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Expert Pearls

Abdominal Pain

Abruptio Placenta



Adenomatous Polyps

Adrenoleukodystrophy (ALD)

Adult Respiratory Diistress Syndrome (ARDS)

Age Related Macular Degeneration




Akathisia (Neuroleptic-Induced)



Allergic Rhinitus


Alzheimer’s Disease


Amyotrophic Lateral Sclerosis (ALS)

Anal Fissure

Anaphylaxis (Exercise-Induced)

Anemia (megaloblastic)

Anger (substance abuse)

Angina Pectoris

Anklyosing Spondylitis

Ann Allergy

Anticoagulation Therapy



Anxiety (substance abusers)

Aphthous Stomatitis


Arthritis (polyarthritis)



Atopic Dermatitis / Eczema

Atrial Fibrillation

Atrophic Vaginitis

Attention-Deficit /Hyperactivity Disorder


Autoimmune Disease

Back Pain

Barrett's Esophagus

Behavior (violent)

Behavior Disorder

Behcet’s Disease

Benign Prostatic Hypertrophy (BPH)


Bone Loss

Breast Feeding



C-Reactive Protein (lowering)


Candidiasis (oral)

Cardiac Function

Cardiomyopathy (idiopathic)

Cardiovascular Disease

Cardiovascular Surgery

Carotid Atherosclerosis

Catabolic State


Celiac Disease


Cerebral Atrophy

Cerebral Hypofusion

Cerebral Palsy

Cerebral Vascular Disease



Cholesterol Lowering


Chronic Disease

Chronic Obstructive Pulmonary Disease (COPD)


Clostridium Dificille (diarrhea)


Colic (infantile)

Common Cold

Complex Regional Pain Syndrome (CRPS)



Coronary Artery/Heart Disease (see also cardiovascular disease)


Cough (URI)

Cow’s Milk

Critical Illness

Crohn’s Disease

Cystic Fibrosis




Dental Caries


Diabetes Mellitus

Diabetic Neuropathy


Diet (general)

Docosahexaenoic Acid (DHA)

Down Syndrome

Dry Eye Syndrome

Dysfunctional Gut Syndrome




Dysplasia (cervical)

Ear Infection



Endothelial Function

Enteritis (radiation-induced)

Enuresis (nocturnal)



Erectile Dysfunction

Erythema Nodosum


Estrogen Metabolism


Exercise (duodenal ulcer)



Fibrinogen (lowering)

Fibrocystic Breast Disease

Fibroids (uterine)



Folic Acid


Fracture (hip)

Fragile X Syndrome (FXS)

Gastroesophageal Reflux Disease (GERD)

Gestational Diabetes

Gingivitis (see also periodontal disease)



Grave’s Disease

Grave’s Ophthalmopathy

Growth and Development


HDL Cholesterol (elevating)


Headache (sleep disorder)

Hearing Loss (Presbycusis)

Heart Failure

Heart Rate Variability (HRV)

Helicobacter Pylori


Hepatic Detoxification

Hepatic Fibrosis

Hepatic Hepatitis

Hepatic Steatosis (non-alcoholic fatty liver disease)

Hepatitis (Viral)

Hepatitis C


Hereditary Hemorrhagic Telangiectasias









Hypertension (ocular)

Hypertriglyceridemia (see triglyceride lowering)


Ideation (paranoid)

Immune Function


Infertility (female)

Infertility (male)


Inflammatory Bowel Disease


Insulin Resistance/Hyperinsulinemia

Intermittent Claudication

Intestinal Permeability

Irritable Bowel Syndrome (IBS)

Ischemic Heart Disease

Kidney Failure / Insufficiency

Kidney Stone

Kidney Transplantation

Lactation (see breast-feeding)

Lactic Acidosis

Lactose Intolerance

Lead Excess/Poisoning


Leukemia - Myelogenous


Lipoprotein (a) (lowering)

Liver Disease



Meibomian Gland Dysfunction




Menopausal Symptoms


Menstrual Pain

Mental Function

Mercury Exposure/Toxicity

Metabolic Syndrome


Migraine Headache



Mitochondrial Cytopathy

Mitral Valve Prolapse


Mood Disorders


Mortality (from cardiovascular disease)

Motion Sickness

Mucositis (radiation-induced)

Multiple Sclerosis

Muscle Damage (exercise-induced)

Muscle Pain

Muscle Soreness

Muscle Strength

Muscle Wasting

Muscular Dystrophy


Myocardial Infarction

Myopathy (skeletal)


Nausea and Vomiting

Nausea and Vomiting (post-surgery)

Necrotizing Enterocolitis (NEC)



Nephropathy (IgA)

Neural Tube Defect (NTD)

Neurologic Disorder

Neuromuscular Disease

Neuropathic Pain


Neuropsychiatric Disorder

Neuropsychological Function

Niacin Therapy


Obsessive Compulsive Disorder

Obstructive Sleep Apnea Syndrome

Ocular Disorder



Otitis Media


Pain (musculoskeletal)

Pain (Neuropathic)


Panic Disorder

Parkinson's Disease

Pelvic Pain

Pemphigus (bullous)

