J Altern Complement Med, 1999;5(3):273-291. 32657 (1999)] Summary Interview

Diabetes Mellitus - vanadyl sulphate - 37127

Vanadyl sulphate 150 mg/d. [J Clin Endocrinol Metab, March, 2001:86(3):1410-1417. 37127 (2001)] Summary Interview

Diabetes Mellitus - vinegar - 45692

Vinegar (apple cider) 2 tablespoons before bed lowered morning fasting blood glucose. [Diabetes Care, published ahead of print, published online August 21, 2007. 45692 (11/2007)] Summary Interview

Diabetes Mellitus - vitamin b1 - 25833

Vitamin B1 benfothiamine 3 x 100 mg/d for 2 to 3 weeks and thereafter a dose of 1 to 2 x 100 mg/d benefitted diabetic polyneuropathy. [Exp Clin Endocrinol Metab, 1996;104:311-316. 25833 (1997)] Summary Interview

Diabetes Mellitus - vitamin b1 - 45096

Vitamin B1 - Vitamin B1 100 mg I.V. x 1 week, then 50 mg P.O. b.i.d. then 50 mg/d P.O. as maintenance eliminated the need for transfusions, normalized hemoglobin and platelets, and improved diabetic control in a child born with a thiamine transporter gene mutation. The case was an 18-year-old girl who was born deaf-mute, had diabetes at age 9 months and severe anemia at age 2 years who could only be treated with transfusions for 17 years. [Eur J Endocrinol, 2006;155(6):787-792. 45096 (6/2007)] Summary Interview

Diabetes Mellitus - vitamin b6 - 20478

Vitamin B6 4-6 mg/d. [Biochem Metab Biol, 1994;52:10-17. 20478 (1996)] Summary Interview

Diabetes Mellitus - vitamin b6 - 20478

Vitamin B6 insufficiency can occur in diabetics with persistent hyperglycemia; vitamin B6 deficiency can aggravate diabetes. Vitamin B6 in its active form, pyridoxal phosphate, controls and regulates the intermediate metabolism of insulin. [Biochemical and Metabolic Biology, 1994;52: 10-17. 20478 (1996)] Summary Interview

Diabetes Mellitus - vitamin c - 23713

Vitamin C 2000 mg/d (reduced lipids improved glycemic control) and vitamin E 600 mg/d (lowered blood pressure). [Ann Nutr Metab, 1995;39:217-223. 23713 (1996)] Summary Interview

Diabetes Mellitus - vitamin c - 23713

Vitamin C levels are inversely related to glycemic control. [Ann Nutr Metab, 1995;39:217-223. 23713 (1996)] Summary Interview

Diabetes Mellitus - vitamin c - 42312

Vitamin C 300 mg/d or more (supplemented) increased the cardiovascular disease death rate in postmenopausal diabetic patients. [Am J Clin Nutr, 2004;80:1194-2000. 42312 (12/2004)] Summary Interview

Diabetes Mellitus - vitamin d - 26930

Vitamin D improves insulin sensitivity and glucose tolerance. [Diabetologia, 1997;40:344-347. 26930 (1997)] Summary Interview
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