Periodontitis /Periodontal Disease

Peripheral Vascular Disease

Pernicious Anemia

Pet Therapy

Peyronie's Disease


Physical Performance


Pityriasis Rubra Pilaris

Platelet Aggregation



Polycystic Ovarian Syndrome

Portal Hypertension



Premature Delivery

Premature Graying

Premature Infant

Premature Rupture of Fetal Membranes (PROM)

Premenstrual Syndrome




Psychomotor Development

Pulmonary Artery Hypertension


Radiation Exposure


Restless Leg Syndrome

Retinitis Pigmentosa


Rheumatic Disease

Rheumatic Disease

Rheumatoid Arthritis

Rhinitis (allergic)

Salicylate Intolerance





Seasonal Affective Disorder (SAD)




Serous Otitis Media (see otitis media)

Sexual Activity/Behavior

Shock (septic shock)

Sickle Cell Anemia

Silicone Breast Implant Syndrome

Sleep Disorder


Soy Foods



Substance Abuse

Sudden Infant Death Syndrome




Syndrome X

Systemic Lupus Erythematosus (SLE)

Testosterone Replacement Therapy






Trans Fatty acids

Transplantation (renal)


Triglycerides (lowering)

Tuberculosis (Mycobacteria)

Ulcer (duodenal)

Ulcer (gastric - helicobacter pylori)

Ulcer (pressure)

Ulcerative Colitis

Upper Respiratory Infection (URI)

Uric Acid

Urinary Tract Infection

Urticaria (chronic)



Vegan / Vegetarian Diet

Ventricular Function

Very Low Birth Weight Infants

Veterinary Medicine






Warts (genital)

Weight Gain

Wilson Disease

Xerostomia (Dry Mouth)


Diabetes Mellitus - vitamin d - 43749

Vitamin D adequacy reduces risk to type I and type II diabetes. [Diabetologia, 2005 Jul;48(7):1247-57. Epub 2005 Jun 22. 43749 (11/2005)] Summary Interview

Diabetes Mellitus - vitamin d - 44798 / 45399

Vitamin D levels inversely correlated; hypovitaminosis D more frequent in diabetes mellitus. [Clin Endocrinol (Oxf). 2006 Nov;65(5):593-597. 44798/45399 (1/2007)] Summary Interview

Diabetes Mellitus - vitamin d - 48343

Vitamin D 4000 IU per day in type 1 diabetes reduces HgA1c levels. [Ann Saudi Med, 2010;30(6):454-8. 48343 (02/2011)] Summary Interview PubMed

Diabetes Mellitus - vitamin d - 50182

Vitamin D at 2000 IU per day orally in a single dose at breakfast in new onset type 1 diabetics (adolescents and children) along with intensive insulin therapy showed vitamin D is safe and produced a protective immunologic profile (increased regulatory T cells) and slowed the decline of residual β-cell function. Vitamin D deficiency was defined as a level of less than 20 ng/ml; a level between 21 to 29 ng/ml was considered insufficient; and 30ng/ml sufficient. [Arch Pediatr Adolesc Med. 2012 Jul 1;166(7):601-7. 50182 (3/2013)] Interview PubMed

Diabetes Mellitus - vitamin d3 - 48966

Vitamin D3 in serum of pregnant females was inversely related to diabetes type 1 incidence. Development before the age of 15 was more than twofold higher for the offspring of women with the lowest levels of vitamin D compared to the offspring of those with levels above the upper quartile. [Diabetes, January, 2012;61(1):175-8. 48966 (1/2012)] Summary Interview PubMed

Diabetes Mellitus - vitamin e - 28522

Vitamin E 15 mg/kg body weight and nicotinamide 25 mg/kg body weight preserved beta cell function in early onset type I diabetes. [Eur J Endocrinol, 1997;137:234-239. 28522 (1997)] Summary Interview

Diabetes Mellitus - vitamin e - 34596

Vitamin E 600 mg/d. [Hypertension, 1999;34(Part II):1002-1006. 34596 (2000)] Summary Interview

Diabetes Mellitus - vitamin e - 35817

Vitamin E 800 IU/d. [Diabetes Care, June, 2000;23(6):733-738. 35817 (2000)] Summary Interview

Diabetes Mellitus - vitamin e - 45860

Vitamin E 400 IU/d (d-alpha tocopherol) in Hp 2-2 genotype subjects reduce CVD events in by half versus placebo. [Arterioscler Thromb Vasc Biol, 2007 Nov 21; [Epub ahead of print]. 45860 (2/2008)] Summary Interview

Diabetes Mellitus - vitamin k - 50234

Higher dietary intake of vitamin K1 (phylloquinone) was associated with a reduced incidence of diabetes possibly from vitamin K’s role in reducing insulin resistance, inflammation and, possibly increasing insulin secretion. There are not side effects to increasing dietary vitamin K.

[Am J Clin Nutr. 2012 Nov;96(5):1113-8. 50234 (1/2014)] Interview PubMed

Diabetes Mellitus - whole grain - 39786

Whole grain intake in the top 20% had a 30% reduction in diabetic risk compared to whole grain consumption in the lowest 20% risk at 12 years of followup. [Am J Clin Nutr, 2002;76:535-540. 39786 (2002)] Summary Interview

Diabetes Mellitus - whole grains, cereal fiber - 40342

Whole grains and cereal fiber intake (higher) reduced risk of type 2 diabetes. Highest quartile of whole-grain intake had a 35% lower risk of developing type 2 diabetes compared to the lowest quartile. A 60% lower risk was observed with higher cereal fiber intake. Rye bread was the main type of whole-grain. Fiber derived from fruit or vegetables was not associated with the risk of type 2 diabetes. [Am J Clin Nutr, 2003;77:622-629. 40342 (2003)] Summary Interview

Diabetes Mellitus - zinc - 48733

Zinc - 22 mg of oral elemental zinc from zinc sulfate in a single daily dose (preferably 2 hrs after breakfast) with a multivitamin/mineral supplement. [Diabetes Metab Syndr Obes, 2011 Jan 26;4:53-60. 48733 (8/2011)] Summary Interview PubMed

Diabetic Neuropathy - Diet

Diet - reduces neuropathy with vegan diet which excludes any food or drink that comes from animal, fish, meat, milk or eggs; excludes refined foods such as free fats (oil, shortening or margarine, etc.); free carbohydrates (sugar, syrups, starch, etc.); or refined cereals (white rice, white flour, etc.); or refined legumes (soy protein isolate or soy protein concentrate products). Eat only whole nuts, beans, seeds, whole grains, fruit and vegetables. [J Nutr Medicine, 1994;4:431-439. 21878 (1996)] Summary Interview

Diabetic Neuropathy - Gamma linolenic acid

Gamma linolenic acid (GLA) 480 mg/d. [Diabetes, 1997;46(Suppl. 2):S90-S93. 28204 (1998)] Summary Interview

Diabetic Neuropathy - Protein

Protein (30% soy protein, 35% textured soy protein and 35% animal protein) .8 mg/kg/d. [Diabetes Care, 2008; 31(4): 648-54. 46326 (8/2008)] Summary Interview

Diabetic Neuropathy - Vitamin B1

Vitamin B1 benfothiamine 3 x 100 mg/d for 2 to 3 weeks and thereafter a dose of 1 to 2 x 100 mg/d benefitted diabetic polyneuropathy. [Exp Clin Endocrinol Metab, 1996;104:311-316. 25833 (1997)] Summary Interview

Diabetic Neuropathy - vitamin e - 49891

Vitamin E 400 IU (Evion®; tocopheryl acetate) taken once daily, after meals for 12 weeks in diabetic neuropathy patients showed a significant decrease in the random blood sugar levels; a significant reduction in total pain scores; and a significant improvement in physical health with no side effects and good compliance. [Pharmacol Rep; 66 (1):44-48. 49891 (9/2014) Summary Interview PubMed

Diarrhea - Fruit juice

Fruit juice excess may cause chronic diarrhea in toddlers (one case, filtered apple juice did not cause diarrhea while filtered did). [Acta Pediatrica, 1995; 84:1241-1244. 23680 (1995)] Summary Interview

Diarrhea - Lactobacillus GG

Lactobacillus GG 1 capsule (1010 bacteria) b.i.d. with meals and at the same time as the antibiotic (mixed with food in children) reduced the incidence of antibiotic-associated diarrhea. [J Pediatr 1999;135:564-568. 33808 (2000)] Summary Interview

Diarrhea - Probiotics

Probiotics (multi-strain) at 6 gm per day (200-250 billion bacteria per day) in divided doses away from meals and antibiotics. [Ann Pharmacother. 2007 Jul;41(7):1284-7. Epub 2007 Jun 26. 46026 (12/2007)] Summary Interview

Diarrhea - Zinc

Zinc 20 mg (elemental) from zinc sulfate dissolved in milk or water 2 hours after meals (10 mg/d if under 6 months of age). [J Clin Epidemiol, 2007 Jun;60(6):560-6. Epub 2006 Dec 11. 45975 (10/2007)] Summary Interview

Diet (general) - Crops /Fertilizers

Nutritional content of crops from conventional fertilizers have imbalances in nutritional content and can have excess of toxic metals. [J Altern Complemen Med, 2001;7(2):161-173. 37809 (2001)] Summary Interview

Diet (general) - Crops /Herbicides

Nutritional content of crops from conventional herbicides can have lower protein content. [J Altern Complemen Med, 2001;7(2):161-173. 37809 (2001)] Summary Interview

Diet (general) - fruits and vegetables

Nutritional content of fruits and vegetables has declined over the last 60 years. [J Altern Complemen Med, 2001;7(2):161-173. 37809 (2001)] Summary Interview

Diet (general) - Mediterranean diet

Diet (general) - Mediterranean diet - 2 phenolic/antioxidant compounds; monunsaturated fatty acids replace saturated fat, protect LDL cholesterol from oxidation; moderate dairy product consumption; rich in fruits and vegetables; whole grain bread; reduced in trans fatty acids; low in meat, and dairy products; fruit for dessert except for special occasions. [Am J Clin Nutr, 1995;61(suppl):1402S-6S. 22553 (1996)] Summary Interview

Diet (general) - Mediterranean diet - 2

Mediterranean diet lowers LDL while not effecting HDL cholesterol; olive oil is a monunsaturated fatty acid rich in phenolic/antioxidant compounds; monunsaturated fatty acids replace saturated fat, protect LDL cholesterol from oxidation; moderate dairy product consumption; rich in fruits and vegetables; whole grain bread; reduced in trans fatty acids; low in meat, and dairy products; fruit for dessert except for special occasions. [Am J Clin Nutr, 1995; 61(Suppl.):1321S-3S. 22547 (1995)] Summary Interview

Diet (general) - Organic crops

Organic crops had on average up to 30% more vitamin C, iron, magnesium and phosphorus and significantly less nitrates. [J Altern Complemen Med, 2001;7(2):161-173. 37809 (2001)] Summary Interview

Diet (general) - Organic farming

Organic farming benefits include cleaner water; an absence of pesticide residues; preserves wildlife habitat and wildlife is not poisoned; organic composts can breakdown pesticides and other toxic chemicals thereby cleaning the environment; and safeguarding and replenishing topsoil. [J Altern Complemen Med, 2001;7(2):161-173. 37809 (2001)] Summary Interview

Diet (general) - Organic grown protein

Organic grown protein is of lower quantity but better quality for human nutrition due to the reduction in nitrogen use. [J Altern Complemen Med, 2001;7(2):161-173. 37809 (2001)] Summary Interview

Diet (general) - Pediatric nutrition

Pediatric nutrition - average child in U.S. views more than 25 hours of television per week; approximately 3 hrs/wk of food advertisements; 43.6% in "fats, oils and sweets" food group, 37.5% in "bread, cereal, rice and pasta group (23% of these were for high-sugar breakfast cereals); 11% for fast-food restaurants. [J Am Diet Assoc, April 14, 1994;94:1296-1300. 21597 (1995)] Summary Interview

Diet (general) - Pediatric nutrition - 2

Pediatric nutrition - children watch on television 21.3 commercials per hour; 47.6% were food related; 91% of commercials were high in fat, salt or sugar; children 3 to 5 years of age watch on average 21.4 hours per week; #1 category of advertised foods were cereals, #2 were candies and other snack foods;15% of food-related commercials were for restaurants - mostly fast-food; of cereals advertised 85% were high in sugar; of the advertised beverages, a minority were carbonated (5.6%); 83.2% were beverages that were sweetened. [Arch Pediatr Adolescent Med, June, 1995;149:649-652. 22563 (1996)] Summary Interview

Diet (general) - Pediatric nutrition - 3

Pediatric nutrition - half of all the television ads that children view are for food, especially sugar–rich cereal and high-caloric snacks; on Saturday morning television 61% of the commercials are for food, and more than 90% of those are for sugared-cereals, candy bars, fast-foods, chips, and other nutritionally unsound foods; one-quarter of all preschoolers, one-half of all older children, and two-thirds of all teenagers have a television set in their own bedroom. [Develop Behav Pediatr, June 2001;22(3):185-187. 38178 (2001)] Summary Interview

Diet (general) - Primate diet vs. Western diet

Nutritional content of versus Western diet - more leafy vegetables, wild fruit, fiber, alpha-linolenic acid, vitamin C, plant protein, less high calorie-carbohydrate/sugar rich food. [Nutrition 1999;15(6):488-498. 33148 (2000)] Summary Interview

Diet (general) - Vegan

Vegan diets, and to a lesser extent lacto-ovovegetarian diets, have reduced toxin and heavy metal exposure than animal food-based diets. [Am J Clin Nutr, 2004;80:237-238. 41817 (2004)] Summary Interview

Docosahexaenoic Acid - Functions

Functions - anti-inflammatory by converting to EPA; converts moderately to EPA; flaxseed oils ALA can convert somewhat to DHA; heart attack mortality reduced; plant source from microalgae; memory function; neurodevelopement of fetus/infant; triglyceride lowering. [Pharmacol Res 1999;49(3):211-225. 33885 (2000)] Summary Interview

Down Syndrome - Folate metabolism

Folate metabolism disorder in mother. [Eur J Obstet Gynecol Reprod Biol, 2006 Feb 1;124(2):130-3. Epub 2005 Oct 5. 44196/44621 (4/2006)] http://www.vitasearch.com/get-clp-summary/35220 Summary

Down Syndrome - Folic acid /B12

Folic acid and/or B12 supplementation to normalize altered “One Carbon Metabolism “ important for methylation; DNA/RNA nucleotide synthesis. [Eur J Obstet Gynecol Reprod Biol, 2006 Feb 1;124(2):130-3. Epub 2005 Oct 5. 44196/44621 (4/2006)] Summary Interview

Dry Eye Syndrome - antioxidants, dhe, epa - 505455

Brudysec® 1.5 grams (Brudy Laboratories, Barcelona, Spain) containing DHA (350 mg) / EPA (42.5 mg) combined with antioxidants (vitamins A, C and E, tyrosine, cysteine, glutathione, zinc, copper, manganese and selenium) in each capsule taken with each meal (3 capsules total daily). [ Clin Ophthalmol. 2014;8: 831–836. 50545 (11/2016)] Interview PubMed

Dry Eye Syndrome - omega-3 fatty acids - 49814

Omega 3 fatty acids 1 capsule (325 mg and DHA 175 mg) twice daily significantly improved tear film stability and symptom improvement, with only a slight, nonsignificant increase in average tear production. Side effects were some skin rashes and GI discomfort, but not enough for anyone to discontinue the therapy. [Int J Opthalmol, 2013 Dec 18;6(6):811-6. 49814 (3/2014)] Summary Interview PubMed

Dry Eye Syndrome - sea buckthorn oil - 48071

Sea buckthorn oil in 500 mg capsules at 2 grams per day in divided doses with meals. [J Nutr, June 16, 2010; [Epub ahead of print]. 48071 (8/2010)] Summary Interview PubMed

Dysfunctional Gut Syndrome - Diet

Diet low in fermentable, starchy and yeasty foods; diet high in unrefined starches and vegetables - small amounts of fruit; higher in fats and protein; supplement with B vitamins, magnesium, gamma-linolenic acid; reduce or eliminate the consumption of refined sugars and a high intake of lectins. [J Royal Soc Med, 1995;88:63-66. 22682 (1995)] Summary Interview

Dysfunctional Gut Syndrome - Gut fermentation

Abnormal gut fermentation frequently presents with symptoms of irritable bowel, catarrhal symptoms and mild cerebral dysfunction such as inability to concentrate, fatigue and "brain fog or fag.” The best test is excess ethanol production on a fasting sugar challenge (normal < 22 micromoles per liter). Excess β-alanine excretion is another test. [J Royal Soc Med, 1995;88:63-66. 22682 (1995)] Summary Interview

Dyslexia - Fatty acid

Fatty acid (PUFA) - high-DHA (docosahexaenoic acid) fish oil and evening primrose oil (daily dose: 480 mg DHA, 108 mg EPA, 96 mg GLA, and 35 mg AA) given in two divided doses with meals. [J Med Food, 2007;10(4): 662-6. 46027 (5/2008)] Summary Interview

Dysmenorrhea - calcium, vitamin d - 49819

Lower levels of dietary calcium (< 1 serving per day of dairy foods per day) and vitamin D insufficiency (vitamin D 10-19 ng/ml) were associated with severe and very severe dysmenorrhea. In one study 3 servings of dairy foods per day and more direct sunlight, or vitamin D normalization through supplementation, reduced dysmenorrhea significantly. [J Pediatr Adolesc Gyneco, 2014 Jan 6; [Epub ahead of print]. 49819 (3/2014)] Summary Interview PubMed

Dysmenorrhea - Eicosapentaenoic acid

Eicosapentaenoic acid (EPA) 1 gm and docosapentaenoic acid (DPA) 0.72 gm per day in 2 divided doses. [Am J Obstet Gynecol, April, 1996;174: 1335-8. 24741 (1996)] Summary Interview

Dysmenorrhea - Pycnogenol®

Pycnogenol® 30 mg b.i.d. after morning and evening meals. [J Reprod Med, 2008; 53(5): 338-46. 46418 (8/2008)] Summary Interview

Dyspepsia - Artichoke leaf extract

Artichoke leaf extract (ALE) 320 mg 6/d (1920 mg of total standardized extract). [J Altern Complem Med, 2004;10(4):667-669. 42219 (12/2004)] Summary Interview

Dysplasia (cervical) - Antioxidants

Antioxidants in the diet reduced. [Am J Repro Immunol, 1994;32:221-225. 21510 (1996)] Summary Interview

Ear infection - Elimination diet

Food elimination diet of cows milk, wheat, egg white, peanut, soy, orange, tomato, chicken and apple. [Ann Allergy, September 1994;73:215-219. 20995 (1996)] Summary Interview

Ear Infection - Food allergy

Food allergy a cause of. [Ann Allergy, September 1994;73:215-219. 20995 (1996)] Summary Interview

Encephalopathy - Acetyl-L-carnitine

Acetyl-L-carnitine (ALC) 2gm b.i.d..(hepatic encephalopathy] [Dig Dis Sci, 2008 Mar 21; [Epub ahead of print]. 46359 (06-15-08)] ltt Summary

Encephalopathy - Antioxidant

Antioxidant mixture by mouth including CoQ10, NADH, vitamin E, alpha-lipoic acid, a multivitamin in a fresh fruit and vegetable puree (in hospital by family, case report); subsequent gastric feeding tube administration (rehabilitation hospital) of CoQ10, alpha-lipoic acid, NADH, vitamin C, vitamin E, B complex, multivitamin-mineral mixture, L-glutamine, omega 3 fatty acids, magnesium and a pureed mixture of fruits and vegetables concurrent with parenteral glutathione and ascorbate. (spongiform encephalitis/Creutzfeldt-Jakob disease). [J Am Coll Nutr, 2002;21(1):22-25. 38833 (2002)] Summary Interview

Encephalopathy - Coenzyme Q10

Coenzyme Q10 30 mg/kg/day in three divided doses (pediatric, genetic defect, coenzyme Q10 deficiency). [Neurology, 2005 Aug 23;65(4):606-8. 43616/43808 (11/2005)] Summary Interview

Endothelial Function - alpha lipoic acid - 50564

Alpha lipoic acid (ALA) at 1800 mg per day in obese subjects with hypertension, diabetes mellitus, or hypercholesterolemia lead to modest weight loss. [Curr Med Chem. 2014 Jul 6. [Epub ahead of print] 50564 (11/2104)] Interview PubMed

Endothelial Function - arginine - 32138

Arginine (L-) 5-8 gm/d is minimum effective dose; 18-20 gm/d is a maximum effective dose without significant side effects. [Cardiology 1999;90:153-159. 32138 (1999)] Summary Interview

Endothelial Function - calcium - 36718 / 39257

Calcium 1000 mg/d plus 2 mg estriol increased BMD and improved endothelial function. [J Am Geriatri Soc, April 2002;50(4):777-778. 36718 / 39257 (2002)] Summary

Endothelial Function - citrulline - 48344

L-citrulline with water at 2.4 grams in the morning before breakfast and 3.2 grams in the evening before sleeping. [Int J Cardiol, 2010, Nov 8; [Epub ahead of print]. 48344 (1/2011)] Summary Interview PubMed

Endothelial Function - coenzyme q10 - 45545

Coenzyme Q10 100 mg t.i.d. with meals improved endothelial function and extracellular SOD. [Eur Heart J, 2007 Jul 19; [Epub ahead of print]. 45545 (9/2007)] Summary Interview

Endothelial Function - curcumin - 49419

Curcumin (Theracurumin®; Theravalues Corp, Japan), at 150 mg per day divided into 6 capsules (1 capsule contained 25 mg curcumin), 3 capsules after breakfast and 3 after dinner, improved endothelial function. [Nutr Res, 2012 Oct; 32(10): 795-9. 49419 (12/2012)] Summary Interview PubMed

Endothelial Function - diet - 28669

Diet - high fat meal increases endothelial dysfunction. [JAMA, November 26, 1997;278(20):1682-1686. 28669 (1998)] Summary Interview

Endothelial Function - diet / trans fatty acids - 42103

Diet rich in trans fatty acids (margarine, commercially baked products, and deep-fried fast food) impairs endothelial function. [Am J Clin Nutr, 2004;80:1029-1035. 42103 (11/2004)] Summary Interview

Endothelial Function - folic acid - 22602 / 22112

Folic acid 5 mg/d and vitamin B6 250 mg/d. [Eur J Clin Investigation, 1995;25:176-181. 22602/22112 (1996)] Summary Interview

Endothelial Function - garlic - 49298

Garlic - aged garlic extract compound (Kyolic Formula 109) delivering1200 mg of AGE and 120 mg of CoQ10 (4 tablets per day). [Nutrition, 2012 Aug 1; [Epub ahead of print]. 49298 (8/2012)] Summary Interview PubMed

Endothelial Function - green tea catechins - 47757

Green tea catechins 80 to 580 mg/day once daily with meals. [Circ J, 2010 Feb 4; [Epub ahead of print]. 47757 (3/2010)] Summary Interview PubMed

Endothelial Function - isoflavone - 46714

Isoflavone 80 mg/day in a single dose with or without food. [Eur Heart J, 2008 Sept 23; [Epub ahead of print]. 46714 (12/2008) Summary

Endothelial Function - magnesium - 48178

Magnesium pidolate, a bioavailable organic salt, given by mouth at a dose of 4.5 grams per day providing 368 milligrams of elemental magnesium in two divided doses (morning and evening), with or without meals improve endothelial function. [Magnes Res, 2010 Aug 24; [Epub ahead of print]. 48178 (10/2010)] Summary Interview PubMed

Endothelial Function - omega-3 fatty acids - 46407

Omega-3 fatty acids (2 g/d DHA and 3 g/d EPA, fish oil) in 3 divided doses with meals increased stroke volume and cardiac output. [Eur J Appl Physiol, 2008 June 18; [Epub ahead of print]. 46407 (8/2008)] Summary Interview

Endothelial Function - tea (black) - 45109

Tea (black) - the addition of milk negates the enhancement of nitric oxide and improvement in endothelial function that plain tea provides by milk caseins forming complexes with the protective tea catechins. [Eur Heart J, 2007; 28(2): 219-23. 45109 (6/2007)] Summary Interview

Endothelial Function - vitamin c - 28669

Vitamin C 1,000 mg/d and vitamin 800 IU/d after high fat meal. [JAMA, November 26, 1997;278(20):1682-1686. 28669 (1998)] Summary Interview

Endothelial Function - vitamin c - 29230 / 29224

Vitamin C 2 gm/d in heart failure patients. [Circulation, 1998;97:363-368. 29230/29224 (1998)] Summary Interview

Endothelial Function - vitamin c - 33832

Vitamin C .5-2gm/d. [Eur Heart J, 1999;1676-1680. 33832 (2000)] Summary Interview

Endothelial Function - vitamin c - 33832

Vitamin C 3 gm in an intravenous infusion of 100 ml 0.9% saline over 10 minutes. [Eur Heart J 1999;1676-1680. 33832 (2000)] Summary Interview

Endothelial Function - vitamins c - 40905

Vitamins C 500 mg/d and E 400 IU/d. [Circulation, 2003;108:1059-1063. 40905 (2003)] Summary Interview

Endothelial FunctionDiet - fruits / vegetables / fish - 42103

Diet rich in fruits (antioxidants), vegetables (folic acid), and fish (n-3 fatty acid) benefits endothelial function. [Am J Clin Nutr, 2004;80:1029-1035. 42103 (11/2004)] Summary Interview

Enteritis (radiation-induced) - Lactobacillus acidophilus

Lactobacillus acidophilus (NFCO) 1748 daily 1010 c.f.u. daily in 150 ml of yogurt starting 5 days prior to radiotherapy, daily during the therapy and for 10 days after completing radiotherapy. [Fifth International Meeting on Progress on Radio-Oncology, May 1995;10-14:501-504. 23402 (1995)] Summary Interview

Enuresis (nocturnal) - Acupuncture therapy

Acupuncture therapy (traditional Chinese). [Scand J Urol Nephrol, 2001;35:40-43. 37046 (2001)] Summary Interview

Epilepsy (see seizures) - Eicosapentaenoic Acid

Eicosapentaenoic Acid (EPA) 1 gm/d and docosahexaenoic acid (DHA) .7 gm/d (refractory seizures). [Epilepsy Behav. 2005 Sep;7(2):253-8. 43785 /44072 (1/2006)] Summary Interview

Epilepsy (see seizures) - Multivitamin /Mineral

Multivitamin/mineral, calcium, magnesium, selenium (glutathione peroxidase), zinc, folic acid, vitamins B6, B12, C, D, E and K. [J Pharmacol Sci 2005 Aug;98(4):340-53. Epub 2005 Aug 2. 44610 (5/2006)] Summary Interview

Epitaxis - n-acetylcysteine - 47360

N-acetylcysteine 600 mg t.i.d. with or without meals in patient with Hereditary Hemorrhagic Telangiectasias. [Rhinology, 2009 Mar;47(1):85-8. 47360 (12/2009)] Summary Interview PubMed

Erectile Dysfunction - acetyl-L-carnitine - 43770

Acetyl-L-carnitine 2 gm/d and proprionyl-l-carnitine 2 gms/d. [Urology, 2005;66(5):1080-5. 43770 (5/2006)] Summary Interview

Erectile Dysfunction - arginine - 44952

Arginine 1.7 g/d (dipeptide arginyl aspartate) and Pycnogenol® 80-120 mg/d. [Sex Marital Ther. 2003 May-Jun;29(3):207-13. 44952 (7/2006)] Summary Interview

Erectile Dysfunction - cardiovascular disease, nitric oxide - 50099

Exercise 30 minutes of moderate to vigorous intensity daily; 500-1,000 mg of EPA/DHA daily; increased intake of antioxidants (i.e. green tea, dark chocolate, berries, fruits and vegetables, red wine); 500-1,000 mg of vitamin C, and/or 2 capsules of pycnogenol (usual capsules contain 40-60 mg per capsule); folic acid (400 ug per day); avoid excessive alcohol, and decrease fat and sugar intakes; along with pelvic floor exercise can achieve results equal to or better than the phosphodiesterase 5 inhibitors (Cialis, Levitra and Viagra). L-arginine at 5 gms/d has improved ED in some studies. 2-3 gm of L-citrulline will most likely have a similar effect since it is the intracellular source of arginine and about half of the arginine dose is required for similar blood levels. Vegetables are a natural source of nitric oxide. Dr. Meldrum's book about ED (with Joseph C. Gambone, DO, MPH , Marge Morris, M Ed, RD, CDE and Claudia Meldrum) is "Survival of the Firmest" and website http://www.erectile-function.com/. Am J Cardiol, 2011 Aug 15;108(4):599-606. Epub 2011 May 31. 50099 (5/2012)] Interview PubMed

Erectile Dysfunction - diet, lifestyle - 50637

Erectile function can be enhanced significantly by diet, supplements and lifestyle factors that increase nitric oxide which increase blood flow into the penis by relaxing and dilating the penile artery, and, by the strengthening of pelvic floor muscles with pelvic floor exercises (PFE) which keep the blood trapped in the penis longer to maintain an erection. Beneficial lifestyle factors include; weight control, exercise, reduced intake of fat and sugar, increased intake of fruits and vegetables, moderate alcohol, and limiting barbequing and grilling/broiling of foods. Supplements that can help increase nitric oxide include folic acid, omega-3 fatty acids (fish oil) and pycnogenol. Instructions on PFE and Dr. Meldrum’s book, “Survival of the Firmest” are available at www.erectile-function.com. [J Sex Med. 2014 May;11(5):1208-20. 50637 (1/2015)] Interview PubMed

Erectile Dysfunction - korean red ginseng - 45682

Korean Red Ginseng 1000 - 3000 mg/d before breakfast. [Asian J Androl, 2007; 9(2): 241-4. 45682 (11/2007)] Summary

Erectile Dysfunction - periodontal disease - 50171

Vasculogenic erectile dysfunction (VED) can be affected by chronic periodontitis do to inflammatory cytokines released that can negatively affect endothelial dysfunction of the small vessels in the penis. Diets that are rich in protein, whole grains, fiber, vitamins, minerals and PUFAs have positive effects on periodontal health and can improve endothelial function and reduce vulnerability to VED. [J Periodonto, 2011 Dec;82(12):1665-9. 50171 (4/2013)] Interview PubMed

Erectile Dysfunction - propionyl-l-carnitine - 45315

Carnitine - propionyl-l-carnitine (PLC) 1 gm b.i.d. independently from Sildenafil 50 mg b.i.w. and meals in diabetic patients with erectile dysfunction reduced oxidative stress and improved endothelial dysfunction markers in type 2 diabetic patients with erectile dysfunction and had more sustained improvement in symptoms of E.D. than Sildenafil alone. [Eur Urol, 2007 Apr 25; [Epub ahead of print]. 45315 (7/2007)] Summary Interview

Erectile Dysfunction - sunlight, vitamin d -

Vitamin D 6000 IU/d with 25 hydroxy vitamin D3 levels between 60-80 ng/ml. [Dermatoendocrinol. 2012 Apr 1;4(2):128-36. 50259 (1/2014)] Interview PubMed

Erectile Dysfunction - yohimbine - 26601 / 26602

Erectile DysfunctionYohimbine 5-10 mg t.i.d.. [Arch Sexual Behavior, 1997;26(1):49-62. 26601 / 26602 (1997)] Summary Interview

Erectile Dysfunction - yohimbine - 39233

Yohimbine 5.4 mg -10.8 mg t.i.d. or 5.4 mg 1-2 tablets 15-30 minutes before sex. [Intern J Impotence Res,2002;14:25-31. 39233 (2002)] Summary Interview

Erythema Nodosum - Vitamin B12

Vitamin B12 I.M. 1000 mcg twice a week x 4 weeks then monthly I.M. vitamin B12 1000 mcg. At six months oral sublingual vitamin B12 1000 mcg twice a week (case report of complete remission). [J Am Board Fam Pract. 2005 Nov-Dec;18(6):567-9. 43946/44357 (1/2006)] Summary Interview

Erythroderma - Folic acid

Folic acid 2.5 mg/d, vitamins B6 50 mg/d and vitamin B12 1 mg/d (in case of concurrent methotrexate therapy supplementation with 15 mg of calcium folinate the day after the administration of methotrexate). [ J Dermatolog Treat, 2007;18(3):138-46. 44991/45996 (11/2007)] Summary Interview

Estrogen Metabolism - Dioxin exposure

Dioxin exposure may decrease the 2:16 estrogen ratio by increasing16-hydroxyestrogens. [Arch Environ Occup Health, 2005 Jul-Aug;60(4):215-22. 45639 (03/2007)] Summary Interview

Exercise - antioxidants - 24460

Antioxidants (beta-carotene, vitamin C, vitamin E) can reduce oxidative damage in heavy exercisers. [Sports Medicine, 1996;21(3):213-238. 24460 (1996)] Summary Interview PubMed

Exercise - antioxidants - 34758

Antioxidants - beta-carotene 32 mg/d, vitamin C 1000 mg/d, vitamin E 600 mg/d reduced lipid peroxides and prevented reductions in vitamin C levels in professional basketball players. [Int J Sports Med, 2000;21(2):146-150 . 34758 (2000)] Summary Interview PubMed

Exercise - athletes, probiotics - 48851

Lactobacillus rhamnosus and Lactobacillus paracase at 109 cells per day in a powder suspended in water (aqueous suspension) in the morning, during breakfast in a single dose. [ Curr Microbiol, 2011 June; 62(6):1689-96. 48851 (11/2011)] Summary Interview PubMed

Exercise - beetroot juice - 47417

Beetroot juice (nitrate rich) 500 ml sipped throughout the day. [J Appl Physiol, August 6, 2009; [Epub ahead of print]. 47417 (10/2009)] Summary Interview PubMed

Exercise - beetroot juice - 49617

Beetroot juice at 140 ml (~8 mmol of nitrate) taken 2.5 hours before exercise.

[J Appl Physiol, 2013 May 2; [Epub ahead of print]. 49617 (6/2013)] Summary Interview PubMed

Exercise - beets - nitric oxide - 50122

Beetroot - 200 grams of baked, peeled and chopped beetroot (≥500 mg nitrate), mixed with cinnamon and other herbs for palatability, taken on an empty stomach 45-60 minutes before running. [JAcad Nutr Diet, 2012 Apr;112(4):548-52. 50122 (9/2012)] Interview PubMed

Exercise - branch chain amino acids (bcca) - 45547

Branch chain amino acids (BCAA) 6 gms/d in 5 divided doses during the run, an additional 2 grams administrated on the day of 25-km run (2g/500ml; 0.4% mixture of BCAA in a 4% carbohydrate solution) reduced muscle soreness, fatigue and LDH elevation. [J Sports Med Phys Fitness, 2007; 47(3): 316-322. 45547 (12/2007)] Summary Interview PubMed
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